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Development, Vol 126, Issue 9 1859-1868, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Novel guidance cues during neuronal pathfinding in the early scaffold of axon tracts in the rostral brain

RB Anderson and B Key
Neurodevelopment Laboratory, Department of Anatomy and Cell Biology, University of Melbourne, Parkville 3052, Australia.

A scaffold of axons consisting of a pair of longitudinal tracts and several commissures is established during early development of the vertebrate brain. We report here that NOC-2, a cell surface carbohydrate, is selectively expressed by a subpopulation of growing axons in this scaffold in Xenopus. NOC-2 is present on two glycoproteins, one of which is a novel glycoform of the neural cell adhesion molecule N-CAM. When the function of NOC-2 was perturbed using either soluble carbohydrates or anti-NOC-2 antibodies, axons expressing NOC-2 exhibited aberrant growth at specific points in their pathway. NOC-2 is the first-identified axon guidance molecule essential for development of the axon scaffold in the embryonic vertebrate brain.


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© The Company of Biologists Ltd 1999