spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Theil, T.
Right arrow Articles by Ruther, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Theil, T.
Right arrow Articles by Ruther, U.

Development, Vol 126, Issue 16 3561-3571, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Gli3 is required for Emx gene expression during dorsal telencephalon development

T Theil, G Alvarez-Bolado, A Walter and U Ruther
Institute for Molecular Biology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. thomas. theil@uni-duesseldorf.de

Dentate gyrus and hippocampus as centers for spatial learning, memory and emotional behaviour have been the focus of much interest in recent years. The molecular information on its development, however, has been relatively poor. To date, only Emx genes were known to be required for dorsal telencephalon development. Here, we report on forebrain development in the extra toes (Xt(J)) mouse mutant which carries a null mutation of the Gli3 gene. This defect leads to a failure to establish the dorsal di-telencephalic junction and finally results in a severe size reduction of the neocortex. In addition, Xt(J)/Xt(J) mice show absence of the hippocampus (Ammon's horn plus dentate gyrus) and the choroid plexus in the lateral ventricle. The medial wall of the telencephalon, which gives rise to these structures, fails to invaginate during embryonic development. On a molecular level, disruption of dorsal telencephalon development in Xt(J)/Xt(J) embryos correlates with a loss of Emx1 and Emx2 expression. Furthermore, the expression of Fgf8 and Bmp4 in the dorsal midline of the telencephalon is altered. However, expression of Shh, which is negatively regulated by Gli3 in the spinal cord, is not affected in the Xt(J)/Xt(J) forebrain. This study therefore implicates Gli3 as a key regulator for the development of the dorsal telencephalon and implies Gli3 to be upstream of Emx genes in a genetic cascade controlling dorsal telencephalic development.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. A. Willaredt, K. Hasenpusch-Theil, H. A. R. Gardner, I. Kitanovic, V. C. Hirschfeld-Warneken, C. P. Gojak, K. Gorgas, C. L. Bradford, J. Spatz, S. Wolfl, et al.
A Crucial Role for Primary Cilia in Cortical Morphogenesis
J. Neurosci., November 26, 2008; 28(48): 12887 - 12900.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. S. Tucker, S. Segall, D. Gopalakrishna, Y. Wu, M. Vernon, F. Polleux, and A.-S. LaMantia
Molecular Specification and Patterning of Progenitor Cells in the Lateral and Medial Ganglionic Eminences
J. Neurosci., September 17, 2008; 28(38): 9504 - 9518.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. Mattar, L. M. Langevin, K. Markham, N. Klenin, S. Shivji, D. Zinyk, and C. Schuurmans
Basic Helix-Loop-Helix Transcription Factors Cooperate To Specify a Cortical Projection Neuron Identity
Mol. Cell. Biol., March 1, 2008; 28(5): 1456 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Fernandes, G. Gutin, H. Alcorn, S. K. McConnell, and J. M. Hebert
Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly
Development, November 1, 2007; 134(21): 3789 - 3794.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. G. Rash and E. A. Grove
Patterning the Dorsal Telencephalon: A Role for Sonic Hedgehog?
J. Neurosci., October 24, 2007; 27(43): 11595 - 11603.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Willaime-Morawek, R. M. Seaberg, C. Batista, E. Labbe, L. Attisano, J. A. Gorski, K. R. Jones, A. Kam, C. M. Morshead, and D. van der Kooy
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
J. Cell Biol., October 9, 2006; 175(1): 159 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Fotaki, T. Yu, P. A. Zaki, J. O. Mason, and D. J. Price
Abnormal Positioning of Diencephalic Cell Types in Neocortical Tissue in the Dorsal Telencephalon of Mice Lacking Functional Gli3
J. Neurosci., September 6, 2006; 26(36): 9282 - 9292.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Gutin, M. Fernandes, L. Palazzolo, H. Paek, K. Yu, D. M. Ornitz, S. K. McConnell, and J. M. Hebert
FGF signalling generates ventral telencephalic cells independently of SHH
Development, August 1, 2006; 133(15): 2937 - 2946.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation.
Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Ribes, Z. Wang, P. Dolle, and K. Niederreither
Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling
Development, January 15, 2006; 133(2): 351 - 361.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba
Cooperative requirement of the Gli proteins in neurogenesis
Development, July 15, 2005; 132(14): 3267 - 3279.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. Laub, L. Lei, H. Sumiyoshi, D. Kajimura, C. Dragomir, S. Smaldone, A. C. Puche, T. J. Petros, C. Mason, L. F. Parada, et al.
Transcription Factor KLF7 Is Important for Neuronal Morphogenesis in Selected Regions of the Nervous System
Mol. Cell. Biol., July 1, 2005; 25(13): 5699 - 5711.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Palma and A. R. i Altaba
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex
Development, January 15, 2004; 131(2): 337 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. Muzio and A. Mallamaci
Emx1, Emx2 and Pax6 in Specification, Regionalization and Arealization of the Cerebral Cortex
Cereb Cortex, June 1, 2003; 13(6): 641 - 647.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Wijgerde, J. A. McMahon, M. Rule, and A. P. McMahon
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
Genes & Dev., November 15, 2002; 16(22): 2849 - 2864.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
Genes & Dev., November 15, 2002; 16(22): 2865 - 2878.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. M. Bishop, J. L. R. Rubenstein, and D. D. M. O'Leary
Distinct Actions of Emx1, Emx2, and Pax6 in Regulating the Specification of Areas in the Developing Neocortex
J. Neurosci., September 1, 2002; 22(17): 7627 - 7638.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Huang, H. Roelink, and G. S. McKnight
Protein Kinase A Deficiency Causes Axially Localized Neural Tube Defects in Mice
J. Biol. Chem., May 24, 2002; 277(22): 19889 - 19896.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Bose, L. Grotewold, and U. Ruther
Pallister-Hall syndrome phenotype in mice mutant for Gli3
Hum. Mol. Genet., May 1, 2002; 11(9): 1129 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. A. Martin, S.-S. Tan, and D. Goldowitz
Clonal Architecture of the Mouse Hippocampus
J. Neurosci., May 1, 2002; 22(9): 3520 - 3530.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Rallu, R. Machold, N. Gaiano, J. G. Corbin, A. P. McMahon, and G. Fishell
Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling
Development, January 11, 2002; 129(21): 4963 - 4974.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Theil, S. Aydin, S. Koch, L. Grotewold, and U. Ruther
Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon
Development, January 7, 2002; 129(13): 3045 - 3054.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. B. Bai and A. L. Joyner
Gli1 can rescue the in vivo function of Gli2
Development, December 15, 2001; 128(24): 5161 - 5172.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Dahmane, P. Sanchez, Y. Gitton, V. Palma, T. Sun, M. Beyna, H. Weiner, and A. Ruiz i Altaba
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
Development, December 15, 2001; 128(24): 5201 - 5212.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Tomioka, N. Osumi, Y. Sato, T. Inoue, S. Nakamura, H. Fujisawa, and T. Hirata
Neocortical Origin and Tangential Migration of Guidepost Neurons in the Lateral Olfactory Tract
J. Neurosci., August 1, 2000; 20(15): 5802 - 5812.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. M. Bishop, G. Goudreau, and D. D. O'Leary
Regulation of Area Identity in the Mammalian Neocortex by Emx2 and Pax6
Science, April 14, 2000; 288(5464): 344 - 349.
[Abstract] [Full Text]


© The Company of Biologists Ltd 1999