|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 13 2773-2784, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
C Wu, Q Zeng, KJ Blumer and AJ Muslin
Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
RGS family members are GTPase activating proteins (GAPs) that antagonize signaling by heterotrimeric G proteins. Injection of Xenopus embryos with RNA encoding rat RGS4 (rRGS4), a GAP for G(i) and G(q), resulted in shortened trunks and decreased skeletal muscle. This phenotype is nearly identical to the effect of injection of either frzb or dominant negative Xwnt-8. Injection of human RGS2, which selectively deactivates G(q), had similar effects. rRGS4 inhibited the ability of early Xwnt-8 but not Xdsh misexpression to cause axis duplication. This effect is distinct from axin family members that contain RGS-like domains but act downstream of Xdsh. We identified two Xenopus RGS4 homologs, one of which, Xrgs4a, was expressed as a Spemann organizer component. Injection of Xenopus embryos with Xrgs4a also resulted in shortened trunks and decreased skeletal muscle. These results suggest that RGS proteins modulate Xwnt-8 signaling by attenuating the function of a G protein.
This article has been cited by other articles:
|
|
 |
|
  M. E. Feigin and C. C. Malbon RGS19 regulates Wnt beta-catenin signaling through inactivation of G{alpha}o J. Cell Sci., October 1, 2007; 120(19): 3404 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Grillet, A. Pattyn, C. Contet, B. L. Kieffer, C. Goridis, and J.-F. Brunet Generation and Characterization of Rgs4 Mutant Mice Mol. Cell. Biol., May 15, 2005; 25(10): 4221 - 4228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schwable, C. Choudhary, C. Thiede, L. Tickenbrock, B. Sargin, C. Steur, M. Rehage, A. Rudat, C. Brandts, W. E. Berdel, et al. RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation Blood, March 1, 2005; 105(5): 2107 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Grillet, V. Dubreuil, H. D. Dufour, and J.-F. Brunet Dynamic Expression of RGS4 in the Developing Nervous System and Regulation by the Neural Type-Specific Transcription Factor Phox2b J. Neurosci., November 19, 2003; 23(33): 10613 - 10621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-y. Wang and C. C. Malbon Wnt Signaling, Ca2+, and Cyclic GMP: Visualizing Frizzled Functions Science, June 6, 2003; 300(5625): 1529 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yang, C. Tan, R. S. Darken, P. A. Wilson, and P. S. Klein {beta}-Catenin/Tcf-regulated transcription prior to the midblastula transition Development, March 14, 2003; 129(24): 5743 - 5752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hollinger and J. R. Hepler Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling Pharmacol. Rev., September 1, 2002; 54(3): 527 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Liu, A. J. DeCostanzo, X. Liu, H.-y. Wang, S. Hallagan, R. T. Moon, and C. C. Malbon G Protein Signaling from Activated Rat Frizzled-1 to the beta -Catenin-Lef-Tcf Pathway Science, June 1, 2001; 292(5522): 1718 - 1722. [Abstract] [Full Text] [PDF]
|
|
