|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 21 4321-4331, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
G Begemann, N Paricio, R Artero, I Kiss, M Perez-Alonso and M Mlodzik
Developmental Biology Programme, EMBL, Heidelberg, Germany.
We have isolated the embryonic lethal gene muscleblind (mbl) as a suppressor of the sev-svp2 eye phenotype. Analysis of clones mutant for mbl during eye development shows that it is autonomously required for photoreceptor differentiation. Mutant cells are recruited into developing ommatidia and initiate neural differentiation, but they fail to properly differentiate as photoreceptors. Molecular analysis reveals that the mbl locus is large and complex, giving rise to multiple different proteins with common 5' sequences but different carboxy termini. Mbl proteins are nuclear and share a Cys3His zinc-finger motif which is also found in the TIS11/NUP475/TTP family of proteins and is highly conserved in vertebrates and invertebrates. Functional analysis of mbl, the observation that it also dominantly suppresses the sE-Jun(Asp) gain-of-function phenotype and the phenotypic similarity to mutants in the photoreceptor-specific glass gene suggest that mbl is a general factor required for photoreceptor differentiation.
This article has been cited by other articles:
|
|
 |
|
  S.-i. Hino, S. Kondo, H. Sekiya, A. Saito, S. Kanemoto, T. Murakami, K. Chihara, Y. Aoki, M. Nakamori, M. P. Takahashi, et al. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1 Hum. Mol. Genet., December 1, 2007; 16(23): 2834 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Warf and J. A. Berglund MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T RNA, December 1, 2007; 13(12): 2238 - 2251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Tenlen, J. A. Schisa, S. J. Diede, and B. D. Page Reduced Dosage of pos-1 Suppresses Mex Mutants and Reveals Complex Interactions Among CCCH Zinc-Finger Proteins During Caenorhabditis elegans Embryogenesis Genetics, December 1, 2006; 174(4): 1933 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Osborne and C. A. Thornton RNA-dominant diseases Hum. Mol. Genet., October 15, 2006; 15(suppl_2): R162 - R169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de Haro, I. Al-Ramahi, B. De Gouyon, L. Ukani, A. Rosa, N. A. Faustino, T. Ashizawa, T. A. Cooper, and J. Botas MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1 Hum. Mol. Genet., July 1, 2006; 15(13): 2138 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Houseley, Z. Garcia-Casado, M. Pascual, N. Paricio, K. M. C. O'Dell, D. G. Monckton, and R. D. Artero Noncanonical RNAs From Transcripts of the Drosophila muscleblind Gene J. Hered., May 1, 2006; 97(3): 253 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Monferrer and R. Artero An Interspecific Functional Complementation Test in Drosophila for Introductory Genetics Laboratory Courses J. Hered., January 1, 2006; 97(1): 67 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Houseley, Z. Wang, G. J. R. Brock, J. Soloway, R. Artero, M. Perez-Alonso, K. M. C. O'Dell, and D. G. Monckton Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila Hum. Mol. Genet., March 15, 2005; 14(6): 873 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Romero, M. Plonczynski, G. R. Vergara, E. P. Gomez-Sanchez, and C. E. Gomez-Sanchez Angiotensin II early regulated genes in H295R human adrenocortical cells Physiol Genomics, September 16, 2004; 19(1): 106 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kino, D. Mori, Y. Oma, Y. Takeshita, N. Sasagawa, and S. Ishiura Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats Hum. Mol. Genet., March 1, 2004; 13(5): 495 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Kanadia, K. A. Johnstone, A. Mankodi, C. Lungu, C. A. Thornton, D. Esson, A. M. Timmers, W. W. Hauswirth, and M. S. Swanson A Muscleblind Knockout Model for Myotonic Dystrophy Science, December 12, 2003; 302(5652): 1978 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Faustino and T. A. Cooper Pre-mRNA splicing and human disease Genes & Dev., February 15, 2003; 17(4): 419 - 437. [Full Text] [PDF]
|
|
|
|
|
|
M. Fardaei, M. T. Rogers, H. M. Thorpe, K. Larkin, M. G. Hamshere, P. S. Harper, and J. D. Brook Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells Hum. Mol. Genet., April 1, 2002; 11(7): 805 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fardaei, K. Larkin, J. D. Brook, and M. G. Hamshere In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts Nucleic Acids Res., July 1, 2001; 29(13): 2766 - 2771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Prokopenko, Y. He, Y. Lu, and H. J. Bellen Mutations Affecting the Development of the Peripheral Nervous System in Drosophila: A Molecular Screen for Novel Proteins Genetics, December 1, 2000; 156(4): 1691 - 1715. [Abstract] [Full Text]
|
|
