|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 9 1799-1813, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
A Camus, BP Davidson, S Billiards, P Khoo, JA Rivera-Perez, M Wakamiya, RR Behringer and PP Tam
Embryology Unit, Children's Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia. ptam@cmri.usyd.edu.au
The anterior midline tissue (AML) of the late gastrula mouse embryo comprises the axial mesendoderm and the ventral neuroectoderm of the prospective forebrain, midbrain and rostral hindbrain. In this study, we have investigated the morphogenetic role of defined segments of the AML by testing their inductive and patterning activity and by assessing the impact of their ablation on the patterning of the neural tube at the early-somite-stage. Both rostral and caudal segments of the AML were found to induce neural gene activity in the host tissue; however, the de novo gene activity did not show any regional characteristic that might be correlated with the segmental origin of the AML. Removal of the rostral AML that contains the prechordal plate resulted in a truncation of the head accompanied by the loss of several forebrain markers. However, the remaining tissues reconstituted Gsc and Shh activity and expressed the ventral forebrain marker Nkx2.1. Furthermore, analysis of Gsc-deficient embryos reveals that the morphogenetic function of the rostral AML requires Gsc activity. Removal of the caudal AML led to a complete loss of midline molecular markers anterior to the 4th somite. In addition, Nkx2.1 expression was not detected in the ventral neural tube. The maintenance and function of the rostral AML therefore require inductive signals emanating from the caudal AML. Our results point to a role for AML in the refinement of the anteroposterior patterning and morphogenesis of the brain.
This article has been cited by other articles:
|
|
 |
|
  S. L. Lewis, P.-L. Khoo, R. A. De Young, K. Steiner, C. Wilcock, M. Mukhopadhyay, H. Westphal, R. V. Jamieson, L. Robb, and P. P. L. Tam Dkk1 and Wnt3 interact to control head morphogenesis in the mouse Development, May 15, 2008; 135(10): 1791 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nishioka, S. Nagano, R. Nakayama, H. Kiyonari, T. Ijiri, K. Taniguchi, W. Shawlot, Y. Hayashizaki, H. Westphal, R. R. Behringer, et al. Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex Development, June 1, 2005; 132(11): 2535 - 2546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rhinn, K. Lun, M. Luz, M. Werner, and M. Brand Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling Development, March 15, 2005; 132(6): 1261 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kapsimali, L. Caneparo, C. Houart, and S. W. Wilson Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity Development, December 1, 2004; 131(23): 5923 - 5933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Rana, J. P. M. Barbera, T. A. Rodriguez, D. Lynch, E. Hirst, J. C. Smith, and R. S. P. Beddington Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates Development, October 15, 2004; 131(20): 4999 - 5007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Dunn, S. D. Vincent, L. Oxburgh, E. J. Robertson, and E. K. Bikoff Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo Development, April 15, 2004; 131(8): 1717 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Zoltewicz, N. J. Stewart, R. Leung, and A. S. Peterson Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis Development, January 1, 2004; 131(1): 3 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. del Barco Barrantes, G. Davidson, H.-J. Grone, H. Westphal, and C. Niehrs Dkk1 and noggin cooperate in mammalian head induction Genes & Dev., September 15, 2003; 17(18): 2239 - 2244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Halilagic, M. H. Zile, and M. Studer A novel role for retinoids in patterning the avian forebrain during presomite stages Development, May 15, 2003; 130(10): 2039 - 2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, Y. Liang, W. Deng, K. Shimizu, A. M. Ashique, E. Li, and Y.-P. Li The zinc-finger protein CNBP is required for forebrain formation in the mouse Development, April 1, 2003; 130(7): 1367 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. V. Lagutin, C. C. Zhu, D. Kobayashi, J. Topczewski, K. Shimamura, L. Puelles, H. R.C. Russell, P. J. McKinnon, L. Solnica-Krezel, and G. Oliver Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development Genes & Dev., February 1, 2003; 17(3): 368 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Roberts, H. F. Sutherland, H. Farmer, W. Kimber, S. Halford, A. Carey, J. M. Brickman, A. Wynshaw-Boris, and P. J. Scambler Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality Mol. Cell. Biol., April 1, 2002; 22(7): 2318 - 2328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Anderson, A. R. Lawrence, R. W. Stottmann, D. Bachiller, and J. Klingensmith Chordin and noggin promote organizing centers of forebrain development in the mouse Development, January 11, 2002; 129(21): 4975 - 4987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Page Inductive patterning of the embryonic brain in Drosophila Development, January 5, 2002; 129(9): 2121 - 2128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. H. Li and A. L. Joyner Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression Development, December 15, 2001; 128(24): 4979 - 4991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tallafu{beta}, T. P. Wilm, M. Crozatier, P. Pfeffer, M. Wassef, and L. Bally-Cuif The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development Development, October 15, 2001; 128(20): 4021 - 4034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Kinder, T. E. Tsang, M. Wakamiya, H. Sasaki, R. R. Behringer, A. Nagy, and P. P. L. Tam The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm Development, September 15, 2001; 128(18): 3623 - 3634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lowe, S Yamada, and M. Kuehn Genetic dissection of nodal function in patterning the mouse embryo Development, January 5, 2001; 128(10): 1831 - 1843. [Abstract] [PDF]
|
|
|
|
|
|
A Perea-Gomez, K. Lawson, M Rhinn, L Zakin, P Brulet, S Mazan, and S. Ang Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo Development, January 3, 2001; 128(5): 753 - 765. [Abstract] [PDF]
|
|
