|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 12 2327-2335, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
DT Miller and RL Cagan
Washington University School of Medicine, Department of Molecular Biology and Pharmacology, Box 8103, St. Louis, MO 63110, USA.
Local cell signaling can pattern the nervous system by directing cell fates, including programmed cell death. In the developing Drosophila retina, programmed cell death is used to remove excess cells between ommatidia. Cell ablation revealed the source and position of signals required for regulating the pattern of programmed cell death among these interommatidial cells. Two types of signals regulate this patterning event. Notch-mediated signals between interommatidial precursors result in removal of unneeded cells. Cone cells and primary pigment cells oppose this signal by supplying a 'life'-promoting activity; evidence is provided that this signal occurs through localized activation of the EGF Receptor/Ras pathway. Together, these signals refine the highly regular pattern observed in the adult retina.
This article has been cited by other articles:
|
|
 |
|
  C. E. Protzer, I. Wech, and A. C. Nagel Hairless induces cell death by downregulation of EGFR signalling activity J. Cell Sci., October 1, 2008; 121(19): 3167 - 3176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. del Alamo and M. Mlodzik Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor Development, September 1, 2008; 135(17): 2895 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Johnson, M. J. Seppa, and R. L. Cagan The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning J. Cell Biol., March 24, 2008; 180(6): 1191 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Krieser, F. E. Moore, D. Dresnek, B. J. Pellock, R. Patel, A. Huang, C. Brachmann, and K. White The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis Development, July 1, 2007; 134(13): 2407 - 2414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Cordero, D. E. Larson, C. R. Craig, R. Hays, and R. Cagan Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina Development, May 15, 2007; 134(10): 1861 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nagaraj and U. Banerjee Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye Development, March 1, 2007; 134(5): 825 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, X. Shi, and K.-W. Choi Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development, December 1, 2006; 133(23): 4771 - 4781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Lim and A. Tomlinson Organization of the peripheral fly eye: the roles of Snail family transcription factors in peripheral retinal apoptosis Development, September 15, 2006; 133(18): 3529 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-M. Herz, Z. Chen, H. Scherr, M. Lackey, C. Bolduc, and A. Bergmann vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis Development, May 15, 2006; 133(10): 1871 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kent, E. W. Bush, and J. E. Hooper Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development, May 1, 2006; 133(10): 2001 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Read, P. J. Goodfellow, E. R. Mardis, N. Novak, J. R. Armstrong, and R. L. Cagan A Drosophila Model of Multiple Endocrine Neoplasia Type 2 Genetics, November 1, 2005; 171(3): 1057 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Muller, S. J. Kugler, A. Preiss, D. Maier, and A. C. Nagel Genetic Modifier Screens on Hairless Gain-of-Function Phenotypes Reveal Genes Involved in Cell Differentiation, Cell Growth and Apoptosis in Drosophila melanogaster Genetics, November 1, 2005; 171(3): 1137 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Grzeschik and E. Knust IrreC/rst-mediated cell sorting during Drosophila pupal eye development depends on proper localisation of DE-cadherin Development, May 1, 2005; 132(9): 2035 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. Lin, A. Rogulja, and K. M. Cadigan Wingless eliminates ommatidia from the edge of the developing eye through activation of apoptosis Development, May 15, 2004; 131(10): 2409 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Hoyne Notch signaling in the immune system J. Leukoc. Biol., December 1, 2003; 74(6): 971 - 981. [Abstract] [Full Text]
|
|
|
|
|
|
M. G. Voas and I. Rebay The Novel Plant Homeodomain Protein Rhinoceros Antagonizes Ras Signaling in the Drosophila Eye Genetics, December 1, 2003; 165(4): 1993 - 2006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Morey, M. Corominas, and F. Serras DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila J. Cell Sci., November 15, 2003; 116(22): 4597 - 4604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Brown and M. Freeman Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye Development, November 15, 2003; 130(22): 5401 - 5412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Peterson, G. E. Carney, B. J. Taylor, and K. White reaper is required for neuroblast apoptosis during Drosophila development Development, March 5, 2003; 129(6): 1467 - 1476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gorski and M. Marra Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila Physiol Genomics, May 10, 2002; 9(2): 59 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Yu, S. J. Yoo, L. Yang, C. Zapata, A. Srinivasan, B. A. Hay, and N. E. Baker A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye Development, January 7, 2002; 129(13): 3269 - 3278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Sriuranpong, M. W. Borges, R. K. Ravi, D. R. Arnold, B. D. Nelkin, S. B. Baylin, and D. W. Ball Notch Signaling Induces Cell Cycle Arrest in Small Cell Lung Cancer Cells Cancer Res., April 1, 2001; 61(7): 3200 - 3205. [Abstract] [Full Text]
|
|
|
|
|
|
S. B. Tanenbaum, S. M. Gorski, J. C. Rusconi, and R. L. Cagan A Screen for Dominant Modifiers of the irreC-rst Cell Death Phenotype in the Developing Drosophila Retina Genetics, September 1, 2000; 156(1): 205 - 217. [Abstract] [Full Text]
|
|
|
|
|
|
A. Taguchi, K. Sawamoto, and H. Okano Mutations Modulating the Argos-Regulated Signaling Pathway in Drosophila Eye Development Genetics, April 1, 2000; 154(4): 1639 - 1648. [Abstract] [Full Text]
|
|
|
|
|
|
I. Rebay, F. Chen, F. Hsiao, P. A. Kolodziej, B. H. Kuang, T. Laverty, C. Suh, M. Voas, A. Williams, and G. M. Rubin A Genetic Screen for Novel Components of the Ras/Mitogen-Activated Protein Kinase Signaling Pathway That Interact With the yan Gene of Drosophila Identifies split ends, a New RNA Recognition Motif-Containing Protein Genetics, February 1, 2000; 154(2): 695 - 712. [Abstract] [Full Text]
|
|
|
|
|
|
T. Maynard, Y Wakamatsu, and J. Weston Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors Development, January 11, 2000; 127(21): 4561 - 4572. [Abstract] [PDF]
|
|
|
|
|
|
P zur Lage and A. Jarman Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors Development, January 6, 1999; 126(14): 3149 - 3157. [Abstract] [PDF]
|
|
|
|
|
|
S. Spencer, P. Powell, D. Miller, and R. Cagan Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina Development, January 12, 1998; 125(23): 4777 - 4790. [Abstract] [PDF]
|
|
|
|
|
|
J. Skeath The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo Development, January 9, 1998; 125(17): 3301 - 3312. [Abstract] [PDF]
|
|
