|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 14 3149-3157, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
P zur Lage and AP Jarman
Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh, EH9 3JR, UK.
The selection of Drosophila melanogaster sense organ precursors (SOPs) for sensory bristles is a progressive process: each neural equivalence group is transiently defined by the expression of proneural genes (proneural cluster), and neural fate is refined to single cells by Notch-Delta lateral inhibitory signalling between the cells. Unlike sensory bristles, SOPs of chordotonal (stretch receptor) sense organs are tightly clustered. Here we show that for one large adult chordotonal SOP array, clustering results from the progressive accumulation of a large number of SOPs from a persistent proneural cluster. This is achieved by a novel interplay of inductive epidermal growth factor-receptor (EGFR) and competitive Notch signals. EGFR acts in opposition to Notch signalling in two ways: it promotes continuous SOP recruitment despite lateral inhibition, and it attenuates the effect of lateral inhibition on the proneural cluster equivalence group, thus maintaining the persistent proneural cluster. SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs.
This article has been cited by other articles:
|
|
 |
|
  B. W. Purow, T. K. Sundaresan, M. J. Burdick, B. A. Kefas, L. D. Comeau, M. P. Hawkinson, Q. Su, Y. Kotliarov, J. Lee, W. Zhang, et al. Notch-1 regulates transcription of the epidermal growth factor receptor through p53 Carcinogenesis, May 1, 2008; 29(5): 918 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Yool Aquaporins: Multiple Roles in the Central Nervous System Neuroscientist, October 1, 2007; 13(5): 470 - 485. [Abstract] [PDF]
|
|
|
|
 |
|
 P. S. Hodkinson, Paul. A. Elliott, Y. Lad, B. J. McHugh, A. C. MacKinnon, C. Haslett, and T. Sethi Mammalian NOTCH-1 Activates beta1 Integrins via the Small GTPase R-Ras J. Biol. Chem., September 28, 2007; 282(39): 28991 - 29001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Sprecher, F. Pichaud, and C. Desplan Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates Genes & Dev., September 1, 2007; 21(17): 2182 - 2195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Sukhanova, D. K. Deb, G. M. Gordon, M. T. Matakatsu, and W. Du Proneural Basic Helix-Loop-Helix Proteins and Epidermal Growth Factor Receptor Signaling Coordinately Regulate Cell Type Specification and cdk Inhibitor Expression during Development Mol. Cell. Biol., April 15, 2007; 27(8): 2987 - 2996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-Z. Shilo Regulating the dynamics of EGF receptor signaling in space and time Development, September 15, 2005; 132(18): 4017 - 4027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Sundaram The love-hate relationship between Ras and Notch Genes & Dev., August 15, 2005; 19(16): 1825 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Matsuda, Y. Wakamatsu, J. Kohyama, H. Okano, K. Fukuda, and S. Yasugi Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development Development, June 15, 2005; 132(12): 2783 - 2793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Daudet and J. Lewis Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation Development, February 1, 2005; 132(3): 541 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Rawlins, N. M. White, and A. P. Jarman Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups Development, August 15, 2003; 130(16): 3715 - 3724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cau and S. W. Wilson Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis Development, June 1, 2003; 130(11): 2455 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Lai Drosophila Tufted Is a Gain-of-Function Allele of the Proneural Gene amos Genetics, April 1, 2003; 163(4): 1413 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Frankfort and G. Mardon R8 development in the Drosophila eye: a paradigm for neural selection and differentiation Development, March 5, 2003; 129(6): 1295 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sudarsan, S. Pasalodos-Sanchez, S. Wan, A. Gampel, and H. Skaer A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila Development, March 4, 2003; 129(4): 935 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Pi, H.-J. Wu, and C.-T. Chien A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny Development, July 15, 2001; 128(14): 2699 - 2710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Culi, E Martin-Blanco, and J Modolell The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning Development, January 1, 2001; 128(2): 299 - 308. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Eddison, I. Le Roux, and J. Lewis Notch signaling in the development of the inner ear: Lessons from Drosophila PNAS, October 24, 2000; 97(22): 11692 - 11699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Hassan and H. J. Bellen Doing the MATH: is the mouse a good model for fly development? Genes & Dev., August 1, 2000; 14(15): 1852 - 1865. [Full Text]
|
|
|
|
|
|
B Kuang, S. Wu, Y Shin, L Luo, and P Kolodziej split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo Development, January 4, 2000; 127(7): 1517 - 1529. [Abstract] [PDF]
|
|
|
|
|
|
N. White and A. Jarman Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling Development, January 4, 2000; 127(8): 1681 - 1689. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Berset, E. F. Hoier, G. Battu, S. Canevascini, and A. Hajnal Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During C. elegans Vulval Development Science, February 9, 2001; 291(5506): 1055 - 1058. [Abstract] [Full Text]
|
|
