spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fritz, J. L.
Right arrow Articles by VanBerkum, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fritz, J. L.
Right arrow Articles by VanBerkum, M. F.

Development, Vol 127, Issue 9 1991-2000, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS

JL Fritz and MF VanBerkum
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.

The establishment of axon trajectories is ultimately determined by the integration of intracellular signaling pathways. Here, a genetic approach in Drosophila has demonstrated that both Calmodulin and Son of sevenless signaling pathways are used to regulate which axons cross the midline. A loss in either signaling pathway leads to abnormal projection of axons across the midline and these increase with roundabout or slit mutations. When both Calmodulin and Son of sevenless are disrupted, the midline crossing of axons mimics that seen in roundabout mutants, although Roundabout remains expressed on crossing axons. Calmodulin and Son of sevenless also regulate axon crossing in a commissureless mutant. These data suggest that Calmodulin and Son of sevenless signaling pathways function to interpret midline repulsive cues which prevent axons crossing the midline.


This article has been cited by other articles:


Home page
 GeneticsHome page
K. M. Bhat, I. Gaziova, and S. Krishnan
Regulation of Axon Guidance by Slit and Netrin Signaling in the Drosophila Ventral Nerve Cord
Genetics, August 1, 2007; 176(4): 2235 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Hu, M. Li, J.-P. Labrador, J. McEwen, E. C. Lai, C. S. Goodman, and G. J. Bashaw
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion
PNAS, March 22, 2005; 102(12): 4613 - 4618.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Kinrade, T Brates, G Tear, and A Hidalgo
Roundabout signalling, cell contact and trophic support confine longitudinal glia and axons in the Drosophila CNS
Development, January 1, 2001; 128(2): 207 - 216.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
A. Scherer and J. M. Graff
Calmodulin Differentially Modulates Smad1 and Smad2 Signaling
J. Biol. Chem., December 22, 2000; 275(52): 41430 - 41438.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000