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Development, Vol 125, Issue 21 4283-4292, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
A Nasevicius, T Hyatt, H Kim, J Guttman, E Walsh, S Sumanas, Y Wang and SC Ekker
Department of Biochemistry and Institute of Human Genetics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
We have used zebrafish as a model system for the study of vertebrate dorsoventral patterning. We isolated a maternally expressed and dorsal organizer localized member of the frizzled family of wnt receptors. Wild-type and dominant, loss-of-function molecules in misexpression studies demonstrate frizzled function is necessary and sufficient for dorsal mesoderm specification. frizzled activity is antagonized by the action of GSK-3, and we show GSK-3 is also required for zebrafish dorsal mesoderm formation. frizzled cooperatively interacts with the maternally encoded zebrafish wnt8 protein in dorsal mesodermal fate determination. This frizzled -mediated wnt pathway for dorsal mesoderm specification provides the first evidence for the requirement of a wnt-like signal in vertebrate axis determination.
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