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Development, Vol 126, Issue 7 1505-1514, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
C Englund, AE Uv, R Cantera, LD Mathies, MA Krasnow and C Samakovlis
Umea Center for Molecular Pathogenesis, Umea University, S-90187 Umea, Sweden. christos@ucmp.umu.se
Neurons and glial cells provide guidance cues for migrating neurons. We show here that migrating epithelial cells also contact specific neurons and glia during their pathfinding, and we describe the first gene required in the process. In wild-type Drosophila embryos, the ganglionic tracheal branch navigates a remarkably complex path along specific neural and glial substrata, switching substrata five times before reaching its ultimate target in the CNS. In adrift mutants, ganglionic branches migrate normally along the intersegmental nerve, but sporadically fail to switch to the segmental nerve and enter the CNS; they wind up meandering along the ventral epidermis instead. adrift encodes a novel nuclear protein with an evolutionarily conserved motif. The gene is required in the trachea and is expressed in the leading cells of migrating ganglionic branches where it is induced by the branchless FGF pathway. We propose that Adrift regulates expression of tracheal genes required for pathfinding on the segmental nerve, and FGF induction of adrift expression in migrating tracheal cells promotes the switch from the intersegmental to the segmental nerve.
This article has been cited by other articles:
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  T. E. Rusten, L. M.W. Rodahl, K. Pattni, C. Englund, C. Samakovlis, S. Dove, A. Brech, and H. Stenmark Fab1 Phosphatidylinositol 3-Phosphate 5-Kinase Controls Trafficking but Not Silencing of Endocytosed Receptors Mol. Biol. Cell, September 1, 2006; 17(9): 3989 - 4001. [Abstract] [Full Text] [PDF]
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 A. Lundstrom, M. Gallio, C. Englund, P. Steneberg, J. Hemphala, P. Aspenstrom, K. Keleman, L. Falileeva, B. J. Dickson, and C. Samakovlis Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons Genes & Dev., September 1, 2004; 18(17): 2161 - 2171. [Abstract] [Full Text] [PDF]
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 M. Gallio, C. Englund, P. Kylsten, and C. Samakovlis Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline Development, August 1, 2004; 131(15): 3605 - 3614. [Abstract] [Full Text] [PDF]
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J. Hemphala, A. Uv, R. Cantera, S. Bray, and C. Samakovlis Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling Development, March 2, 2003; 130(2): 249 - 258. [Abstract] [Full Text] [PDF]
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 S. Lavista-Llanos, L. Centanin, M. Irisarri, D. M. Russo, J. M. Gleadle, S. N. Bocca, M. Muzzopappa, P. J. Ratcliffe, and P. Wappner Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar Mol. Cell. Biol., October 1, 2002; 22(19): 6842 - 6853. [Abstract] [Full Text] [PDF]
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 S. E. Mohr and W. M. Gelbart Using the P{wHy} Hybrid Transposable Element to Disrupt Genes in Region 54D-55B in Drosophila melanogaster Genetics, September 1, 2002; 162(1): 165 - 176. [Abstract] [Full Text] [PDF]
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C. Englund, P. Steneberg, L. Falileeva, N. Xylourgidis, and C. Samakovlis Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea Development, January 11, 2002; 129(21): 4941 - 4951. [Abstract] [Full Text] [PDF]
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A. E. Uv, P. Roth, N. Xylourgidis, A. Wickberg, R. Cantera, and C. Samakovlis members only encodes a Drosophila nucleoporin required for Rel protein import and immune response activation Genes & Dev., August 1, 2000; 14(15): 1945 - 1957. [Abstract] [Full Text]
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M Llimargas Wingless and its signalling pathway have common and separable functions during tracheal development Development, January 10, 2000; 127(20): 4407 - 4417. [Abstract] [PDF]
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A Schmid, A Chiba, and C. Doe Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets Development, January 11, 1999; 126(21): 4653 - 4689. [Abstract] [PDF]
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