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Development, Vol 124, Issue 22 4697-4705, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
M Strigini and SM Cohen
European Molecular Biology Laboratory, Heidelberg, Germany.
The secreted protein Hedgehog (Hh) transmits a signal from posterior to anterior cells that is essential for limb development in insects and vertebrates. In Drosophila, Hh has been thought to act primarily to induce localized expression of Decapentaplegic and Wingless which in turn relay patterning cues at long range. We report here that Hh plays an additional role in patterning the wing. By replacing endogenous Hh activity with that of a membrane-tethered form of Hh, we show that Hh acts directly to pattern the central region of the wing, in addition to its role as an inducer of Dpp. Comparing the biological activities of secreted and membrane-tethered Hh provides evidence that Hh forms a local concentration gradient and functions as a concentration-dependent morphogen in the fly wing.
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K Weigmann and S. Cohen Lineage-tracing cells born in different domains along the PD axis of the developing Drosophila leg Development, January 9, 1999; 126(17): 3823 - 3830. [Abstract] [PDF]
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P. Therond, B Limbourg Bouchon, A Gallet, F Dussilol, T Pietri, M van den Heuvel, and H Tricoire Differential requirements of the fused kinase for hedgehog signalling in the Drosophila embryo Development, January 9, 1999; 126(18): 4039 - 4051. [Abstract] [PDF]
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M. Milán, F. J. Diaz-Benjumea, and S. M. Cohen Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function Genes & Dev., September 15, 1998; 12(18): 2912 - 2920. [Abstract] [Full Text]
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B Biehs, M. Sturtevant, and E Bier Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs Development, January 11, 1998; 125(21): 4245 - 4257. [Abstract] [PDF]
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Z. Chamoun, R. K. Mann, D. Nellen, D. P. von Kessler, M. Bellotto, P. A. Beachy, and K. Basler Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal Science, September 14, 2001; 293(5537): 2080 - 2084. [Abstract] [Full Text] [PDF]
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J. P. Incardona, J. H. Lee, C. P. Robertson, K. Enga, R. P. Kapur, and H. Roelink Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1 PNAS, October 24, 2000; 97(22): 12044 - 12049. [Abstract] [Full Text] [PDF]
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