|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 12 2631-2642, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
TG Clark, SJ Conway, IC Scott, PA Labosky, G Winnier, J Bundy, BL Hogan and DS Greenspan
Department of Pathology and Laboratory Medicine and Cardiovascular Research Center, University of Wisconsin, Madison, WI 53706, USA.
Mammalian Tolloid-like 1 (mTLL-1) is an astacin-like metalloprotease, highly similar in domain structure to the morphogenetically important proteases bone morphogenetic protein-1 (BMP-1) and Drosophila Tolloid. To investigate possible roles for mTLL-1 in mammalian development, we have used gene targeting in ES cells to produce mice with a disrupted allele for the corresponding gene, Tll1. Homozygous mutants were embryonic lethal, with death at mid-gestation from cardiac failure and a unique constellation of developmental defects that were apparently confined solely to the heart. Constant features were incomplete formation of the muscular interventricular septum and an abnormal and novel positioning of the heart and aorta. Consistent with roles in cardiac development, Tll1 expression was specific to precardiac tissue and endocardium in 7.5 and 8.5 days p.c. embryos, respectively. Tll1 expression was also high in the developing interventricular septum, where expression of the BMP-1 gene, Bmp1, was not observed. Cardiac structures that were not affected in Tll1-/- embryos either showed no Tll1 expression (atrio-ventricular cushions) or showed overlapping expression of Tll1 and Bmp1 (aortico-pulmonary septum), suggesting that products of the Bmp1 gene may be capable of functionally substituting for mTLL-1 at sites in which they are co-expressed. Together, the various data show that mTLL-1 plays multiple roles in formation of the mammalian heart and is essential for formation of the interventricular septum.
This article has been cited by other articles:
|
|
 |
|
  G. Ge, C. A. Fernandez, M. A. Moses, and D. S. Greenspan Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor PNAS, June 12, 2007; 104(24): 10010 - 10015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ge, Y. Zhang, B. M. Steiglitz, and D. S. Greenspan Mammalian Tolloid-like 1 Binds Procollagen C-proteinase Enhancer Protein 1 and Differs from Bone Morphogenetic Protein 1 in the Functional Roles of Homologous Protein Domains J. Biol. Chem., April 21, 2006; 281(16): 10786 - 10798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Moali, B. Font, F. Ruggiero, D. Eichenberger, P. Rousselle, V. Francois, A. Oldberg, L. Bruckner-Tuderman, and D. J. S. Hulmes Substrate-specific Modulation of a Multisubstrate Proteinase: C-TERMINAL PROCESSING OF FIBRILLAR PROCOLLAGENS IS THE ONLY BMP-1-DEPENDENT ACTIVITY TO BE ENHANCED BY PCPE-1 J. Biol. Chem., June 24, 2005; 280(25): 24188 - 24194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Serpe, A. Ralston, S. S. Blair, and M. B. O'Connor Matching catalytic activity to developmental function: Tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing Development, June 1, 2005; 132(11): 2645 - 2656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xie and S. Fisher Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms Development, January 15, 2005; 132(2): 383 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Takeuchi, M. Ohgi, K. Koshiba-Takeuchi, H. Shiratori, I. Sakaki, K. Ogura, Y. Saijoh, and T. Ogura Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis Development, December 15, 2003; 130(24): 5953 - 5964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. N. Pappano, B. M. Steiglitz, I. C. Scott, D. R. Keene, and D. S. Greenspan Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases Mol. Cell. Biol., July 1, 2003; 23(13): 4428 - 4438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Delot, M. E. Bahamonde, M. Zhao, and K. M. Lyons BMP signaling is required for septation of the outflow tract of the mammalian heart Development, January 1, 2003; 130(1): 209 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sakata, C. N. Kamei, H. Nakagami, R. Bronson, J. K. Liao, and M. T. Chin Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2 PNAS, December 10, 2002; 99(25): 16197 - 16202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-B. Yang, C. K. D. Ng, S. M. Wasserman, S. D. Colman, S. Shenoy, F. Mehraban, L. G. Komuves, J. E. Tomlinson, and J. N. Topper Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium J. Biol. Chem., November 22, 2002; 277(48): 46364 - 46373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rattenholl, W. N. Pappano, M. Koch, D. R. Keene, K. E. Kadler, T. Sasaki, R. Timpl, R. E. Burgeson, D. S. Greenspan, and L. Bruckner-Tuderman Proteinases of the Bone Morphogenetic Protein-1 Family Convert Procollagen VII to Mature Anchoring Fibril Collagen J. Biol. Chem., July 12, 2002; 277(29): 26372 - 26378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Unsold, W. N. Pappano, Y. Imamura, B. M. Steiglitz, and D. S. Greenspan Biosynthetic Processing of the Pro-alpha 1(V)2Pro-alpha 2(V) Collagen Heterotrimer by Bone Morphogenetic Protein-1 and Furin-like Proprotein Convertases J. Biol. Chem., February 8, 2002; 277(7): 5596 - 5602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Scott, Y. Imamura, W. N. Pappano, J. M. Troedel, A. D. Recklies, P. J. Roughley, and D. S. Greenspan Bone Morphogenetic Protein-1 Processes Probiglycan J. Biol. Chem., September 22, 2000; 275(39): 30504 - 30511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Uzel, I. C. Scott, H. Babakhanlou-Chase, A. H. Palamakumbura, W. N. Pappano, H.-H. Hong, D. S. Greenspan, and P. C. Trackman Multiple Bone Morphogenetic Protein 1-related Mammalian Metalloproteinases Process Pro-lysyl Oxidase at the Correct Physiological Site and Control Lysyl Oxidase Activation in Mouse Embryo Fibroblast Cultures J. Biol. Chem., June 15, 2001; 276(25): 22537 - 22543. [Abstract] [Full Text] [PDF]
|
|
