spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dahmane, N.
Right arrow Articles by Ruiz-i-Altaba, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dahmane, N.
Right arrow Articles by Ruiz-i-Altaba, A.

Development, Vol 126, Issue 14 3089-3100, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Sonic hedgehog regulates the growth and patterning of the cerebellum

N Dahmane and A Ruiz-i-Altaba
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA. ria@saturn.med.nyu.edu

The molecular bases of brain development and CNS malignancies remain poorly understood. Here we show that Sonic hedgehog (Shh) signaling controls the development of the cerebellum at multiple levels. SHH is produced by Purkinje neurons, it is required for the proliferation of granule neuron precursors and it induces the differentiation of Bergmann glia. Blocking SHH function in vivo results in deficient granule neuron and Bergmann glia differentiation as well as in abnormal Purkinje neuron development. Thus, our findings provide a molecular model for the growth and patterning of the cerebellum by SHH through the coordination of the development of cortical cerebellar cell types. In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum.


This article has been cited by other articles:


Home page
 DevelopmentHome page
S. R. Parathath, L. A. Mainwaring, A. Fernandez-L, D. O. Campbell, and A. M. Kenney
Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors
Development, October 1, 2008; 135(19): 3291 - 3300.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Komada, H. Saitsu, M. Kinboshi, T. Miura, K. Shiota, and M. Ishibashi
Hedgehog signaling is involved in development of the neocortex
Development, August 15, 2008; 135(16): 2717 - 2727.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Blaess, D. Stephen, and A. L. Joyner
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling
Development, June 15, 2008; 135(12): 2093 - 2103.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
X. Fan and C. G. Eberhart
Medulloblastoma Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2821 - 2827.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. B. Dirks
Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer
J. Clin. Oncol., June 10, 2008; 26(17): 2916 - 2924.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. A. Hatton, E. H. Villavicencio, K. D. Tsuchiya, J. I. Pritchard, S. Ditzler, B. Pullar, S. Hansen, S. E. Knoblaugh, D. Lee, C. G. Eberhart, et al.
The Smo/Smo Model: Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread
Cancer Res., March 15, 2008; 68(6): 1768 - 1776.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. R. Grimmer and W. A. Weiss
BMPs oppose Math1 in cerebellar development and in medulloblastoma
Genes & Dev., March 15, 2008; 22(6): 693 - 699.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
K. J. Briggs, I. M. Corcoran-Schwartz, W. Zhang, T. Harcke, W. L. Devereux, S. B. Baylin, C. G. Eberhart, and D. N. Watkins
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma
Genes & Dev., March 15, 2008; 22(6): 770 - 785.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A-r. Jung, T. W. Kim, I. J. Rhyu, H. Kim, Y. D. Lee, S. Vinsant, R. W. Oppenheim, and W. Sun
Misplacement of Purkinje Cells during Postnatal Development in Bax Knock-Out Mice: A Novel Role for Programmed Cell Death in the Nervous System?
J. Neurosci., March 12, 2008; 28(11): 2941 - 2948.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
R. V. Sillitoe and M. W. Vogel
Desire, Disease, and the Origins of the Dopaminergic System
Schizophr Bull, March 1, 2008; 34(2): 212 - 219.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. Hambardzumyan, O. J. Becher, M. K. Rosenblum, P. P. Pandolfi, K. Manova-Todorova, and E. C. Holland
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
Genes & Dev., February 15, 2008; 22(4): 436 - 448.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
B. Carletti and F. Rossi
Neurogenesis in the Cerebellum
Neuroscientist, February 1, 2008; 14(1): 91 - 100.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
F. Balordi and G. Fishell
Mosaic Removal of Hedgehog Signaling in the Adult SVZ Reveals That the Residual Wild-Type Stem Cells Have a Limited Capacity for Self-Renewal
J. Neurosci., December 26, 2007; 27(52): 14248 - 14259.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Alvarez-Rodriguez, M. Barzi, J. Berenguer, and S. Pons
Bone Morphogenetic Protein 2 Opposes Shh-mediated Proliferation in Cerebellar Granule Cells through a TIEG-1-based Regulation of Nmyc
J. Biol. Chem., December 21, 2007; 282(51): 37170 - 37180.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J.-S. Yun, J. M. Rust, T. Ishimaru, and E. Diaz
A Novel Role of the Mad Family Member Mad3 in Cerebellar Granule Neuron Precursor Proliferation
Mol. Cell. Biol., December 1, 2007; 27(23): 8178 - 8189.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
E. E. Bar, A. Chaudhry, A. Lin, X. Fan, K. Schreck, W. Matsui, S. Piccirillo, A. L. Vescovi, F. DiMeco, A. Olivi, et al.
Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma
Stem Cells, October 1, 2007; 25(10): 2524 - 2533.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. V. Chizhikov, J. Davenport, Q. Zhang, E. K. Shih, O. A. Cabello, J. L. Fuchs, B. K. Yoder, and K. J. Millen
Cilia Proteins Control Cerebellar Morphogenesis by Promoting Expansion of the Granule Progenitor Pool
J. Neurosci., September 5, 2007; 27(36): 9780 - 9789.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
E. Salsano, L. Croci, E. Maderna, L. Lupo, B. Pollo, M. T. Giordana, G. G. Consalez, and G. Finocchiaro
Expression of the neurogenic basic helix-loop-helix transcription factor NEUROG1 identifies a subgroup of medulloblastomas not expressing ATOH1
Neuro-oncol, July 1, 2007; 9(3): 298 - 307.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Farioli-Vecchioli, M. Tanori, L. Micheli, M. Mancuso, L. Leonardi, A. Saran, M. T. Ciotti, E. Ferretti, A. Gulino, S. Pazzaglia, et al.
Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3
FASEB J, July 1, 2007; 21(9): 2215 - 2225.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Deng, A. Hirschberg, T. Worzfeld, J. Y. Penachioni, A. Korostylev, J. M. Swiercz, P. Vodrazka, O. Mauti, E. T. Stoeckli, L. Tamagnone, et al.
Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo
J. Neurosci., June 6, 2007; 27(23): 6333 - 6347.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. D. McCall, C. A. Pedone, and D. W. Fults
Apoptosis Suppression by Somatic Cell Transfer of Bcl-2 Promotes Sonic Hedgehog-Dependent Medulloblastoma Formation in Mice
Cancer Res., June 1, 2007; 67(11): 5179 - 5185.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Balordi and G. Fishell
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons
J. Neurosci., May 30, 2007; 27(22): 5936 - 5947.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Vaillant, O. Michos, S. Orolicki, F. Brellier, S. Taieb, E. Moreno, H. Te, R. Zeller, and D. Monard
Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development
Development, May 1, 2007; 134(9): 1745 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. H. Friedel, G. Kerjan, H. Rayburn, U. Schuller, C. Sotelo, M. Tessier-Lavigne, and A. Chedotal
Plexin-B2 Controls the Development of Cerebellar Granule Cells
J. Neurosci., April 4, 2007; 27(14): 3921 - 3932.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Stecca, C. Mas, V. Clement, M. Zbinden, R. Correa, V. Piguet, F. Beermann, and A. Ruiz i Altaba
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
PNAS, April 3, 2007; 104(14): 5895 - 5900.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. A. Alcaraz, D. A. Gold, E. Raponi, P. M. Gent, D. Concepcion, and B. A. Hamilton
Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation
PNAS, December 19, 2006; 103(51): 19424 - 19429.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. A. Hatton, P. S. Knoepfler, A. M. Kenney, D. H. Rowitch, I. M. de Alboran, J. M. Olson, and R. N. Eisenman
N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth.
Cancer Res., September 1, 2006; 66(17): 8655 - 8661.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. D. Corrales, S. Blaess, E. M. Mahoney, and A. L. Joyner
The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation
Development, May 1, 2006; 133(9): 1811 - 1821.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. R. Browd, A. M. Kenney, O. N. Gottfried, J. W. Yoon, D. Walterhouse, C. A. Pedone, and D. W. Fults
N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog-Induced Medulloblastoma.
Cancer Res., March 1, 2006; 66(5): 2666 - 2672.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Cayuso, F. Ulloa, B. Cox, J. Briscoe, and E. Marti
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity
Development, February 1, 2006; 133(3): 517 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. J. Roper, L. L. Baxter, N. G. Saran, D. K. Klinedinst, P. A. Beachy, and R. H. Reeves
Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice
PNAS, January 31, 2006; 103(5): 1452 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Mills, A. Niewmierzycka, A. Oloumi, B. Rico, R. St-Arnaud, I. R. Mackenzie, N. M. Mawji, J. Wilson, L. F. Reichardt, and S. Dedhar
Critical Role of Integrin-Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development
J. Neurosci., January 18, 2006; 26(3): 830 - 840.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. Nagao, N. Togawa, K. Fujii, H. Uchikawa, Y. Kohno, M. Yamada, and T. Miyashita
Detecting tissue-specific alternative splicing and disease-associated aberrant splicing of the PTCH gene with exon junction microarrays
Hum. Mol. Genet., November 15, 2005; 14(22): 3379 - 3388.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Choi, P. R. Borghesani, J. A. Chan, and R. A. Segal
Migration from a Mitogenic Niche Promotes Cell-Cycle Exit
J. Neurosci., November 9, 2005; 25(45): 10437 - 10445.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. M. Louie and J. G. Gleeson
Genetic basis of Joubert syndrome and related disorders of cerebellar development
Hum. Mol. Genet., October 15, 2005; 14(suppl_2): R235 - R242.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Klein, S. J. B. Butt, R. P. Machold, J. E. Johnson, and G. Fishell
Cerebellum- and forebrain-derived stem cells possess intrinsic regional character
Development, October 15, 2005; 132(20): 4497 - 4508.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Argenti, R. Gallo, L. Di Marcotullio, E. Ferretti, M. Napolitano, S. Canterini, E. De Smaele, A. Greco, M. T. Fiorenza, M. Maroder, et al.
Hedgehog Antagonist RENKCTD11 Regulates Proliferation and Apoptosis of Developing Granule Cell Progenitors
J. Neurosci., September 7, 2005; 25(36): 8338 - 8346.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. L. Close, B. Gumuscu, and T. A. Reh
Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF{beta} signaling
Development, July 1, 2005; 132(13): 3015 - 3026.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. W.M. Bruggeman, M. E. Valk-Lingbeek, P. P.M. van der Stoop, J. J.L. Jacobs, K. Kieboom, E. Tanger, D. Hulsman, C. Leung, Y. Arsenijevic, S. Marino, et al.
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
Genes & Dev., June 15, 2005; 19(12): 1438 - 1443.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Palma, D. A. Lim, N. Dahmane, P. Sanchez, T. C. Brionne, C. D. Herzberg, Y. Gitton, A. Carleton, A. Alvarez-Buylla, and A. R. i Altaba
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
Development, January 15, 2005; 132(2): 335 - 344.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Canudas, V. Di Giorgi-Gerevini, L. Iacovelli, G. Nano, M. D'Onofrio, A. Arcella, F. Giangaspero, C. Busceti, L. Ricci-Vitiani, G. Battaglia, et al.
PHCCC, a Specific Enhancer of Type 4 Metabotropic Glutamate Receptors, Reduces Proliferation and Promotes Differentiation of Cerebellar Granule Cell Neuroprecursors
J. Neurosci., November 17, 2004; 24(46): 10343 - 10352.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. D. Corrales, G. L. Rocco, S. Blaess, Q. Guo, and A. L. Joyner
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
Development, November 15, 2004; 131(22): 5581 - 5590.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
H. Miura, H. Kato, Y. Kusakabe, M. Tagami, J. Miura-Ohnuma, Y. Ninomiya, and A. Hino
A Strong Nerve Dependence of Sonic hedgehog Expression in Basal Cells in Mouse Taste Bud and an Autonomous Transcriptional Control of Genes in Differentiated Taste Cells
Chem Senses, November 1, 2004; 29(9): 823 - 831.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Di Marcotullio, E. Ferretti, E. De Smaele, B. Argenti, C. Mincione, F. Zazzeroni, R. Gallo, L. Masuelli, M. Napolitano, M. Maroder, et al.
RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
PNAS, July 20, 2004; 101(29): 10833 - 10838.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Rios, R. Alvarez-Rodriguez, E. Marti, and S. Pons
Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling
Development, July 1, 2004; 131(13): 3159 - 3168.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Couve-Privat, M. Le Bret, E. Traiffort, S. Queille, J. Coulombe, B. Bouadjar, M. F. Avril, M. Ruat, A. Sarasin, and L. Daya-Grosjean
Functional Analysis of Novel Sonic Hedgehog Gene Mutations Identified in Basal Cell Carcinomas from Xeroderma Pigmentosum Patients
Cancer Res., May 15, 2004; 64(10): 3559 - 3565.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Canzoniere, S. Farioli-Vecchioli, F. Conti, M. T. Ciotti, A. M. Tata, G. Augusti-Tocco, E. Mattei, M. K. Lakshmana, V. Krizhanovsky, S. A. Reeves, et al.
Dual Control of Neurogenesis by PC3 through Cell Cycle Inhibition and Induction of Math1
J. Neurosci., March 31, 2004; 24(13): 3355 - 3369.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Blaess, D. Graus-Porta, R. Belvindrah, R. Radakovits, S. Pons, A. Littlewood-Evans, M. Senften, H. Guo, Y. Li, J. H. Miner, et al.
{beta}1-Integrins Are Critical for Cerebellar Granule Cell Precursor Proliferation
J. Neurosci., March 31, 2004; 24(13): 3402 - 3412.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Kessaris, F. Jamen, L. L. Rubin, and W. D. Richardson
Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors
Development, March 15, 2004; 131(6): 1289 - 1298.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Okano-Uchida, T. Himi, Y. Komiya, and Y. Ishizaki
Cerebellar granule cell precursors can differentiate into astroglial cells
PNAS, February 3, 2004; 101(5): 1211 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Palma and A. R. i Altaba
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex
Development, January 15, 2004; 131(2): 337 - 345.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Moshiri and T. A. Reh
Persistent Progenitors at the Retinal Margin of ptc+/- Mice
J. Neurosci., January 7, 2004; 24(1): 229 - 237.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
K. Kasai, M. Takahashi, N. Osumi, S. Sinnarajah, T. Takeo, H. Ikeda, J. H. Kehrl, G. Itoh, and H. Arnheiter
The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling
Genes Cells, January 1, 2004; 9(1): 49 - 58.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. M. Kenney, H. R. Widlund, and D. H. Rowitch
Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
Development, January 1, 2004; 131(1): 217 - 228.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Gulacsi and L. Lillien
Sonic Hedgehog and Bone Morphogenetic Protein Regulate Interneuron Development from Dorsal Telencephalic Progenitors In Vitro
J. Neurosci., October 29, 2003; 23(30): 9862 - 9872.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Mathis, L. Collin, and E. Borrelli
Oligodendrocyte ablation impairs cerebellum development
Development, October 1, 2003; 130(19): 4709 - 4718.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
M. V. Chao
Dependence Receptors: What Is the Mechanism?
Sci. Signal., September 16, 2003; 2003(200): pe38 - pe38.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Bouslama-Oueghlani, R. Wehrle, C. Sotelo, and I. Dusart
The Developmental Loss of the Ability of Purkinje Cells to Regenerate Their Axons Occurs in the Absence of Myelin: An In Vitro Model to Prevent Myelination
J. Neurosci., September 10, 2003; 23(23): 8318 - 8329.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. G. Oliver, L. L. Grasfeder, A. L. Carroll, C. Kaiser, C. L. Gillingham, S. M. Lin, R. Wickramasinghe, M. P. Scott, and R. J. Wechsler-Reya
Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors
PNAS, June 10, 2003; 100(12): 7331 - 7336.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
I. Foucher, M. L. Montesinos, M. Volovitch, A. Prochiantz, and A. Trembleau
Joint regulation of the MAP1B promoter by HNF3{beta}/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors
Development, May 1, 2003; 130(9): 1867 - 1876.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
E. Roessler and M. Muenke
How a Hedgehog might see holoprosencephaly
Hum. Mol. Genet., April 2, 2003; 12(90001): R15 - 25.
[Abstract] [Full Text] [PDF]

Home page
 Development