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Development, Vol 126, Issue 5 1023-1029, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Induction of indora expression in pole cells by the mesoderm is required for female germ-line development in Drosophila melanogaster

M Mukai, M Kashikawa and S Kobayashi
Institute of Biological Sciences, Gene Experiment Center and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305, Japan.

In many animal groups, the interaction between germ and somatic line is required for germ-line development. In Drosophila, the germ-line precursors (pole cells) formed at the posterior tip of the embryos migrate toward the mesodermal layer where they adhere to the dorsolateral mesoderm, which ensheaths the pole cells to form the embryonic gonads. These mesodermal cells may control the expression of genes that function in pole cells for their development into germ cells. However, such downstream genes have not been isolated. In this study, we identify a novel transcript, indora (idr), which is expressed only in pole cells within the gonads. Reduction of idr transcripts by an antisense idr expression caused the failure of pole cells to produce functional germ cells in females. Furthermore, we demonstrate that idr expression depends on the presence of the dorsolateral mesoderm, but it does not necessarily require its specification as the gonadal mesoderm. Our findings suggest that the induction of idr in pole cells by the mesodermal cells is required for germ-line development.


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© The Company of Biologists Ltd 1999