Development, Vol 124, Issue 24 5087-5096, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6

D Caric, D Gooday, RE Hill, SK McConnell and DJ Price
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.

The cerebral cortex forms by the orderly migration and subsequent differentiation of neuronal precursors generated in the proliferative ventricular zone. We studied the role of the transcription factor Pax-6, which is expressed in the ventricular zone, in cortical development. Embryos homozygous for a mutation of Pax-6 (Small eye; Sey) had abnormalities suggesting defective migration of late-born cortical precursors. When late-born Sey/Sey precursors were transplanted into wild-type embryonic rat cortex, they showed similar integrative, migrational and differentiative abilities to those of transplanted wild-type mouse precursors. These results suggest that postmitotic cortical cells do not need Pax-6 to acquire the capacity to migrate and differentiate, but that Pax-6 generates a cortical environment that permits later-born precursors to express their full developmental potential.

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