spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guo, K.
Right arrow Articles by Gross, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guo, K.
Right arrow Articles by Gross, J. D.

Development, Vol 126, Issue 12 2813-2822, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

A myb-related protein required for culmination in Dictyostelium

K Guo, C Anjard, A Harwood, HJ Kim, PC Newell and JD Gross
Dept of Biochemistry University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

The avian retroviral v-myb gene and its cellular homologues throughout the animal and plant kingdoms contain a conserved DNA binding domain. We have isolated an insertional mutant of Dictyostelium unable to switch from slug migration to fruiting body formation i.e. unable to culminate. The gene that is disrupted, mybC, codes for a protein with a myb-like domain that is recognized by an antibody against the v-myb repeat domain. During development of myb+ cells, mybC is expressed only in prestalk cells. When developed together with wild-type cells mybC- cells are able to form both spores and stalk cells very efficiently. Their developmental defect is also bypassed by overexpressing cAMP-dependent protein kinase. However even when their defect is bypassed, mybC null slugs and culminates produce little if any of the intercellular signalling peptides SDF-1 and SDF-2 that are believed to be released by prestalk cells at culmination. We propose that the mybC gene product is required for an intercellular signaling process controlling maturation of stalk cells and spores and that SDF-1 and/or SDF-2 may be implicated in this process.


This article has been cited by other articles:


Home page
 DevelopmentHome page
M. Fukuzawa, N. V. Zhukovskaya, Y. Yamada, T. Araki, and J. G. Williams
Regulation of Dictyostelium prestalk-specific gene expression by a SHAQKY family MYB transcription factor
Development, May 1, 2006; 133(9): 1715 - 1724.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Iranfar, D. Fuller, R. Sasik, T. Hwa, M. Laub, and W. F. Loomis
Expression Patterns of Cell-type-specific Genes in Dictyostelium
Mol. Biol. Cell, September 1, 2001; 12(9): 2590 - 2600.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1999