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Development, Vol 126, Issue 21 4903-4911, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
D Clements, RV Friday and HR Woodland
Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK. hw@dna.bio.warwick.ac.uk.
mRNA encoding the T-box transcription factor VegT is located throughout the vegetal pole of the Xenopus egg and is believed to play an important part in endoderm and mesoderm formation. We find that VegT generates endoderm both by cell-autonomous action and by generating TGF-beta family signals, the latter being entirely responsible for its mesoderm-inducing activity. Signalling molecules induced cell-autonomously by VegT include derriere, Xnr4 and activin B. Xnr1 and Xnr2 are also induced, but primarily in a non-autonomous manner. All of these signalling molecules are found in the blastula and gastrula vegetal pole and induce both endoderm and mesoderm in the animal cap assay, and hence are good candidates both for the endogenous zygotic mesoderm-inducing signal and for reinforcing the vegetal expression of endoderm markers.
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