spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takuma, N.
Right arrow Articles by Mahon, K. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takuma, N.
Right arrow Articles by Mahon, K. A.

Development, Vol 125, Issue 23 4835-4840, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Formation of Rathke's pouch requires dual induction from the diencephalon

N Takuma, HZ Sheng, Y Furuta, JM Ward, K Sharma, BL Hogan, SL Pfaff, H Westphal, S Kimura and KA Mahon
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development and Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Targeted disruption of the homeobox gene T/ebp (Nkx2.1, Ttf1, Titf1) in mice results in ablation of the pituitary. Paradoxically, while T/ebp is expressed in the ventral diencephalon during forebrain formation, it is not expressed in Rathke's pouch or in the pituitary gland at any time of embryogenesis. Examination of pituitary development in the T/ebp homozygous null mutant embryos revealed that a pouch rudiment is initially formed but is eliminated by programmed cell death before formation of a definitive pouch. In the diencephalon of the mutant, Bmp4 expression is maintained, whereas Fgf8 expression is not detectable. These data and additional genetic and molecular observations suggest that Rathke's pouch develops in a two-step process that requires at least two sequential inductive signals from the diencephalon. First, BMP4 is required for induction and formation of the pouch rudiment, a role confirmed by analysis of Bmp4 homozygous null mutant embryos. Second, FGF8 is necessary for activation of the key regulatory gene Lhx3 and subsequent development of the pouch rudiment into a definitive pouch. This study provides firm molecular genetic evidence that morphogenesis of the pituitary primordium is induced in vivo by signals from the adjacent diencephalon.


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
A. T. McElvaine, A. I. Korytko, S. M. Kilen, L. Cuttler, and K. E. Mayo
Pituitary-Specific Expression and Pit-1 Regulation of the Rat Growth Hormone-Releasing Hormone Receptor Gene
Mol. Endocrinol., August 1, 2007; 21(8): 1969 - 1983.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld
Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks
Physiol Rev, July 1, 2007; 87(3): 933 - 963.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Mastronardi, G. G. Smiley, J. Raber, T. Kusakabe, A. Kawaguchi, V. Matagne, A. Dietzel, S. Heger, A. E. Mungenast, R. Cabrera, et al.
Deletion of the Ttf1 Gene in Differentiated Neurons Disrupts Female Reproduction without Impairing Basal Ganglia Function
J. Neurosci., December 20, 2006; 26(51): 13167 - 13179.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Zhu, J. Zhang, J. Tollkuhn, R. Ohsawa, E. H. Bresnick, F. Guillemot, R. Kageyama, and M. G. Rosenfeld
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis
Genes & Dev., October 1, 2006; 20(19): 2739 - 2753.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
V. Hartenstein
The neuroendocrine system of invertebrates: a developmental and evolutionary perspective.
J. Endocrinol., September 1, 2006; 190(3): 555 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Granger, C. Bleux, M.-L. Kottler, S. J. Rhodes, R. Counis, and J.-N. Laverriere
The LIM-Homeodomain Proteins Isl-1 and Lhx3 Act with Steroidogenic Factor 1 to Enhance Gonadotrope-Specific Activity of the Gonadotropin-Releasing Hormone Receptor Gene Promoter
Mol. Endocrinol., September 1, 2006; 20(9): 2093 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. M. Moya, G. Perez de Nanclares, L. Castano, N. Potau, J. R. Bilbao, A. Carrascosa, M. Bargada, R. Coya, P. Martul, E. Vicens-Calvet, et al.
Functional Study of a Novel Single Deletion in the TITF1/NKX2.1 Homeobox Gene That Produces Congenital Hypothyroidism and Benign Chorea But Not Pulmonary Distress
J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1832 - 1841.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Ribes, Z. Wang, P. Dolle, and K. Niederreither
Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling
Development, January 15, 2006; 133(2): 351 - 361.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M-O Faure, L Nicol, S Fabre, J Fontaine, N Mohoric, A McNeilly, and C Taragnat
BMP-4 inhibits follicle-stimulating hormone secretion in ewe pituitary
J. Endocrinol., July 1, 2005; 186(1): 109 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. A. Charles, H. Suh, T. A. Hjalt, J. Drouin, S. A. Camper, and P. J. Gage
PITX Genes Are Required for Cell Survival and Lhx3 Activation
Mol. Endocrinol., July 1, 2005; 19(7): 1893 - 1903.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Nudi, J.-F. Ouimette, and J. Drouin
Bone Morphogenic Protein (Smad)-Mediated Repression of Proopiomelanocortin Transcription by Interference with Pitx/Tpit Activity
Mol. Endocrinol., May 1, 2005; 19(5): 1329 - 1342.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Dutta, J.-E. Dietrich, G. Aspock, R. D. Burdine, A. Schier, M. Westerfield, and Z. M. Varga
pitx3 defines an equivalence domain for lens and anterior pituitary placode
Development, April 1, 2005; 132(7): 1579 - 1590.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. D. Ward, L. T. Raetzman, H. Suh, B. M. Stone, I. O. Nasonkin, and S. A. Camper
Role of PROP1 in Pituitary Gland Growth
Mol. Endocrinol., March 1, 2005; 19(3): 698 - 710.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
P. E Mullis
Genetic control of growth
Eur. J. Endocrinol., January 1, 2005; 152(1): 11 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. De Felice and R. Di Lauro
Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms
Endocr. Rev., October 1, 2004; 25(5): 722 - 746.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Herzog, C. Sonntag, S. von der Hardt, H. H. Roehl, Z. M. Varga, and M. Hammerschmidt
Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis
Development, August 1, 2004; 131(15): 3681 - 3692.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
W. Herzog, C. Sonntag, B. Walderich, J. Odenthal, H.-M. Maischein, and M. Hammerschmidt
Genetic Analysis of Adenohypophysis Formation in Zebrafish
Mol. Endocrinol., May 1, 2004; 18(5): 1185 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. P. Gupta, M. Wang, and P. W. Sternberg
The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development
Development, June 15, 2003; 130(12): 2589 - 2601.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A.-M. Pulichino, S. Vallette-Kasic, J. P.-Y. Tsai, C. Couture, Y. Gauthier, and J. Drouin
Tpit determines alternate fates during pituitary cell differentiation
Genes & Dev., March 15, 2003; 17(6): 738 - 747.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. T. Raetzman, R. Ward, and S. A. Camper
Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia
Development, March 11, 2003; 129(18): 4229 - 4239.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. E. Olson and M. G. Rosenfeld
Perspective: Genetic and Genomic Approaches in Elucidating Mechanisms of Pituitary Development
Endocrinology, June 1, 2002; 143(6): 2007 - 2011.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
G. J. Breedveld, J. W.F. van Dongen, C. Danesino, A. Guala, A. K. Percy, L. S. Dure, P. Harper, L. P. Lazarou, H. van der Linde, M. Joosse, et al.
Mutations in TITF-1 are associated with benign hereditary chorea
Hum. Mol. Genet., April 15, 2002; 11(8): 971 - 979.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. M. Scully and M. G. Rosenfeld
Pituitary Development: Regulatory Codes in Mammalian Organogenesis
Science, March 22, 2002; 295(5563): 2231 - 2235.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. M. Anderson, A. R. Lawrence, R. W. Stottmann, D. Bachiller, and J. Klingensmith
Chordin and noggin promote organizing centers of forebrain development in the mouse
Development, January 11, 2002; 129(21): 4975 - 4987.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. Marin, J. Baker, L. Puelles, and J. L. R. Rubenstein
Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections
Development, January 2, 2002; 129(3): 761 - 773.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Niimi, K. Nagashima, J. M. Ward, P. Minoo, D. B. Zimonjic, N. C. Popescu, and S. Kimura
claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing
Mol. Cell. Biol., November 1, 2001; 21(21): 7380 - 7390.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Niimi, C. L. Keck-Waggoner, N. C. Popescu, Y. Zhou, R. C. Levitt, and S. Kimura
UGRP1, a Uteroglobin/Clara Cell Secretory Protein-Related Protein, Is a Novel Lung-Enriched Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor
Mol. Endocrinol., November 1, 2001; 15(11): 2021 - 2036.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
B. Andersen and M. G. Rosenfeld
POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease
Endocr. Rev., February 1, 2001; 22(1): 2 - 35.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
M Treier, S O'Connell, A Gleiberman, J Price, D. Szeto, R Burgess, P. Chuang, A. McMahon, and M. Rosenfeld
Hedgehog signaling is required for pituitary gland development
Development, January 2, 2001; 128(3): 377 - 386.
[Abstract] [PDF]

Home page
 DevelopmentHome page
L Gunhaga, T. Jessell, and T Edlund
Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo
Development, January 8, 2000; 127(15): 3283 - 3293.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H. Park, C Bai, K. Platt, M. Matise, A Beeghly, C. Hui, M Nakashima, and A. Joyner
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
Development, January 4, 2000; 127(8): 1593 - 1605.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Pernasetti, S. P. A. Toledo, V. V. Vasilyev, C. Y. Hayashida, J. D. Cogan, C. Ferrari, D. M. Lourenço, and P. L. Mellon
Impaired Adrenocorticotropin-Adrenal Axis in Combined Pituitary Hormone Deficiency Caused by a Two-Base Pair Deletion (301-302delAG) in the Prophet of Pit-1 Gene
J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 390 - 397.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Kioussi, S. O'Connell, L. St-Onge, M. Treier, A. S. Gleiberman, P. Gruss, and M. G. Rosenfeld
Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
PNAS, December 7, 1999; 96(25): 14378 - 14382.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. W. Sloop, B. C. Meier, J. L. Bridwell, G. E. Parker, A. M. Schiller, and S. J. Rhodes
Differential Activation of Pituitary Hormone Genes by Human Lhx3 Isoforms with Distinct DNA Binding Properties
Mol. Endocrinol., December 1, 1999; 13(12): 2212 - 2225.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
D. P. Szeto, C. Rodriguez-Esteban, A. K. Ryan, S. M. O'Connell, F. Liu, C. Kioussi, A. S. Gleiberman, J. C. Izpisúa-Belmonte, and M. G. Rosenfeld
Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development
Genes & Dev., February 15, 1999; 13(4): 484 - 494.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
L Sussel, O Marin, S Kimura, and J. Rubenstein
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
Development, January 8, 1999; 126(15): 3359 - 3370.
[Abstract] [PDF]


© The Company of Biologists Ltd 1998