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Development, Vol 125, Issue 20 3925-3934, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
C Rodriguez-Esteban, JW Schwabe, JD Pena, DE Rincon-Limas, J Magallon, J Botas and JC Belmonte
Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA.
apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.
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