Development, Vol 127, Issue 8 1737-1749, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development

MS Ko, JR Kitchen, X Wang, TA Threat, X Wang, A Hasegawa, T Sun, MJ Grahovac, GJ Kargul, MK Lim, Y Cui, Y Sano, T Tanaka, Y Liang, S Mason, PD Paonessa, AD Sauls, GE DePalma, R Sharara, LB Rowe, J Eppig, C Morrell and H Doi
ERATO Doi Bioasymmetry Project, JST, Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48202, USA. kom@grc.nia.nih.gov

Little is known about gene action in the preimplantation events that initiate mammalian development. Based on cDNA collections made from each stage from egg to blastocyst, 25438 3'-ESTs were derived, and represent 9718 genes, half of them novel. Thus, a considerable fraction of mammalian genes is dedicated to embryonic expression. This study reveals profound changes in gene expression that include the transient induction of transcripts at each stage. These results raise the possibility that development is driven by the action of a series of stage-specific expressed genes. The new genes, 798 of them placed on the mouse genetic map, provide entry points for analyses of human and mouse developmental disorders.

This article has been cited by other articles:

				T. Hamatani, M. Yamada, H. Akutsu, N. Kuji, Y. Mochimaru, M. Takano, M. Toyoda, K. Miyado, A. Umezawa, and Y. Yoshimura What can we learn from gene expression profiling of mouse oocytes? Reproduction, May 1, 2008; 135(5): 581 - 592. [Abstract] [Full Text] [PDF]

				M. Vallee, K. Aiba, Y. Piao, M.-F. Palin, M. S H Ko, and M.-A. Sirard Comparative analysis of oocyte transcript profiles reveals a high degree of conservation among species Reproduction, April 1, 2008; 135(4): 439 - 448. [Abstract] [Full Text] [PDF]

				E. De La Chesnaye, B. Kerr, A. Paredes, H. Merchant-Larios, J. P. Mendez, and S. R. Ojeda Fbxw15/Fbxo12J Is an F-Box Protein-Encoding Gene Selectively Expressed in Oocytes of the Mouse Ovary Biol Reprod, April 1, 2008; 78(4): 714 - 725. [Abstract] [Full Text] [PDF]

				A Bonnet, R Dalbies-Tran, and M A Sirard Opportunities and challenges in applying genomics to the study of oogenesis and folliculogenesis in farm animals Reproduction, February 1, 2008; 135(2): 119 - 128. [Abstract] [Full Text] [PDF]

				V. Duranthon, A. J Watson, and P. Lonergan Preimplantation embryo programming: transcription, epigenetics, and culture environment Reproduction, February 1, 2008; 135(2): 141 - 150. [Abstract] [Full Text] [PDF]

				J. Adjaye, R. Herwig, T. C. Brink, D. Herrmann, B. Greber, S. Sudheer, D. Groth, J. W. Carnwath, H. Lehrach, and H. Niemann Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression Physiol Genomics, October 19, 2007; 31(2): 315 - 327. [Abstract] [Full Text] [PDF]

				S. Sudheer and J. Adjaye Functional genomics of human pre-implantation development Brief Funct Genomic Proteomic, July 31, 2007; (2007) elm012v1. [Abstract] [Full Text] [PDF]

				G. Roma, G. Cobellis, P. Claudiani, F. Maione, P. Cruz, G. Tripoli, M. Sardiello, I. Peluso, and E. Stupka A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells Genome Res., July 1, 2007; 17(7): 1051 - 1060. [Abstract] [Full Text] [PDF]

				M. E. Pepling, J. E. Wilhelm, A. L. O'Hara, G. W. Gephardt, and A. C. Spradling Mouse oocytes within germ cell cysts and primordial follicles contain a Balbiani body PNAS, January 2, 2007; 104(1): 187 - 192. [Abstract] [Full Text] [PDF]

				L. N. Winteringham, R. Endersby, S. Kobelke, R. K. McCulloch, J. H. Williams, J. Stillitano, S. M. Cornwall, E. Ingley, and S. P. Klinken Myeloid Leukemia Factor 1 Associates with a Novel Heterogeneous Nuclear Ribonucleoprotein U-like Molecule J. Biol. Chem., December 15, 2006; 281(50): 38791 - 38800. [Abstract] [Full Text] [PDF]

				D. Zhang, C. J. Martyniuk, and V. L. Trudeau SANTA domain: a novel conserved protein module in Eukaryota with potential involvement in chromatin regulation Bioinformatics, October 15, 2006; 22(20): 2459 - 2462. [Abstract] [Full Text] [PDF]

				Q. Winger, J. Huang, H. J. Auman, M. Lewandoski, and T. Williams Analysis of Transcription Factor AP-2 Expression and Function During Mouse Preimplantation Development Biol Reprod, September 1, 2006; 75(3): 324 - 333. [Abstract] [Full Text] [PDF]

				H. Wang, S. K. Dey, and M. Maccarrone Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility Endocr. Rev., August 1, 2006; 27(5): 427 - 448. [Abstract] [Full Text] [PDF]

				J. Ma, F. Zeng, R. M. Schultz, and H. Tseng Basonuclin: a novel mammalian maternal-effect gene Development, May 15, 2006; 133(10): 2053 - 2062. [Abstract] [Full Text] [PDF]

				C.-J. Huang, J.-G. Chang, S.-C. Wu, and K.-B. Choo Negative Transcriptional Modulation and Silencing of the Bi-exonic Rnf35 Gene in the Preimplantation Embryo: BINDING OF THE CCAAT-DISPLACEMENT PROTEIN/Cux TO THE UNTRANSLATED EXON 1 SEQUENCE J. Biol. Chem., September 2, 2005; 280(35): 30681 - 30688. [Abstract] [Full Text] [PDF]

				M. Boiani, L. Gentile, V. V. Gambles, F. Cavaleri, C. A. Redi, and H. R. Scholer Variable Reprogramming of the Pluripotent Stem Cell Marker Oct4 in Mouse Clones: Distinct Developmental Potentials in Different Culture Environments Stem Cells, September 1, 2005; 23(8): 1089 - 1104. [Abstract] [Full Text] [PDF]

				K.M. Whitworth, C. Agca, J.-G. Kim, R.V. Patel, G.K. Springer, N.J. Bivens, L.J. Forrester, N. Mathialagan, J.A. Green, and R.S. Prather Transcriptional Profiling of Pig Embryogenesis by Using a 15-K Member Unigene Set Specific for Pig Reproductive Tissues and Embryos Biol Reprod, June 1, 2005; 72(6): 1437 - 1451. [Abstract] [Full Text] [PDF]

				H. Jiang, K. M. Whitworth, N. J. Bivens, J. E. Ries, R. J. Woods, L. J. Forrester, G. K. Springer, N. Mathialagan, C. Agca, R. S. Prather, et al. Large-Scale Generation and Analysis of Expressed Sequence Tags from Porcine Ovary Biol Reprod, December 1, 2004; 71(6): 1991 - 2002. [Abstract] [Full Text] [PDF]

				P. Rinaudo and R. M Schultz Effects of embryo culture on global pattern of gene expression in preimplantation mouse embryos Reproduction, September 1, 2004; 128(3): 301 - 311. [Abstract] [Full Text] [PDF]

				K. A. Hohenstein and D. H. Shain Changes in Gene Expression at the Precursor -> Stem Cell Transition in Leech Stem Cells, July 1, 2004; 22(4): 514 - 521. [Abstract] [Full Text] [PDF]

				N. Beaujean, J. Taylor, J. Gardner, I. Wilmut, R. Meehan, and L. Young Effect of Limited DNA Methylation Reprogramming in the Normal Sheep Embryo on Somatic Cell Nuclear Transfer Biol Reprod, July 1, 2004; 71(1): 185 - 193. [Abstract] [Full Text] [PDF]

				S. Miyagi, T. Saito, K.-i. Mizutani, N. Masuyama, Y. Gotoh, A. Iwama, H. Nakauchi, S. Masui, H. Niwa, M. Nishimoto, et al. The Sox-2 Regulatory Regions Display Their Activities in Two Distinct Types of Multipotent Stem Cells Mol. Cell. Biol., May 15, 2004; 24(10): 4207 - 4220. [Abstract] [Full Text] [PDF]

				X. Wu, P. Wang, C. A. Brown, C. A. Zilinski, and M. M. Matzuk Zygote Arrest 1 (Zar1) Is an Evolutionarily Conserved Gene Expressed in Vertebrate Ovaries Biol Reprod, September 1, 2003; 69(3): 861 - 867. [Abstract] [Full Text] [PDF]

				M. G. Carter, T. Hamatani, A. A. Sharov, C. E. Carmack, Y. Qian, K. Aiba, N. T. Ko, D. B. Dudekula, P. M. Brzoska, S. S. Hwang, et al. In Situ-Synthesized Novel Microarray Optimized for Mouse Stem Cell and Early Developmental Expression Profiling Genome Res., May 1, 2003; 13(5): 1011 - 1021. [Abstract] [Full Text] [PDF]

				L. S. Gammill and M. Bronner-Fraser Genomic analysis of neural crest induction Development, March 14, 2003; 129(24): 5731 - 5741. [Abstract] [Full Text] [PDF]

				F. Zeng and R. M. Schultz Gene Expression in Mouse Oocytes and Preimplantation Embryos: Use of Suppression Subtractive Hybridization to Identify Oocyte- and Embryo-Specific Genes Biol Reprod, January 1, 2003; 68(1): 31 - 39. [Abstract] [Full Text] [PDF]

				S. Pacheco-Trigon, C. Hennequet-Antier, J.-F. Oudin, F. Piumi, J.-P. Renard, and V. Duranthon Molecular Characterization of Genomic Activities at the Onset of Zygotic Transcription in Mammals Biol Reprod, December 1, 2002; 67(6): 1907 - 1918. [Abstract] [Full Text] [PDF]

				Y. Piao, N. T. Ko, M. K. Lim, and M. S.H. Ko Construction of Long-Transcript Enriched cDNA Libraries from Submicrogram Amounts of Total RNAs by a Universal PCR Amplification Method Genome Res., September 1, 2001; 11(9): 1553 - 1558. [Abstract] [Full Text] [PDF]

				J.L. Stanton and D.P.L. Green Meta-analysis of gene expression in mouse preimplantation embryo development Mol. Hum. Reprod., June 1, 2001; 7(6): 545 - 552. [Abstract] [Full Text] [PDF]

				J. Ma, P. Svoboda, R. M. Schultz, and P. Stein Regulation of Zygotic Gene Activation in the Preimplantation Mouse Embryo: Global Activation and Repression of Gene Expression Biol Reprod, June 1, 2001; 64(6): 1713 - 1721. [Abstract] [Full Text]

				M. D. Wilson, C. Riemer, D. W. Martindale, P. Schnupf, A. P. Boright, T. L. Cheung, D. M. Hardy, S. Schwartz, S. W. Scherer, L.-C. Tsui, et al. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5 Nucleic Acids Res., March 15, 2001; 29(6): 1352 - 1365. [Abstract] [Full Text] [PDF]

				T. S. Tanaka, S. A. Jaradat, M. K. Lim, G. J. Kargul, X. Wang, M. J. Grahovac, S. Pantano, Y. Sano, Y. Piao, R. Nagaraja, et al. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray PNAS, August 1, 2000; 97(16): 9127 - 9132. [Abstract] [Full Text] [PDF]

				G. J. Kargul, R. Nagaraja, T. Shimada, M. J. Grahovac, M. K. Lim, H. Nakashima, P. Waeltz, P. Ma, E. Chen, D. Schlessinger, et al. Eleven Densely Clustered Genes, Six of them Novel, in 176 kb of Mouse t-complex DNA Genome Res., July 1, 2000; 10(7): 916 - 923. [Abstract] [Full Text]