|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 15 2803-2811, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
Z Hardcastle, R Mo, CC Hui and PT Sharpe
Department of Craniofacial Development, UMDS, Guy's Hospital, London Bridge, London SE1 9RT, UK.
The expression of genes involved in the Sonic Hedgehog signalling pathway, including Shh, Ptc, Smo, Gli1, Gli2 and Gli3, were found to be expressed in temporal and spatial patterns during early murine tooth development, suggestive of a role in early tooth germ initiation and subsequent epithelial-mesenchymal interactions. Of these Ptc, Smo, Gli1, Gli2 and Gli3 were expressed in epithelium and mesenchyme whereas Shh was only detected in epithelium. This suggests that Shh is involved in both lateral (epithelial-mesenchymal) and planar (epithelial-epithelial) signalling in early tooth development. Ectopic application of Shh protein to mandibular mesenchyme induced the expression of Ptc and Gli1. Addition of exogenous Shh protein directly into early tooth germs and adjacent to tooth germs, resulted in abnormal epithelial invagination, indicative of a role for Shh in epithelial cell proliferation. In order to assess the possible role of this pathway, tooth development in Gli2 and Gli3 mutant embryos was investigated. Gli2 mutants were found to have abnormal development of maxillary incisors, probably resulting from a mild holoprosencephaly, whereas Gli3 mutants had no major tooth abnormalities. Gli2/Gli3 double homozygous mutants did not develop any normal teeth and did not survive beyond embryonic day 14.5; however, Gli2(-/-); Gli3(+/-) did survive until birth and had small molars and mandibular incisors whereas maxillary incisor development was arrested as a rudimentary epithelial thickening. These results show an essential role for Shh signalling in tooth development that involves functional redundancy of downstream Gli genes.
This article has been cited by other articles:
|
|
 |
|
  E. Matalova, J. Fleischmannova, P.T. Sharpe, and A.S. Tucker Tooth Agenesis: from Molecular Genetics to Molecular Dentistry J. Dent. Res., July 1, 2008; 87(7): 617 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Haraguchi, J. Motoyama, H. Sasaki, Y. Satoh, S. Miyagawa, N. Nakagata, A. Moon, and G. Yamada Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling Development, February 1, 2007; 134(3): 525 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pummila, I. Fliniaux, R. Jaatinen, M. J. James, J. Laurikkala, P. Schneider, I. Thesleff, and M. L. Mikkola Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression Development, January 1, 2007; 134(1): 117 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.M. Mitchell, D.M. Hicklin, P.M. Doughty, J.H. Hicklin, J.W. Dickert Jr., S.M. Tolbert, R. Peterkova, and M.J. Kern The Prx1 Homeobox Gene is Critical for Molar Tooth Morphogenesis. J. Dent. Res., October 1, 2006; 85(10): 888 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Hatsell and P. Cowin Gli3-mediated repression of Hedgehog targets is required for normal mammary development Development, September 15, 2006; 133(18): 3661 - 3670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-M. Gu, H.-S. Zhao, L.-S. Sun, and T.-J. Li PTCH Mutations in Sporadic and Gorlin-syndrome-related Odontogenic Keratocysts J. Dent. Res., September 1, 2006; 85(9): 859 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Grachtchouk, J. Liu, A. Wang, L. Wei, C. K. Bichakjian, J. Garlick, A. F. Paulino, T. Giordano, and A. A. Dlugosz Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans Am. J. Pathol., September 1, 2006; 169(3): 806 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Stock, W. R. Jackman, and J. Trapani Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes Development, August 15, 2006; 133(16): 3127 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakatomi, I. Morita, K. Eto, and M.S. Ota Sonic Hedgehog Signaling is Important in Tooth Root Development. J. Dent. Res., May 1, 2006; 85(5): 427 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Laurikkala, M. L. Mikkola, M. James, M. Tummers, A. A. Mills, and I. Thesleff p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation Development, April 15, 2006; 133(8): 1553 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells J. Biol. Chem., April 22, 2005; 280(16): 15700 - 15708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Hutchin, M. S.T. Kariapper, M. Grachtchouk, A. Wang, L. Wei, D. Cummings, J. Liu, L. E. Michael, A. Glick, and A. A. Dlugosz Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle Genes & Dev., January 15, 2005; 19(2): 214 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kettunen, S. Loes, T. Furmanek, K. Fjeld, I. H. Kvinnsland, O. Behar, T. Yagi, H. Fujisawa, S. Vainio, M. Taniguchi, et al. Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgf{beta}1 regulate semaphorin 3a expression in the dental mesenchyme Development, January 15, 2005; 132(2): 323 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Traiffort, C. Dubourg, H. Faure, D. Rognan, S. Odent, M.-R. Durou, V. David, and M. Ruat Functional Characterization of Sonic Hedgehog Mutations Associated with Holoprosencephaly J. Biol. Chem., October 8, 2004; 279(41): 42889 - 42897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Cobourne, I. Miletich, and P. T. Sharpe Restriction of sonic hedgehog signalling during early tooth development Development, June 15, 2004; 131(12): 2875 - 2885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Buttitta, R. Mo, C.-C. Hui, and C.-M. Fan Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction Development, December 22, 2003; 130(25): 6233 - 6243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Roessler, Y.-Z. Du, J. L. Mullor, E. Casas, W. P. Allen, G. Gillessen-Kaesbach, E. R. Roeder, J. E. Ming, A. R. i Altaba, and M. Muenke Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features PNAS, November 11, 2003; 100(23): 13424 - 13429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Mitsiadis, I. Angeli, C. James, U. Lendahl, and P. T. Sharpe Role of Islet1 in the patterning of murine dentition Development, September 15, 2003; 130(18): 4451 - 4460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. O. Walterhouse, M. L.G. Lamm, E. Villavicencio, and P. M. Iannaccone Emerging Roles for Hedgehog-Patched-Gli Signal Transduction in Reproduction Biol Reprod, July 1, 2003; 69(1): 8 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Mitsiadis, Y. Cheraud, P. Sharpe, and J. Fontaine-Perus Development of teeth in chick embryos after mouse neural crest transplantations PNAS, May 27, 2003; 100(11): 6541 - 6545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Roessler and M. Muenke How a Hedgehog might see holoprosencephaly Hum. Mol. Genet., April 2, 2003; 12(90001): R15 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Miletich and P. T. Sharpe Normal and abnormal dental development Hum. Mol. Genet., April 2, 2003; 12(90001): R69 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Steele-Perkins, K. G. Butz, G. E. Lyons, M. Zeichner-David, H.-J. Kim, M.-I. Cho, and R. M. Gronostajski Essential Role for NFI-C/CTF Transcription-Replication Factor in Tooth Root Development Mol. Cell. Biol., February 1, 2003; 23(3): 1075 - 1084. [Abstract] [Full Text]
|
|
|
|
|
|
K. Kratochwil, J. Galceran, S. Tontsch, W. Roth, and R. Grosschedl FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1-/- mice Genes & Dev., December 15, 2002; 16(24): 3173 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes & Dev., November 15, 2002; 16(22): 2865 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.C. Barreto, A.E. Bale, L. De Marco, and R.S. Gomez Immunolocalization of PTCH Protein in Odontogenic Cysts and Tumors J. Dent. Res., November 1, 2002; 81(11): 757 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sheng, S. Goich, A. Wang, M. Grachtchouk, L. Lowe, R. Mo, K. Lin, F. J. de Sauvage, H. Sasaki, C.-c. Hui, et al. Dissecting the Oncogenic Potential of Gli2: Deletion of an NH2-Terminal Fragment Alters Skin Tumor Phenotype Cancer Res., September 15, 2002; 62(18): 5308 - 5316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Bailey, L. Milenkovic, M. P. Scott, J. F. Collawn, and R. L. Johnson Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts J. Biol. Chem., September 6, 2002; 277(37): 33632 - 33640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, Y. Song, X. Zhao, X. Zhang, C. Fermin, and Y. Chen Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis Development, September 1, 2002; 129(17): 4135 - 4146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Heikinheimo, K.J. Jee, T. Niini, Y. Aalto, R.-P. Happonen, I. Leivo, and S. Knuutila Gene Expression Profiling of Ameloblastoma and Human Tooth Germ by Means of a cDNA Microarray J. Dent. Res., August 1, 2002; 81(8): 525 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gritli-Linde, M. Bei, R. Maas, X. M. Zhang, A. Linde, and A. P. McMahon Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization Development, January 12, 2002; 129(23): 5323 - 5337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Bai and A. L. Joyner Gli1 can rescue the in vivo function of Gli2 Development, December 15, 2001; 128(24): 5161 - 5172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Haraguchi, R. Mo, C.-c. Hui, J. Motoyama, S. Makino, T. Shiroishi, W. Gaffield, and G. Yamada Unique functions of Sonic hedgehog signaling during external genitalia development Development, November 1, 2001; 128(21): 4241 - 4250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz GLI-2 Modulates Retroviral Gene Expression J. Virol., March 1, 2001; 75(5): 2301 - 2313. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Clark, K. K. Garland, and L. D. Russell Desert hedgehog (Dhh) Gene Is Required in the Mouse Testis for Formation of Adult-Type Leydig Cells and Normal Development of Peritubular Cells and Seminiferous Tubules Biol Reprod, December 1, 2000; 63(6): 1825 - 1838. [Abstract] [Full Text]
|
|
|
|
|
|
L. Sarkar, M. Cobourne, S. Naylor, M. Smalley, T. Dale, and P. T. Sharpe Special Feature: Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development PNAS, April 25, 2000; 97(9): 4520 - 4524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dassule, P Lewis, M Bei, R Maas, and A. McMahon Sonic hedgehog regulates growth and morphogenesis of the tooth Development, January 11, 2000; 127(22): 4775 - 4785. [Abstract] [PDF]
|
|
|
|
|
|
Y Zhang, Z Zhang, X Zhao, X Yu, Y Hu, B Geronimo, S. Fromm, and Y. Chen A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ Development, January 4, 2000; 127(7): 1431 - 1443. [Abstract] [PDF]
|
|
|
|
|
|
B. Thomas, J. Liu, J. Rubenstein, and P. Sharpe Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch Development, January 1, 2000; 127(2): 217 - 224. [Abstract] [PDF]
|
|
|
|
|
|
C. Ferguson, A. Tucker, and P. Sharpe Temporospatial cell interactions regulating mandibular and maxillary arch patterning Development, January 1, 2000; 127(2): 403 - 412. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Suthers, S. Smith, and S. Springbett Skewed sex ratios in familial holoprosencephaly and in people with isolated single maxillary central incisor J. Med. Genet., December 1, 1999; 36(12): 924 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Martyn. T. Cobourne The Genetic Control of Early Odontogenesis J. Orthod., March 1, 1999; 26(1): 21 - 28. [Full Text] [PDF]
|
|
|
|
|
|
A. Tucker, G Yamada, M Grigoriou, V Pachnis, and P. Sharpe Fgf-8 determines rostral-caudal polarity in the first branchial arch Development, January 1, 1999; 126(1): 51 - 61. [Abstract] [PDF]
|
|
|
|
|
|
A. Tucker, A Al Khamis, C. Ferguson, I Bach, M. Rosenfeld, and P. Sharpe Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development Development, January 1, 1999; 126(2): 221 - 228. [Abstract] [PDF]
|
|
|
|
|
|
C. A. Ferguson, A. S. Tucker, L. Christensen, A. L. Lau, M. M. Matzuk, and P. T. Sharpe Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition Genes & Dev., August 15, 1998; 12(16): 2636 - 2649. [Abstract] [Full Text]
|
|
