|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 23 4851-4861, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
B Saulier-Le Drean, A Nasiadka, J Dong and HM Krause
Banting and Best Department of Medical Research, Charles H. Best Institute, University of Toronto, Toronto, Ontario, Canada, M5G 1L6.
Although many of the genes that pattern the segmented body plan of the Drosophila embryo are known, there remains much to learn in terms of how these genes and their products interact with one another. Like many of these gene products, the protein encoded by the pair-rule gene odd-skipped (Odd) is a DNA-binding transcription factor. Genetic experiments have suggested several candidate target genes for Odd, all of which appear to be negatively regulated. Here we use pulses of ectopic Odd expression to test the response of these and other segmentation genes. The results are complex, indicating that Odd is capable of repressing some genes wherever and whenever Odd is expressed, while the ability to repress others is temporally or spatially restricted. Moreover, one target gene, fushi tarazu, is both repressed and activated by Odd, the outcome depending upon the stage of development. These results indicate that the activity of Odd is highly dependent upon the presence of cofactors and/or overriding inhibitors. Based on these results, and the segmental phenotypes generated by ectopic Odd, we suggest a number of new roles for Odd in the patterning of embryonic segments. These include gap-, pair-rule- and segment polarity-type functions.
This article has been cited by other articles:
|
|
 |
|
  S. Vincent, N. Perrimon, and J. D. Axelrod Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning Development, August 15, 2008; 135(16): 2767 - 2775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Choe, S. C. Miller, and S. J. Brown A pair-rule gene circuit defines segments sequentially in the short-germ insect Tribolium castaneum PNAS, April 25, 2006; 103(17): 6560 - 6564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Goldstein, O. Cook, T. Dinur, A. Pisante, U. C. Karandikar, A. Bidwai, and Z. Paroush An eh1-Like Motif in Odd-skipped Mediates Recruitment of Groucho and Repression In Vivo Mol. Cell. Biol., December 15, 2005; 25(24): 10711 - 10720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lan, C. E. Ovitt, E.-S. Cho, K. M. Maltby, Q. Wang, and R. Jiang Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis Development, July 1, 2004; 131(13): 3207 - 3216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kobayashi, M. Fujioka, E. N. Tolkunova, D. Deka, M. Abu-Shaar, R. S. Mann, and J. B. Jaynes Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila Development, February 15, 2003; 130(4): 741 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hughes and H. Krause Establishment and maintenance of parasegmental compartments Development, January 4, 2001; 128(7): 1109 - 1118. [Abstract] [PDF]
|
|
|
|
|
|
A Nasiadka, A Grill, and H. Krause Mechanisms regulating target gene selection by the homeodomain-containing protein Fushi tarazu Development, January 7, 2000; 127(13): 2965 - 2976. [Abstract] [PDF]
|
|
|
|
|
|
M. Mannervik and M. Levine The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo PNAS, June 8, 1999; 96(12): 6797 - 6801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Nasiadka and H. Krause Kinetic analysis of segmentation gene interactions in Drosophila embryos Development, January 4, 1999; 126(7): 1515 - 1526. [Abstract] [PDF]
|
|
