|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 19 3827-3834, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
Z Paroush, SM Wainwright and D Ish-Horowicz
Imperial Cancer Research Fund, London, UK. zparoush@cc.huji.ac.il
Patterning of the non-segmental termini of the Drosophila embryo depends on signalling via the Torso receptor tyrosine kinase (RTK). Activation of Torso at the poles of the embryo triggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb). In this paper, we show that the Groucho (Gro) corepressor acts in this process to confine terminal gap gene expression to the embryonic termini. Embryos lacking maternal gro activity display ectopic tll and hkb transcription; the former leads, in turn, to lack of abdominal expression of the Kruppel and knirps gap genes. We show that torso signalling permits terminal gap gene expression by antagonising Gro-mediated repression. Thus, the corepressor Gro is employed in diverse developmental contexts and, probably, by a variety of DNA-binding repressors.
This article has been cited by other articles:
|
|
 |
|
  Y.-C. Chen, S. I. Lin, Y.-K. Chen, C.-S. Chiang, and G.-J. Liaw The Torso signaling pathway modulates a dual transcriptional switch to regulate tailless expression Nucleic Acids Res., January 7, 2009; (2009) gkn1036v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cinnamon, A. Helman, R. Ben-Haroush Schyr, A. Orian, G. Jimenez, and Z. Paroush Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis Development, March 1, 2008; 135(5): 829 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Moran and G. Jimenez The tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryo. Mol. Cell. Biol., May 1, 2006; 26(9): 3446 - 3454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Song, P. Hasson, Z. Paroush, and A. J. Courey Groucho Oligomerization Is Required for Repression In Vivo Mol. Cell. Biol., May 15, 2004; 24(10): 4341 - 4350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. X. Li, H. Agaisse, B. Mathey-Prevot, and N. Perrimon Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila Development, March 11, 2003; 129(18): 4241 - 4248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Green, V. Hatini, K. A. Johansen, X.-J. Liu, and J. A. Lengyel Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the Drosophila hindgut Development, August 1, 2002; 129(15): 3645 - 3656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Barolo and J. W. Posakony Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling Genes & Dev., May 15, 2002; 16(10): 1167 - 1181. [Full Text] [PDF]
|
|
|
|
|
|
L. P. M. Andrioli, V. Vasisht, E. Theodosopoulou, A. Oberstein, and S. Small Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms Development, January 11, 2002; 129(21): 4931 - 4940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Goff, L. A. Nilson, and D. Morisato Establishment of dorsal-ventral polarity of the Drosophila egg requires capicua action in ovarian follicle cells Development, November 15, 2001; 128(22): 4553 - 4562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Courey and S. Jia Transcriptional repression: the long and the short of it Genes & Dev., November 1, 2001; 15(21): 2786 - 2796. [Full Text] [PDF]
|
|
|
|
|
|
F. Janody, R. Sturny, V. Schaeffer, Y. Azou, and N. Dostatni Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway Development, June 15, 2001; 128(12): 2281 - 2290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Kobayashi, R. Goldstein, M Fujioka, Z Paroush, and J. Jaynes Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries Development, January 5, 2001; 128(10): 1805 - 1815. [Abstract] [PDF]
|
|
|
|
|
|
G. Jiménez, A. Guichet, A. Ephrussi, and J. Casanova Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning Genes & Dev., January 15, 2000; 14(2): 224 - 231. [Abstract] [Full Text]
|
|
|
|
|
|
V Schaeffer, D Killian, C Desplan, and E. Wimmer High bicoid levels render the terminal system dispensable for Drosophila head development Development, January 9, 2000; 127(18): 3993 - 3999. [Abstract] [PDF]
|
|
|
|
|
|
F Janody, J Reischl, and N Dostatni Persistence of Hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development Development, January 4, 2000; 127(8): 1573 - 1582. [Abstract] [PDF]
|
|
|
|
|
|
F Janody, R Sturny, F Catala, C Desplan, and N Dostatni Phosphorylation of bicoid on MAP-kinase sites: contribution to its interaction with the torso pathway Development, January 1, 2000; 127(2): 279 - 289. [Abstract] [PDF]
|
|
|
|
|
|
G. Chen, J. Fernandez, S. Mische, and A. J. Courey A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development Genes & Dev., September 1, 1999; 13(17): 2218 - 2230. [Abstract] [Full Text]
|
|
|
|
|
|
R. Goldstein, G Jimenez, O Cook, D Gur, and Z Paroush Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho Development, January 9, 1999; 126(17): 3747 - 3755. [Abstract] [PDF]
|
|
|
|
|
|
A Reich, A Sapir, and B Shilo Sprouty is a general inhibitor of receptor tyrosine kinase signaling Development, January 9, 1999; 126(18): 4139 - 4147. [Abstract] [PDF]
|
|
|
|
|
|
A. L. Fisher and M. Caudy Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates Genes & Dev., July 1, 1998; 12(13): 1931 - 1940. [Full Text]
|
|
|
|
|
|
T. Dubnicoff, S. A. Valentine, G. Chen, T. Shi, J. A. Lengyel, Z.'e. Paroush, and A. J. Courey Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho Genes & Dev., November 15, 1997; 11(22): 2952 - 2957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jimenez, Z.'e. Paroush, and D. Ish-Horowicz Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed Genes & Dev., November 15, 1997; 11(22): 3072 - 3082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Wang, M. Waltner-Law, K. Yamada, H. Osawa, S. Stifani, and D. K. Granner Transducin-like Enhancer of Split Proteins, the Human Homologs of Drosophila Groucho, Interact with Hepatic Nuclear Factor 3beta J. Biol. Chem., June 9, 2000; 275(24): 18418 - 18423. [Abstract] [Full Text] [PDF]
|
|
