|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 21 4313-4323, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
A Chedotal, JA Del Rio, M Ruiz, Z He, V Borrell, F de Castro, F Ezan, CS Goodman, M Tessier-Lavigne, C Sotelo and E Soriano
INSERM U106, Hopital de la Salpetriere, France. chedotal@infobiogen.fr.
The semaphorins are the largest family of repulsive axon guidance molecules. Secreted semaphorins bind neuropilin receptors and repel sensory, sympathetic and motor axons. Here we show that CA1, CA3 and dentate gyrus axons from E15-E17 mouse embryo explants are selectively repelled by entorhinal cortex and neocortex. The secreted semaphorins Sema III and Sema IV and their receptors Neuropilin-1 and -2 are expressed in the hippocampal formation during appropriate stages. Sema III and Sema IV strongly repel CA1, CA3 and dentate gyrus axons; entorhinal axons are only repelled by Sema III. An antibody against Neuropilin-1 blocks the repulsive action of Sema III and the entorhinal cortex, but has no effect on Sema IV-induced repulsion. Thus, chemorepulsion plays a role in axon guidance in the hippocampus, secreted semaphorins are likely to be responsible for this action, and the same axons can be repelled by two distinct semaphorins via two different receptors.
This article has been cited by other articles:
|
|
 |
|
  L. M. Ellis The role of neuropilins in cancer Mol. Cancer Ther., May 1, 2006; 5(5): 1099 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. X. Yamada, N. Matsuki, and Y. Ikegaya cAMP Differentially Regulates Axonal and Dendritic Development of Dentate Granule Cells J. Biol. Chem., November 11, 2005; 280(45): 38020 - 38028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Suto, K. Ito, M. Uemura, M. Shimizu, Y. Shinkawa, M. Sanbo, T. Shinoda, M. Tsuboi, S. Takashima, T. Yagi, et al. Plexin-A4 Mediates Axon-Repulsive Activities of Both Secreted and Transmembrane Semaphorins and Plays Roles in Nerve Fiber Guidance J. Neurosci., April 6, 2005; 25(14): 3628 - 3637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, R. A. Bender, K. L. Brunson, J. K. Pomper, D. E. Grigoriadis, W. Wurst, and T. Z. Baram Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus PNAS, November 2, 2004; 101(44): 15782 - 15787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tanno, S. Takenaka, and S. Tsuyama Expression and Function of Slit1{alpha}, a Novel Alternative Splicing Product for Slit1 J. Biochem., November 1, 2004; 136(5): 575 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Wolman, Y. Liu, H. Tawarayama, W. Shoji, and M. C. Halloran Repulsion and Attraction of Axons by Semaphorin3D Are Mediated by Different Neuropilins In Vivo J. Neurosci., September 29, 2004; 24(39): 8428 - 8435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.E. Lallier Semaphorin Profiling of Periodontal Fibroblasts and Osteoblasts Journal of Dental Research, September 1, 2004; 83(9): 677 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Watanabe, R. Toyoda, and H. Nakamura Navigation of trochlear motor axons along the midbrain-hindbrain boundary by neuropilin 2 Development, February 1, 2004; 131(3): 681 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sahay, M. E. Molliver, D. D. Ginty, and A. L. Kolodkin Semaphorin 3F Is Critical for Development of Limbic System Circuitry and Is Required in Neurons for Selective CNS Axon Guidance Events J. Neurosci., July 30, 2003; 23(17): 6671 - 6680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Legg and T. P. O'Connor Gradients and Growth Cone Guidance of Grasshopper Neurons J. Histochem. Cytochem., April 1, 2003; 51(4): 445 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Spassky, F. de Castro, B. Le Bras, K. Heydon, F. Queraud-LeSaux, E. Bloch-Gallego, A. Chedotal, B. Zalc, and J.-L. Thomas Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1 J. Neurosci., July 15, 2002; 22(14): 5992 - 6004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Nguyen-Ba-Charvet, A. S. Plump, M. Tessier-Lavigne, and A. Chedotal Slit1 and Slit2 Proteins Control the Development of the Lateral Olfactory Tract J. Neurosci., July 1, 2002; 22(13): 5473 - 5480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Zanata, I. Hovatta, B. Rohm, and A. W. Puschel Antagonistic Effects of Rnd1 and RhoD GTPases Regulate Receptor Activity in Semaphorin 3A-Induced Cytoskeletal Collapse J. Neurosci., January 15, 2002; 22(2): 471 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Li and T. G. Rossman Genes Upregulated in Lead-Resistant Glioma Cells Reveal Possible Targets for Lead-Induced Developmental Neurotoxicity Toxicol. Sci., November 1, 2001; 64(1): 90 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Forster, S. Zhao, and M. Frotscher Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus Development, August 1, 2001; 128(15): 3029 - 3039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. N. Ba-Charvet, K. Brose, L. Ma, K. H. Wang, V. Marillat, C. Sotelo, M. Tessier-Lavigne, and A. Chedotal Diversity and Specificity of Actions of Slit2 Proteolytic Fragments in Axon Guidance J. Neurosci., June 15, 2001; 21(12): 4281 - 4289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Tashiro, M Miyahara, R Shirasaki, M Okabe, C. Heizmann, and F Murakami Local nonpermissive and oriented permissive cues guide vestibular axons to the cerebellum Development, January 3, 2001; 128(6): 973 - 981. [Abstract] [PDF]
|
|
|
|
|
|
M. Barallobre, J. Del Rio, S Alcantara, V Borrell, F Aguado, M Ruiz, M. Carmona, M Martin, M Fabre, R Yuste, et al. Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice Development, January 11, 2000; 127(22): 4797 - 4810. [Abstract] [PDF]
|
|
|
|
 |
|
 E. A. Grove and S. Tole Patterning Events and Specification Signals in the Developing Hippocampus Cereb Cortex, September 1, 1999; 9(6): 551 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. d. Castro, L. Hu, H. Drabkin, C. Sotelo, and A. Chedotal Chemoattraction and Chemorepulsion of Olfactory Bulb Axons by Different Secreted Semaphorins J. Neurosci., June 1, 1999; 19(11): 4428 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Borrell, J. A. Del Rio, S. Alcantara, M. Derer, A. Martinez, G. D'Arcangelo, K. Nakajima, K. Mikoshiba, P. Derer, T. Curran, et al. Reelin Regulates the Development and Synaptogenesis of the Layer-Specific Entorhino-Hippocampal Connections J. Neurosci., February 15, 1999; 19(4): 1345 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Polleux, R. J. Giger, D. D. Ginty, A. L. Kolodkin, and A. Ghosh Patterning of Cortical Efferent Projections by Semaphorin-Neuropilin Interactions Science, December 4, 1998; 282(5395): 1904 - 1906. [Abstract] [Full Text]
|
|
|
|
|
|
Z. Gluzman-Poltorak, T. Cohen, Y. Herzog, and G. Neufeld Neuropilin-2 and Neuropilin-1 Are Receptors for the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF) and of Placenta Growth Factor-2, but Only Neuropilin-2 Functions as a Receptor for the 145-Amino Acid Form of VEGF J. Biol. Chem., June 9, 2000; 275(24): 18040 - 18045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jossin and A. M. Goffinet Reelin Does Not Directly Influence Axonal Growth J. Neurosci., December 1, 2001; 21(23): RC183 - RC183. [Abstract] [Full Text] [PDF]
|
|
