|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 16 3619-3629, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
U Weber, N Paricio and M Mlodzik
European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, Germany.
Jun acts as a signal-regulated transcription factor in many cellular decisions, ranging from stress response to proliferation control and cell fate induction. Genetic interaction studies have suggested that Jun and JNK signaling are involved in Frizzled (Fz)-mediated planar polarity generation in the Drosophila eye. However, simple loss-of-function analysis of JNK signaling components did not show comparable planar polarity defects. To address the role of Jun and JNK in Fz signaling, we have used a combination of loss- and gain-of-function studies. Like Fz, Jun affects the bias between the R3/R4 photoreceptor pair that is critical for ommatidial polarity establishment. Detailed analysis of jun(-) clones reveals defects in R3 induction and planar polarity determination, whereas gain of Jun function induces the R3 fate and associated polarity phenotypes. We find also that affecting the levels of JNK signaling by either reduction or overexpression leads to planar polarity defects. Similarly, hypomorphic allelic combinations and overexpression of the negative JNK regulator Puckered causes planar polarity eye phenotypes, establishing that JNK acts in planar polarity signaling. The observation that Dl transcription in the early R3/R4 precursor cells is deregulated by Jun or Hep/JNKK activation, reminiscent of the effects seen with Fz overexpression, suggests that Jun is one of the transcription factors that mediates the effects of fz in planar polarity generation.
This article has been cited by other articles:
|
|
 |
|
  S. B. Uthaman, T. A. Godenschwege, and R. K. Murphey A Mechanism Distinct from Highwire for the Drosophila Ubiquitin Conjugase Bendless in Synaptic Growth and Maturation J. Neurosci., August 20, 2008; 28(34): 8615 - 8623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mathieu, H.-H. Sung, C. Pugieux, J. Soetaert, and P. Rorth A Sensitized PiggyBac-Based Screen for Regulators of Border Cell Migration in Drosophila Genetics, July 1, 2007; 176(3): 1579 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chung, S. Kim, J. Yoon, P. N. Adler, and J. Yim The Balance Between the Novel Protein Target of Wingless and the Drosophila Rho-Associated Kinase Pathway Regulates Planar Cell Polarity in the Drosophila Wing Genetics, June 1, 2007; 176(2): 891 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Srivastava, J. C. Pastor-Pareja, T. Igaki, R. Pagliarini, and T. Xu Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion PNAS, February 20, 2007; 104(8): 2721 - 2726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Hueber, D. Bezdan, S. R. Henz, M. Blank, H. Wu, and I. Lohmann Comparative analysis of Hox downstream genes in Drosophila Development, January 15, 2007; 134(2): 381 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Uhlirova, H. Jasper, and D. Bohmann Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model PNAS, September 13, 2005; 102(37): 13123 - 13128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-H. Cha, S. Kim, J. Park, E. Lee, M. Kim, S. B. Lee, J. M. Kim, J. Chung, and K. S. Cho Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila PNAS, July 19, 2005; 102(29): 10345 - 10350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-H. Cha, K. S. Cho, J. H. Lee, M. Kim, E. Kim, J. Park, S. B. Lee, and J. Chung Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-{kappa}B-Dependent Signaling Pathways Mol. Cell. Biol., November 15, 2003; 23(22): 7982 - 7991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Strutt Frizzled signalling and cell polarisation in Drosophila and vertebrates Development, October 1, 2003; 130(19): 4501 - 4513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. LaVoie and D. J. Selkoe The Notch Ligands, Jagged and Delta, Are Sequentially Processed by {alpha}-Secretase and Presenilin/{gamma}-Secretase and Release Signaling Fragments J. Biol. Chem., September 5, 2003; 278(36): 34427 - 34437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Esteve, F. Trousse, J. Rodriguez, and P. Bovolenta SFRP1 modulates retina cell differentiation through a {beta}-catenin-independent mechanism J. Cell Sci., June 15, 2003; 116(12): 2471 - 2481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Parnell, B. S. Magenheimer, R. L. Maser, C. A. Zien, A.-M. Frischauf, and J. P. Calvet Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins J. Biol. Chem., May 24, 2002; 277(22): 19566 - 19572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Van Aelst and M. Symons Role of Rho family GTPases in epithelial morphogenesis Genes & Dev., May 1, 2002; 16(9): 1032 - 1054. [Full Text] [PDF]
|
|
|
|
|
|
B. Stronach and N. Perrimon Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper Genes & Dev., February 1, 2002; 16(3): 377 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Pickup, M. L. Lamka, Q. Sun, M. L. R. Yip, and H. D. Lipshitz Control of photoreceptor cell morphology, planar polarity and epithelial integrity during Drosophila eye development Development, January 5, 2002; 129(9): 2247 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ciapponi, D. B. Jackson, M. Mlodzik, and D. Bohmann Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites Genes & Dev., June 15, 2001; 15(12): 1540 - 1553. [Abstract] [Full Text] [PDF]
|
|
