|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 13 2955-2963, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
F Cammas, M Mark, P Dolle, A Dierich, P Chambon and R Losson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/ULP/College de France, BP 163, France.
TIF1beta, a member of the transcriptional intermediary factor 1 family, has been reported to function as a corepressor for the large class of KRAB domain-containing zinc finger proteins of the Kruppel type. To address the biological function of TIF1beta, we have generated TIF1beta-deficient mice by gene disruption. TIF1beta protein was detected in wild-type but not TIF1beta(-/-) blastocysts. Homozygous mutant embryos, which developed normally until the blastocyst stage and underwent uterine implantation, were arrested in their development at the early egg-cylinder stage at about embryonic day (E) 5.5 and were completely resorbed by E8.5. Taken together, these results provide genetic evidence that TIF1beta is a developmental regulatory protein that exerts function(s) essential for early postimplantation development.
This article has been cited by other articles:
|
|
 |
|
  D. Wolf, K. Hug, and S. P. Goff TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cells PNAS, August 26, 2008; 105(34): 12521 - 12526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wiznerowicz, J. Jakobsson, J. Szulc, S. Liao, A. Quazzola, F. Beermann, P. Aebischer, and D. Trono The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis J. Biol. Chem., November 23, 2007; 282(47): 34535 - 34541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Yang, S. M. O'Herrin, J. Wu, S. Reagan-Shaw, Y. Ma, K. M.R. Bhat, C. Gravekamp, V. Setaluri, N. Peters, F. M. Hoffmann, et al. MAGE-A, mMage-b, and MAGE-C Proteins Form Complexes with KAP1 and Suppress p53-Dependent Apoptosis in MAGE-Positive Cell Lines Cancer Res., October 15, 2007; 67(20): 9954 - 9962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, F. J. Rauscher III, W. D. Cress, and J. Chen Regulation of E2F1 Function by the Nuclear Corepressor KAP1 J. Biol. Chem., October 12, 2007; 282(41): 29902 - 29909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. H. Mascle, D. Germain-Desprez, P. Huynh, P. Estephan, and M. Aubry Sumoylation of the Transcriptional Intermediary Factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger Proteins, Is Required for Its Transcriptional Activity and Is Modulated by the KRAB Domain J. Biol. Chem., April 6, 2007; 282(14): 10190 - 10202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Torres-Padilla and M. Zernicka-Goetz Role of TIF1{alpha} as a modulator of embryonic transcription in the mouse zygote J. Cell Biol., July 31, 2006; 174(3): 329 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Beckstead, S. S. Ner, K. G. Hales, T. A. Grigliatti, B. S. Baker, and H. J. Bellen Bonus, a Drosophila TIF1 Homolog, Is a Chromatin-Associated Protein That Acts as a Modifier of Position-Effect Variegation Genetics, February 1, 2005; 169(2): 783 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Khetchoumian, M. Teletin, M. Mark, T. Lerouge, M. Cervino, M. Oulad-Abdelghani, P. Chambon, and R. Losson TIF1{delta}, a Novel HP1-interacting Member of the Transcriptional Intermediary Factor 1 (TIF1) Family Expressed by Elongating Spermatids J. Biol. Chem., November 12, 2004; 279(46): 48329 - 48341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cammas, M. Herzog, T. Lerouge, P. Chambon, and R. Losson Association of the transcriptional corepressor TIF1{beta} with heterochromatin protein 1 (HP1): an essential role for progression through differentiation Genes & Dev., September 1, 2004; 18(17): 2147 - 2160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Weber, F. Cammas, C. Gerard, D. Metzger, P. Chambon, R. Losson, and M. Mark Germ cell expression of the transcriptional co-repressor TIF1{beta} is required for the maintenance of spermatogenesis in the mouse Development, March 7, 2003; 129(10): 2329 - 2337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kerkhoff, H. A. Hofmann, J. Vormoor, H. Melkonyan, J. Roth, C. Sorg, and M. Klempt Binding of Two Nuclear Complexes to a Novel Regulatory Element within the Human S100A9 Promoter Drives the S100A9 Gene Expression J. Biol. Chem., October 25, 2002; 277(44): 41879 - 41887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cammas, M. Oulad-Abdelghani, J.-L. Vonesch, Y. Huss-Garcia, P. Chambon, and R. Losson Cell differentiation induces TIF1{beta} association with centromeric heterochromatin via an HP1 interaction J. Cell Sci., January 9, 2002; 115(17): 3439 - 3448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Abrink, J. A. Ortiz, C. Mark, C. Sanchez, C. Looman, L. Hellman, P. Chambon, and R. Losson Conserved interaction between distinct Kruppel-associated box domains and the transcriptional intermediary factor 1 beta PNAS, February 13, 2001; 98(4): 1422 - 1426. [Abstract] [Full Text] [PDF]
|
|
