|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 6 1109-1117, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
D Macias, Y Ganan, TK Sampath, ME Piedra, MA Ros and JM Hurle
Departamento de Ciencias Morfologicas, Universidad de Extremadura, Badajoz, Spain.
Bone Morphogenetic Protein 2 (BMP-2) and Osteogenic Protein 1 (OP-1, also termed BMP-7) are members of the transforming growth factor beta superfamily. In the present study, we have analyzed the effects of administering them locally at different stages and locations of the chick limb bud using heparin beads as carriers. Our results show that these BMPs are potent apoptotic signals for the undifferentiated limb mesoderm but not for the ectoderm or the differentiating chondrogenic cells. In addition, they promote intense radial growth of the differentiating cartilages and disturb the formation of joints accompanied by alterations in the pattern of Indian hedgehog and ck-erg expression. Interestingly, the effects of these two BMPs on joint formation were found to be different. While the predominant effect of BMP-2 is alteration in joint shape, OP-1 is a potent inhibitory factor for joint formation. In situ hybridizations to check whether this finding was indicative of specific roles for these BMPs in the formation of joints revealed a distinct and complementary pattern of expression of these genes during the formation of the skeleton of the digits. While Op-1 exhibited an intense expression in the perichondrium of the developing cartilages with characteristic interruptions in the zones of joint formation, Bmp-2 expression was a positive marker for the articular interspaces. These data suggest that, in addition to the proposed role for BMP-2 and OP-1 in the establishment of the anteroposterior axis of the limb, they may also play direct roles in limb morphogenesis: (i) in regulating the amount and spatial distribution of the undifferentiated prechondrogenic mesenchyme and (ii) in controlling the location of the joints and the diaphyses of the cartilaginous primordia of the long bones once the chondrogenic aggregates are established.
This article has been cited by other articles:
|
|
 |
|
  C.-H. Hwang and D. K. Wu Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans Hum. Mol. Genet., March 15, 2008; 17(6): 844 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pajni-Underwood, C. P. Wilson, C. Elder, Y. Mishina, and M. Lewandoski BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling Development, June 15, 2007; 134(12): 2359 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Weatherbee, R. R. Behringer, J. J. Rasweiler IV, and L. A. Niswander Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification PNAS, October 10, 2006; 103(41): 15103 - 15107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Fukui, Y. Ikeda, T. Ohnuki, A. Hikita, S. Tanaka, S. Yamane, R. Suzuki, L. J. Sandell, and T. Ochi Pro-inflammatory Cytokine Tumor Necrosis Factor-{alpha} Induces Bone Morphogenetic Protein-2 in Chondrocytes via mRNA Stabilization and Transcriptional Up-regulation J. Biol. Chem., September 15, 2006; 281(37): 27229 - 27241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lu, G. Minowada, and G. R. Martin Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function Development, January 1, 2006; 133(1): 33 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lallemand, M.-A. Nicola, C. Ramos, A. Bach, C. S. Cloment, and B. Robert Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development Development, July 1, 2005; 132(13): 3003 - 3014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Meech, D. B. Edelman, F. S. Jones, and H. P. Makarenkova The homeobox transcription factor Barx2 regulates chondrogenesis during limb development Development, May 1, 2005; 132(9): 2135 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garciadiego-Cazares, C. Rosales, M. Katoh, and J. Chimal-Monroy Coordination of chondrocyte differentiation and joint formation by {alpha}5{beta}1 integrin in the developing appendicular skeleton Development, October 1, 2004; 131(19): 4735 - 4742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Virchenko, B. Skoglund, and P. Aspenberg Parecoxib Impairs Early Tendon Repair but Improves Later Remodeling Am. J. Sports Med., October 1, 2004; 32(7): 1743 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Knosp, V. Scott, H. P. Bachinger, and H. S. Stadler HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis Development, September 15, 2004; 131(18): 4581 - 4592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kida, Y. Maeda, T. Shiraishi, T. Suzuki, and T. Ogura Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis Development, September 1, 2004; 131(17): 4179 - 4187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Huang, A. Raya, P. DeJesus, S.-H. Chao, K. C. Quon, J. S. Caldwell, S. K. Chanda, J. C. Izpisua-Belmonte, and P. G. Schultz Identification of p53 regulators by genome-wide functional analysis PNAS, March 9, 2004; 101(10): 3456 - 3461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Bobick and W. M. Kulyk The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme J. Biol. Chem., February 6, 2004; 279(6): 4588 - 4595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hay, J. Lemonnier, O. Fromigue, H. Guenou, and P. J. Marie Bone Morphogenetic Protein Receptor IB Signaling Mediates Apoptosis Independently of Differentiation in Osteoblastic Cells J. Biol. Chem., January 16, 2004; 279(3): 1650 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Suzuki, D. Bachiller, Y. P. Chen, M. Kamikawa, H. Ogi, R. Haraguchi, Y. Ogino, Y. Minami, Y. Mishina, K. Ahn, et al. Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling Development, December 22, 2003; 130(25): 6209 - 6220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. J. van der Eerden, M. Karperien, and J. M. Wit Systemic and Local Regulation of the Growth Plate Endocr. Rev., December 1, 2003; 24(6): 782 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Morgan, S. B. Nguyen, V. Scott, and H. S. Stadler Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia Development, July 15, 2003; 130(14): 3095 - 3109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kiyono and M. Shibuya Bone Morphogenetic Protein 4 Mediates Apoptosis of Capillary Endothelial Cells during Rat Pupillary Membrane Regression Mol. Cell. Biol., July 1, 2003; 23(13): 4627 - 4636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-J. Shen, T. Nakamoto, K. Tsuji, A. Nifuji, K. Miyazono, T. Komori, H. Hirai, and M. Noda Negative Regulation of Bone Morphogenetic Protein/Smad Signaling by Cas-interacting Zinc Finger Protein in Osteoblasts J. Biol. Chem., August 9, 2002; 277(33): 29840 - 29846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pizette, C. Abate-Shen, and L. Niswander BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb Development, November 15, 2001; 128(22): 4463 - 4474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Minina, H. M. Wenzel, C. Kreschel, S. Karp, W. Gaffield, A. P. McMahon, and A. Vortkamp BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation Development, November 15, 2001; 128(22): 4523 - 4534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Arteaga-Solis, B. Gayraud, S. Y. Lee, L. Shum, L. Sakai, and F. Ramirez Regulation of limb patterning by extracellular microfibrils J. Cell Biol., July 23, 2001; 154(2): 275 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Montero, Y. Ganan, D. Macias, J. Rodriguez-Leon, J. J. Sanz-Ezquerro, R. Merino, J. Chimal-Monroy, M. A. Nieto, and J. M. Hurle Role of FGFs in the control of programmed cell death during limb development Development, June 1, 2001; 128(11): 2075 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Buxton, C. Edwards, C. W. Archer, and P. Francis-West Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S23 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Buxton, C. Edwards, C. W. Archer, and P. Francis-West Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development J. Bone Joint Surg. Am., March 1, 2001; 83(1_suppl_1): S23 - S30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Trousse, P. Esteve, and P. Bovolenta BMP4 Mediates Apoptotic Cell Death in the Developing Chick Eye J. Neurosci., February 15, 2001; 21(4): 1292 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Dahn and J. F. Fallon Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling Science, July 21, 2000; 289(5478): 438 - 441. [Abstract] [Full Text]
|
|
|
|
|
|
M. Iwamoto, Y. Higuchi, E. Koyama, M. Enomoto-Iwamoto, K. Kurisu, H. Yeh, W. R. Abrams, J. Rosenbloom, and M. Pacifici Transcription Factor ERG Variants and Functional Diversification of Chondrocytes during Limb Long Bone Development J. Cell Biol., July 11, 2000; 150(1): 27 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Monroe, D. F. Jin, and M. M. Sanders Estrogen Opposes the Apoptotic Effects of Bone Morphogenetic Protein 7 on Tissue Remodeling Mol. Cell. Biol., July 1, 2000; 20(13): 4626 - 4634. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. P. Morris, J. T. Oxford, G. B.M. Davies, B. F. Smoody, and D. R. Keene Developmentally Regulated Alternative Splicing of the {alpha}1(XI) Collagen Chain: Spatial and Temporal Segregation of Isoforms in the Cartilage of Fetal Rat Long Bones J. Histochem. Cytochem., June 1, 2000; 48(6): 725 - 742. [Abstract] [Full Text]
|
|
|
|
|
|
A. D. Weston, V. Rosen, R. A.S. Chandraratna, and T. M. Underhill Regulation of Skeletal Progenitor Differentiation by the BMP and Retinoid Signaling Pathways J. Cell Biol., February 21, 2000; 148(4): 679 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Shou, R. Murray, P. Rim, and A. Calof Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage Development, January 12, 2000; 127(24): 5403 - 5413. [Abstract] [PDF]
|
|
|
|
|
|
C Hartmann and C. Tabin Dual roles of Wnt signaling during chondrogenesis in the chicken limb Development, January 7, 2000; 127(14): 3141 - 3159. [Abstract] [PDF]
|
|
|
|
|
|
G Drossopoulou, K. Lewis, J. Sanz-Ezquerro, N Nikbakht, A. McMahon, C Hofmann, and C Tickle A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling Development, January 4, 2000; 127(7): 1337 - 1348. [Abstract] [PDF]
|
|
|
|
|
|
S. Yi, A Daluiski, R Pederson, V Rosen, and K. Lyons The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb Development, January 2, 2000; 127(3): 621 - 630. [Abstract] [PDF]
|
|
|
|
 |
|
 K. L. Eagleson and P. Levitt Complex Signaling Responsible for Molecular Regionalization of the Cerebral Cortex Cereb Cortex, September 1, 1999; 9(6): 562 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Murtaugh, J. H. Chyung, and A. B. Lassar Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling Genes & Dev., January 15, 1999; 13(2): 225 - 237. [Abstract] [Full Text]
|
|
|
|
|
|
R Merino, J Rodriguez-Leon, D Macias, Y Ganan, A. Economides, and J. Hurle The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb Development, January 12, 1999; 126(23): 5515 - 5522. [Abstract] [PDF]
|
|
|
|
|
|
N. Tsumaki, K. Tanaka, E. Arikawa-Hirasawa, T. Nakase, T. Kimura, J. T. Thomas, T. Ochi, F. P. Luyten, and Y. Yamada Role of CDMP-1 in Skeletal Morphogenesis: Promotion of Mesenchymal Cell Recruitment and Chondrocyte Differentiation J. Cell Biol., January 11, 1999; 144(1): 161 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Merino, D Macias, Y Ganan, J Rodriguez-Leon, A. Economides, C Rodriguez-Esteban, J. Izpisua-Belmonte, and J. Hurle Control of digit formation by activin signalling Development, January 5, 1999; 126(10): 2161 - 2170. [Abstract] [PDF]
|
|
|
|
|
|
S Pizette and L Niswander BMPs negatively regulate structure and function of the limb apical ectodermal ridge Development, January 2, 1999; 126(5): 883 - 894. [Abstract] [PDF]
|
|
|
|
|
|
R Crowe, J Zikherman, and L Niswander Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation Development, January 2, 1999; 126(5): 987 - 998. [Abstract] [PDF]
|
|
|
|
|
|
I Munoz-Sanjuan, B. Simandl, J. Fallon, and J Nathans Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development Development, January 1, 1999; 126(2): 409 - 421. [Abstract] [PDF]
|
|
|
|
|
|
L. J. Brunet, J. A. McMahon, A. P. McMahon, and R. M. Harland Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton Science, May 29, 1998; 280(5368): 1455 - 1457. [Abstract] [Full Text]
|
|
|
|
|
|
R. Jiang, Y. Lan, H. D. Chapman, C. Shawber, C. R. Norton, D. V. Serreze, G. Weinmaster, and T. Gridley Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice Genes & Dev., April 1, 1998; 12(7): 1046 - 1057. [Abstract] [Full Text]
|
|
|
|
|
|
D. Miller and R. Cagan Local induction of patterning and programmed cell death in the developing Drosophila retina Development, January 6, 1998; 125(12): 2327 - 2335. [Abstract] [PDF]
|
|
|
|
|
|
K Takahashi, G. Nuckolls, O Tanaka, I Semba, I Takahashi, R Dashner, L Shum, and H. Slavkin Adenovirus-mediated ectopic expression of Msx2 in even-numbered rhombomeres induces apoptotic elimination of cranial neural crest cells in ovo Development, January 5, 1998; 125(9): 1627 - 1635. [Abstract] [PDF]
|
|
|
|
|
|
J Jernvall, T Aberg, P Kettunen, S Keranen, and I Thesleff The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot Development, January 1, 1998; 125(2): 161 - 169. [Abstract] [PDF]
|
|
|
|
|
|
P.-X. Xu, J. Cheng, J. A. Epstein, and R. L. Maas Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function PNAS, October 28, 1997; 94(22): 11974 - 11979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Laufer, S. Pizette, H. Zou, O. E. Orozco, and L. Niswander BMP Expression in Duck Interdigital Webbing: A Reanalysis Science, October 10, 1997; 278(5336): 305 - 305. [Full Text]
|
|
|
|
|
|
H. Zou, R. Wieser, J. Massague, and L. Niswander Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage Genes & Dev., September 1, 1997; 11(17): 2191 - 2203. [Abstract] [Full Text] [PDF]
|
|
