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Development, Vol 125, Issue 22 4553-4564, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
N McGinnis, E Ragnhildstveit, A Veraksa and W McGinnis
Department of Biology, University of California, San Diego, La Jolla, CA, 92093, USA.
We have characterized a protein isoform (CncB) from the Drosophila cap 'n' collar locus that selectively represses cis-regulatory elements that are activated by the Hox protein Deformed. Of the three Cnc protein isoforms, CncB is expressed in a localized pattern in mandibular and labral cells of the head during mid-stages of embryogenesis. When CncB protein is absent or reduced, mandibular cells are homeotically transformed toward maxillary identities. This transformation is associated with persistent Deformed expression in anterior mandibular cells, since the Deformed autoactivation circuit is normally antagonized by CncB function in these cells. Heat-shock-induced ectopic expression of CncB in mid-stages of embryogenesis is sufficient to attenuate the activity of Dfd response elements in maxillary epidermal cells, but appears to have no effect in trunk epidermal cells on either the function or the response elements of other Hox proteins. CncB provides a mechanism to modulate the specificity of Hox morphogenetic outcomes, which results in an increase in the segmental diversity in the Drosophila head.
This article has been cited by other articles:
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  E. Tour, C. T. Hittinger, and W. McGinnis Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax Development, December 1, 2005; 132(23): 5271 - 5281. [Abstract] [Full Text] [PDF]
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S Alper and C Kenyon REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity Development, January 5, 2001; 128(10): 1793 - 1804. [Abstract] [PDF]
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H Zhang and S. Emmons The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression Development, January 3, 2001; 128(5): 767 - 777. [Abstract] [PDF]
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 S. Brown, M. DeCamillis, K. Gonzalez-Charneco, M. Denell, R. Beeman, W. Nie, and R. Denell Special Feature: Implications of the Tribolium Deformed mutant phenotype for the evolution of Hox gene function PNAS, April 25, 2000; 97(9): 4510 - 4514. [Abstract] [Full Text] [PDF]
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A Veraksa, N McGinnis, X Li, J Mohler, and W McGinnis Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head Development, January 9, 2000; 127(18): 4023 - 4037. [Abstract] [PDF]
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E. Wiellette, K. Harding, K. Mace, M. Ronshaugen, F. Wang, and W McGinnis spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk Development, January 12, 1999; 126(23): 5373 - 5385. [Abstract] [PDF]
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M Crozatier, D Valle, L Dubois, S Ibnsouda, and A Vincent Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment Development, January 10, 1999; 126(19): 4385 - 4394. [Abstract] [PDF]
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Q Ch'ng and C Kenyon egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function Development, January 8, 1999; 126(15): 3303 - 3312. [Abstract] [PDF]
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