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Development, Vol 125, Issue 16 3189-3200, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
R Bernardoni, AA Miller and A Giangrande
Institut de Genetique et Biologie Moleculaire et Cellulaire, IGBMC/CNRS/ULP-BP 163 67404 Illkirch, c.u. de Strasbourg, France.
Glial cells differentiate from the neuroepithelium. In flies, gliogenesis depends on the expression of glial cell deficient/glial cell missing (glide/gcm). The phenotype of glide/gcm loss- and gain-of-function mutations suggested that gliogenesis occurs in cells that, by default, would differentiate into neurons. Here we show that glide/gcm is able to induce cells even from a distinct germ layer, the mesoderm, to activate the glial developmental program, which demonstrates that gliogenesis does not require a ground neural state. These findings challenge the common view on the establishment of cell diversity in the nervous system. Strikingly, ectopic glide/gcm overrides positional information by repressing the endogenous developmental program. These findings also indicate that glial differentiation tightly depends on glide/gcm transcriptional regulation. It is likely that glide/gcm homologs act similarly during vertebrate gliogenesis.
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