spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhao, X.
Right arrow Articles by Paria, B. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhao, X.
Right arrow Articles by Paria, B. C.

Development, Vol 127, Issue 12 2643-2651, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Blastocyst H(2) receptor is the target for uterine histamine in implantation in the mouse

X Zhao, W Ma, SK Das, SK Dey and BC Paria
Departments of Molecular and Integrative Physiology, Obstetrics and Gynecology and Pediatrics, Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160-7338, USA.

The process of implantation is a 'two-way' interaction between the blastocyst and uterus. It has long been suspected that histamine is an important mediator in embryo-uterine interactions during implantation, but its source, targets and mechanism of actions remained undefined. We have recently demonstrated that uterine epithelial cells are the source of histamine, which peaks on day 4 of pregnancy (the day of implantation) in the mouse. In searching for its target and site of action, we discovered that preimplantation blastocysts, which express histamine type 2 receptor (H(2)), is the target for histamine action. Using multiple approaches, we demonstrate herein that uterine-derived histamine interacts with embryonic H(2) receptors in a paracrine fashion to initiate the process of implantation.


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
S. R. Hansson, B. Bottalico, V. Noskova, and B. Casslen
Monoamine transporters in human endometrium and decidua
Hum. Reprod. Update, November 5, 2008; (2008) dmn048v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
L. Maintz, V. Schwarzer, T. Bieber, K. van der Ven, and N. Novak
Effects of histamine and diamine oxidase activities on pregnancy: a critical review
Hum. Reprod. Update, September 1, 2008; 14(5): 485 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
V. Noskova, B. Bottalico, H. Olsson, A. Ehinger, R. Pilka, B. Casslen, and S. R. Hansson
Histamine uptake by human endometrial cells expressing the organic cation transporter EMT and the vesicular monoamine transporter-2
Mol. Hum. Reprod., August 1, 2006; 12(8): 483 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. Mondillo, Z. Patrignani, C. Reche, E. Rivera, and O. Pignataro
Dual Role of Histamine in Modulation of Leydig Cell Steroidogenesis via HRH1 and HRH2 Receptor Subtypes
Biol Reprod, November 1, 2005; 73(5): 899 - 907.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. K. Dey, H. Lim, S. K. Das, J. Reese, B. C. Paria, T. Daikoku, and H. Wang
Molecular Cues to Implantation
Endocr. Rev., June 1, 2004; 25(3): 341 - 373.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000