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Development, Vol 126, Issue 23 5421-5429, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
J Chae, MJ Kim, JH Goo, S Collier, D Gubb, J Charlton, PN Adler and WJ Park
Department of Life Science, Kwangju Institute of Science and Technology (K-JIST), Kwangju, Korea.
The tissue polarity genes control the polarity of hairs, bristles and ommatidia in the adult epidermis of Drosophila. We report here the identification of a new tissue polarity gene named starry night (stan). Mutations in this essential gene alter the polarity of cuticular structures in all regions of the adult body. The detailed polarity phenotype of stan on the wing suggested that it is most likely a component of the frizzled (fz) pathway. Consistent with this hypothesis, stan appears to be downstream of and required for fz function. We molecularly cloned stan and found that it encodes a huge protocadherin containing nine cadherin motifs, four EGF-like motifs, two laminin G motifs, and seven transmembrane domains. This suggests that Stan functions in signal reception, perhaps together with Fz.
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