|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 15 2915-2923, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
T Kunisada, H Yoshida, H Yamazaki, A Miyamoto, H Hemmi, E Nishimura, LD Shultz, S Nishikawa and S Hayashi
Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Nishi-machi 86, Yonago 683, Japan. tkunisad@grape.med.tottori-u.ac.jp
Mutations at the murine dominant white spotting (KitW) and steel (MgfSl) loci, encoding c-Kit receptor kinase and its ligand respectively, exert developmental defects on hematopoietic cells, melanocytes, germ cells and interstitial cells of Cajal. The expression patterns of steel factor (SLF) observed in the skin and gonads suggest that SLF mediates a migratory or a chemotactic signal for c-Kit-expressing stem cells (melanocyte precursors and primordial germ cells). By targeting expression of SLF to epidermal keratinocytes in mice, we observed extended distribution of melanocytes in a number of sites including oral epithelium and footpads where neither melanocytes nor their precursors are normally detected. In addition, enlarged pigmented spots of KitW and other spotting mutant mice were observed in the presence of the SLF transgene. These results provide direct evidence that SLF stimulates migration of melanocytes in vivo. We also present data suggesting that SLF does not simply support survival and proliferation of melanocytes but also promotes differentiation of these cells. Unexpectedly, melanocyte stem cells independent of the c-Kit signal were maintained in the skin of the SLF transgenic mice. After the elimination of c-Kit-dependent melanoblasts by function-blocking anti-c-Kit antibody, these stem cells continued to proliferate and differentiate into mature melanocytes. These melanoblasts are able to migrate to cover most of the epidermis after several months. The SLF transgenic mice described in this report will be useful in the study of melanocyte biology.
This article has been cited by other articles:
|
|
 |
|
  M. L. Harris, R. Hall, and C. A. Erickson Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition Development, December 15, 2008; 135(24): 4113 - 4122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-I. Nishikawa, M. Osawa, S. Yonetani, S. Torikai-Nishikawa, and R. Freter Niche Required for Inducing Quiescent Stem Cells Cold Spring Harb Symp Quant Biol, November 6, 2008; (2008) sqb.2008.73.024v1. [Abstract] [PDF]
|
|
|
|
 |
|
 V. A Randall, T. J Jenner, N. A Hibberts, I. O De Oliveira, and T. Vafaee Stem cell factor/c-Kit signalling in normal and androgenetic alopecia hair follicles J. Endocrinol., April 1, 2008; 197(1): 11 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lutz, M. Rosenberg, F. Kiessling, V. Eckstein, T. Heger, J. Krebs, A. D. Ho, H. A. Katus, and N. Frey Local injection of stem cell factor (SCF) improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells Cardiovasc Res, January 1, 2008; 77(1): 143 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Routhouska, A. C. Gilliam, and P. Mirmirani Hair Depigmentation During Chemotherapy With a Class III/V Receptor Tyrosine Kinase Inhibitor. Arch Dermatol, November 1, 2006; 142(11): 1477 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yoshino, H. Yamazaki, L. D. Shultz, and S.-I. Hayashi Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes Int. Immunol., November 1, 2006; 18(11): 1541 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fang, K. Leishear, T. K. Nguyen, R. Finko, K. Cai, M. Fukunaga, L. Li, P. A. Brafford, A. N. Kulp, X. Xu, et al. Defining the Conditions for the Generation of Melanocytes from Human Embryonic Stem Cells Stem Cells, July 1, 2006; 24(7): 1668 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.J. Hutt, E.A. McLaughlin, and M.K. Holland Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis Mol. Hum. Reprod., February 1, 2006; 12(2): 61 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fazel, L. Chen, R. D. Weisel, D. Angoulvant, C. Seneviratne, A. Fazel, P. Cheung, J. Lam, P. W.M. Fedak, T. M. Yau, et al. Cell transplantation preserves cardiac function after infarction by infarct stabilization: Augmentation by stem cell factor J. Thorac. Cardiovasc. Surg., November 1, 2005; 130(5): 1310 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Leri, J. Kajstura, and P. Anversa Cardiac Stem Cells and Mechanisms of Myocardial Regeneration Physiol Rev, October 1, 2005; 85(4): 1373 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-B. Ruan, N. Zhang, and X. Gao Identification of a Novel Point Mutation of Mouse Proto-Oncogene c-kit Through N-Ethyl-N-nitrosourea Mutagenesis Genetics, February 1, 2005; 169(2): 819 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Paulhe, B. A. Imhof, and B. Wehrle-Haller A Specific Endoplasmic Reticulum Export Signal Drives Transport of Stem Cell Factor (Kitl) to the Cell Surface J. Biol. Chem., December 31, 2004; 279(53): 55545 - 55555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kato, K. Takeda, Y. Kawamoto, T. Tsuzuki, K. Hossain, A. Tamakoshi, T. Kunisada, Y. Kambayashi, K. Ogino, H. Suzuki, et al. c-Kit-Targeting Immunotherapy for Hereditary Melanoma in a Mouse Model Cancer Res., February 1, 2004; 64(3): 801 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kumamoto, D. Shalhevet, H. Matsue, M. E. Mummert, B. R. Ward, J. V. Jester, and A. Takashima Hair follicles serve as local reservoirs of skin mast cell precursors Blood, September 1, 2003; 102(5): 1654 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Maderspacher and C. Nusslein-Volhard Formation of the adult pigment pattern in zebrafish requires leopard and obelix dependent cell interactions Development, August 1, 2003; 130(15): 3447 - 3457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yoshino, H. Yamazaki, H. Nakano, T. Kakiuchi, K. Ryoke, T. Kunisada, and S.-I. Hayashi Distinct antigen trafficking from skin in the steady and active states Int. Immunol., June 1, 2003; 15(6): 773 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Parichy and J. M. Turner Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development Development, March 1, 2003; 130(5): 817 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Fitch, K. A. McGowan, C. D. van Raamsdonk, H. Fuchs, D. Lee, A. Puech, Y. Herault, D. W. Threadgill, M. H. de Angelis, and G. S. Barsh Genetics of dark skin in mice Genes & Dev., January 15, 2003; 17(2): 214 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Mitchell, M. L. Weiss, B. M. Mitchell, P. Martin, D. Davis, L. Morales, B. Helwig, M. Beerenstrauch, K. Abou-Easa, T. Hildreth, et al. Matrix Cells from Wharton's Jelly Form Neurons and Glia Stem Cells, January 1, 2003; 21(1): 50 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Coffman, R. C. Strohm, F. D. Oakley, Y. Yamada, D. Przychodzin, and R. E. Boswell Identification of X-Linked Genes Required for Migration and Programmed Cell Death of Drosophila melanogaster Germ Cells Genetics, September 1, 2002; 162(1): 273 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. J. Peters, D. J. Tobin, N. Botchkareva, M. Maurer, and R. Paus Migration of Melanoblasts into the Developing Murine Hair Follicle Is Accompanied by Transient c-Kit Expression J. Histochem. Cytochem., June 1, 2002; 50(6): 751 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hemmi, M. Yoshino, H. Yamazaki, M. Naito, T. Iyoda, Y. Omatsu, S. Shimoyama, J. J. Letterio, T. Nakabayashi, H. Tagaya, et al. Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-{beta}1-dependent cells Int. Immunol., May 1, 2001; 13(5): 695 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. V. BOTCHKAREVA, M. KHLGATIAN, B. J. LONGLEY, V. A. BOTCHKAREV, and B. A. GILCHREST SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit FASEB J, March 1, 2001; 15(3): 645 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fang, R. Steinmetz, D. W. King, P. Zeng, C. Vogelweid, S. Cooper, G. Hangcoc, H. E. Broxmeyer, and O. H. Pescovitz Development of a Transgenic Mouse That Overexpresses a Novel Product of the Growth Hormone-Releasing Hormone Gene Endocrinology, April 1, 2000; 141(4): 1377 - 1383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rawls and S. Johnson Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration Development, January 9, 2000; 127(17): 3715 - 3724. [Abstract] [PDF]
|
|
|
|
|
|
D. Parichy, D. Ransom, B Paw, L. Zon, and S. Johnson An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio Development, January 7, 2000; 127(14): 3031 - 3044. [Abstract] [PDF]
|
|
|
|
 |
|
 K. J. Painter, P. K. Maini, and H. G. Othmer Stripe formation in juvenile Pomacanthus explained by a generalized Turing mechanism with chemotaxis PNAS, May 11, 1999; 96(10): 5549 - 5554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Parichy, J. Rawls, S. Pratt, T. Whitfield, and S. Johnson Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development Development, January 8, 1999; 126(15): 3425 - 3436. [Abstract] [PDF]
|
|
|
|
|
|
L. Chin, G. Merlino, and R. A. DePinho Malignant melanoma: modern black plague and genetic black box Genes & Dev., November 15, 1998; 12(22): 3467 - 3481. [Full Text]
|
|
