spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Halder, G.
Right arrow Articles by Gehring, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Halder, G.
Right arrow Articles by Gehring, W. J.

Development, Vol 125, Issue 12 2181-2191, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development

G Halder, P Callaerts, S Flister, U Walldorf, U Kloter and WJ Gehring
Biozentrum, University of Basel, Klingelbergstr. 70, CH-4056 Basel, Switzerland.

The Drosophila Pax-6 gene eyeless acts high up in the genetic hierarchy involved in compound eye development and can direct the formation of extra eyes in ectopic locations. Here we identify sine oculis and eyes absent as two mediators of the eye-inducing activity of eyeless. We show that eyeless induces and requires the expression of both genes independently during extra eye development. During normal eye development, eyeless is expressed earlier than and is required for the expression of sine oculis and eyes absent, but not vice versa. Based on the results presented here and those of others, we propose a model in which eyeless induces the initial expression of both sine oculis and eyes absent in the eye disc. sine oculis and eyes absent then appear to participate in a positive feedback loop that regulates the expression of all three genes. In contrast to the regulatory interactions that occur in the developing eye disc, we also show that in the embryonic head, sine oculis acts in parallel to eyeless and twin of eyeless, a second Pax-6 gene from Drosophila. Recent studies in vertebrate systems indicate that the epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila.


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
R. Nakamura, R. Takeuchi, K.-i. Takata, K. Shimanouchi, Y. Abe, Y. Kanai, T. Ruike, A. Ihara, and K. Sakaguchi
TRF4 Is Involved in Polyadenylation of snRNAs in Drosophila melanogaster
Mol. Cell. Biol., November 1, 2008; 28(21): 6620 - 6631.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. R. Braid and E. M. Verheyen
Drosophila Nemo Promotes Eye Specification Directed by the Retinal Determination Gene Network
Genetics, September 1, 2008; 180(1): 283 - 299.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Wu, S. Katiyar, A. Li, M. Liu, X. Ju, V. M. Popov, X. Jiao, M. P. Lisanti, A. Casola, and R. G. Pestell
Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8
PNAS, May 13, 2008; 105(19): 6924 - 6929.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Prince, T. Katsuyama, Y. Oshima, S. Plaza, D. Resendez-Perez, M. Berry, S. Kurata, and W. J. Gehring
The YPWM motif links Antennapedia to the basal transcriptional machinery
Development, May 1, 2008; 135(9): 1669 - 1679.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
W. Cao, H.-J. Song, T. Gangi, A. Kelkar, I. Antani, D. Garza, and M. Konsolaki
Identification of Novel Genes That Modify Phenotypes Induced by Alzheimer's {beta}-Amyloid Overexpression in Drosophila
Genetics, March 1, 2008; 178(3): 1457 - 1471.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K.-Q. Gong, A. R. Yallowitz, H. Sun, G. R. Dressler, and D. M. Wellik
A Hox-Eya-Pax Complex Regulates Early Kidney Developmental Gene Expression
Mol. Cell. Biol., November 1, 2007; 27(21): 7661 - 7668.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Matsuno, H. Kose, M. Okabe, and Y. Hiromi
TFIIH controls developmentally-regulated cell cycle progression as a holocomplex.
Genes Cells, November 1, 2007; 12(11): 1289 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
G. Schlosser
How old genes make a new head: redeployment of Six and Eya genes during the evolution of vertebrate cranial placodes
Integr. Comp. Biol., September 1, 2007; 47(3): 343 - 359.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Zhang, S. Ranade, C. Q. Cai, C. Clouser, and F. Pignoni
Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So
Development, December 15, 2006; 133(24): 4881 - 4889.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Bras-Pereira, J. Bessa, and F. Casares
Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila
Development, November 1, 2006; 133(21): 4145 - 4149.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Wu, A. Li, M. Rao, M. Liu, V. Dailey, Y. Yang, D. Di Vizio, C. Wang, M. P. Lisanti, G. Sauter, et al.
DACH1 Is a Cell Fate Determination Factor That Inhibits Cyclin D1 and Breast Tumor Growth.
Mol. Cell. Biol., October 1, 2006; 26(19): 7116 - 7129.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
E. J. Ostrin, Y. Li, K. Hoffman, J. Liu, K. Wang, L. Zhang, G. Mardon, and R. Chen
Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless
Genome Res., April 1, 2006; 16(4): 466 - 476.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Bessa and F. Casares
Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila
Development, November 15, 2005; 132(22): 5011 - 5020.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Katsuyama, T. Sugawara, M. Tatsumi, Y. Oshima, W. J. Gehring, T. Aigaki, and S. Kurata
Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification
PNAS, November 1, 2005; 102(44): 15918 - 15923.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Singh, J. Chan, J. J. Chern, and K.-W. Choi
Genetic Interaction of Lobe With Its Modifiers in Dorsoventral Patterning and Growth of the Drosophila Eye
Genetics, September 1, 2005; 171(1): 169 - 183.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. S. Pappu, E. J. Ostrin, B. W. Middlebrooks, B. T. Sili, R. Chen, M. R. Atkins, R. Gibbs, and G. Mardon
Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund
Development, June 15, 2005; 132(12): 2895 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Pauli, M. Seimiya, J. Blanco, and W. J. Gehring
Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog
Development, June 15, 2005; 132(12): 2771 - 2782.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Grifone, J. Demignon, C. Houbron, E. Souil, C. Niro, M. J. Seller, G. Hamard, and P. Maire
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo
Development, May 1, 2005; 132(9): 2235 - 2249.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. J. Silver and I. Rebay
Signaling circuitries in development: insights from the retinal determination gene network
Development, January 1, 2005; 132(1): 3 - 13.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Miguel-Aliaga, D. W. Allan, and S. Thor
Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification
Development, December 1, 2004; 131(23): 5837 - 5848.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. P. Kumar, T. Jamal, A. Doetsch, F. R. Turner, and J. B. Duffy
CREB Binding Protein Functions During Successive Stages of Eye Development in Drosophila
Genetics, October 1, 2004; 168(2): 877 - 893.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. E. Treisman
How to make an eye
Development, August 15, 2004; 131(16): 3823 - 3827.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Punzo, S. Plaza, M. Seimiya, P. Schnupf, S. Kurata, J. Jaeger, and W. J. Gehring
Functional divergence between eyeless and twin of eyeless in Drosophila melanogaster
Development, August 15, 2004; 131(16): 3943 - 3953.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Buttiglieri, M. C. Deregibus, S. Bravo, P. Cassoni, R. Chiarle, B. Bussolati, and G. Camussi
Role of Pax2 in Apoptosis Resistance and Proinvasive Phenotype of Kaposi's Sarcoma Cells
J. Biol. Chem., February 6, 2004; 279(6): 4136 - 4143.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Ozaki, K. Nakamura, J.-i. Funahashi, K. Ikeda, G. Yamada, H. Tokano, H.-o. Okamura, K. Kitamura, S. Muto, H. Kotaki, et al.
Six1 controls patterning of the mouse otic vesicle
Development, February 1, 2004; 131(3): 551 - 562.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. M. Sivak, J. A. West-Mays, A. Yee, T. Williams, and M. E. Fini
Transcription Factors Pax6 and AP-2{alpha} Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B
Mol. Cell. Biol., January 1, 2004; 24(1): 245 - 257.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
F. Janody, J. D. Lee, N. Jahren, D. J. Hazelett, A. Benlali, G. I. Miura, I. Draskovic, and J. E. Treisman
A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development
Genetics, January 1, 2004; 166(1): 187 - 200.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Singh and K.-W. Choi
Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventral
Development, December 22, 2003; 130(25): 6351 - 6360.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris
Specification of the vertebrate eye by a network of eye field transcription factors
Development, November 1, 2003; 130(21): 5155 - 5167.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. D. S. Dong, S. V. Todi, D. F. Eberl, and G. Boekhoff-Falk
Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes
PNAS, September 2, 2003; 100(18): 10293 - 10298.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. J. Silver, E. L. Davies, L. Doyon, and I. Rebay
Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network
Mol. Cell. Biol., September 1, 2003; 23(17): 5989 - 5999.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Zheng, L. Huang, Z.-B. Wei, D. Silvius, B. Tang, and P.-X. Xu
The role of Six1 in mammalian auditory system development
Development, September 1, 2003; 130(17): 3989 - 4000.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P.-X. Xu, W. Zheng, L. Huang, P. Maire, C. Laclef, and D. Silvius
Six1 is required for the early organogenesis of mammalian kidney
Development, July 15, 2003; 130(14): 3085 - 3094.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. D. Mathies, S. T. Henderson, and J. Kimble
The C. elegans Hand gene controls embryogenesis and early gonadogenesis
Development, July 1, 2003; 130(13): 2881 - 2892.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun
Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development
Development, July 1, 2003; 130(13): 2939 - 2951.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. S. Pappu, R. Chen, B. W. Middlebrooks, C. Woo, U. Heberlein, and G. Mardon
Mechanism of hedgehog signaling during Drosophila eye development
Development, July 1, 2003; 130(13): 3053 - 3062.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Y. Nagai, N. Fujikake, K. Ohno, H. Higashiyama, H. A. Popiel, J. Rahadian, M. Yamaguchi, W. J. Strittmatter, J. R. Burke, and T. Toda
Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila
Hum. Mol. Genet., June 1, 2003; 12(11): 1253 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. L. Kelley and M. I. Kuroda
The Drosophila roX1 RNA Gene Can Overcome Silent Chromatin by Recruiting the Male-Specific Lethal Dosage Compensation Complex
Genetics, June 1, 2003; 164(2): 565 - 574.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kango-Singh, R. Nolo, C. Tao, P. Verstreken, P. R. Hiesinger, H. J. Bellen, and G. Halder
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
Development, March 14, 2003; 129(24): 5719 - 5730.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Singh, M. Kango-Singh, and Y. H. Sun
Eye suppression, a novel function of teashirt, requires Wingless signaling
Development, March 11, 2003; 129(18): 4271 - 4280.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. M. Cadigan, A. D. Jou, and R. Nusse
Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless
Development, March 9, 2003; 129(14): 3393 - 3402.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. D. S. Dong, J. S. Dicks, and G. Panganiban
Distal-less and homothorax regulate multiple targets to pattern the Drosophila antenna
Development, March 6, 2003; 129(8): 1967 - 1974.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Kronhamn, E. Frei, M. Daube, R. Jiao, Y. Shi, M. Noll, and A. Rasmuson-Lestander
Headless flies produced by mutations in the paralogous Pax6 genes eyeless and twin of eyeless
Development, March 4, 2003; 129(4): 1015 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. J. Frank, B. A. Edgar, and M. B. Roth
The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis
Development, March 3, 2003; 129(2): 399 - 407.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Benassayag, S. Plaza, P. Callaerts, J. Clements, Y. Romeo, W. J. Gehring, and D. L. Cribbs
Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development
Development, February 1, 2003; 130(3): 575 - 586.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Ikeda, Y. Watanabe, H. Ohto, and K. Kawakami
Molecular Interaction and Synergistic Activation of a Promoter by Six, Eya, and Dach Proteins Mediated through CREB Binding Protein
Mol. Cell. Biol., October 1, 2002; 22(19): 6759 - 6766.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. M. Wellik, P. J. Hawkes, and M. R. Capecchi
Hox11 paralogous genes are essential for metanephric kidney induction
Genes & Dev., June 1, 2002; 16(11): 1423 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C.-M. Li, M. Guo, A. Borczuk, C. A. Powell, M. Wei, H. M. Thaker, R. Friedman, U. Klein, and B. Tycko
Gene Expression in Wilms' Tumor Mimics the Earliest Committed Stage in the Metanephric Mesenchymal-Epithelial Transition
Am. J. Pathol., June 1, 2002; 160(6): 2181 - 2190.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
V. van Heyningen and K. A. Williamson
PAX6 in sensory development
Hum. Mol. Genet., May 15, 2002; 11(10): 1161 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Clark, B. E. Fee, and J. L. Cleveland
Misexpression of the Eyes Absent Family Triggers the Apoptotic Program
J. Biol. Chem., January 25, 2002; 277(5): 3560 - 3567.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Baonza and M. Freeman
Control of Drosophila eye specification by Wingless signalling
Development, January 12, 2002; 129(23): 5313 - 5322.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Punzo, M. Seimiya, S. Flister, W. J. Gehring, and S. Plaza
Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer
Development, January 2, 2002; 129(3): 625 - 634.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Bernier, W. Vukovich, L. Neidhardt, B. G. Herrmann, and P. Gruss
Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium
Development, October 15, 2001; 128(20): 3987 - 3994.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Jiao, M. Daube, H. Duan, Y. Zou, E. Frei, and M. Noll
Headless flies generated by developmental pathway interference
Development, September 1, 2001; 128(17): 3307 - 3319.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Punzo, S. Kurata, and W. J. Gehring
The eyeless homeodomain is dispensable for eye development in Drosophila
Genes & Dev., July 1, 2001; 15(13): 1716 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. J. Davis, W. Shen, Y. I. Sandler, M. Amoui, P. Purcell, R. Maas, C.-N. Ou, H. Vogel, A. L. Beaudet, and G. Mardon
Dach1 Mutant Mice Bear No Gross Abnormalities in Eye, Limb, and Brain Development and Exhibit Postnatal Lethality
Mol. Cell. Biol., March 1, 2001; 21(5): 1484 - 1490.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
J. Lee and J. Treisman
The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc
Development, January 5, 2001; 128(9): 1519 - 1529.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J Treisman
Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development
Development, January 2, 2001; 128(4): 603 - 615.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
R. Ashery-Padan, T. Marquardt, X. Zhou, and P. Gruss
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
Genes & Dev., November 1, 2000; 14(21): 2701 - 2711.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
E. Torban, M. R. Eccles, J. Favor, and P. R. Goodyer
PAX2 Suppresses Apoptosis in Renal Collecting Duct Cells
Am. J. Pathol., September 1, 2000; 157(3): 833 - 842.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
Q. T. Bui, J. E. Zimmerman, H. Liu, and N. M. Bonini
Molecular Analysis of Drosophila eyes absent Mutants Reveals Features of the Conserved Eya Domain
Genetics, June 1, 2000; 155(2): 709 - 720.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Pineda, J. Gonzalez, P. Callaerts, K. Ikeo, W. J. Gehring, and E. Salo
Special Feature: Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians
PNAS, April 25, 2000; 97(9): 4525 - 4529.
[Abstract] [Full Text] [PDF]

Home page