spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, G.
Right arrow Articles by Alexander, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, G.
Right arrow Articles by Alexander, H.
Development 128, 3473-3483 (2001)
© 2001 The Company of Biologists Limited

Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum

Guochun Li*,§, Christopher Foote*, Stephen Alexander and Hannah Alexander{ddagger}

§ Present address: Department of Biology, University of California, San Diego, LaJolla, CA 92093-0568, USA
Division of Biological Sciences, University of Missouri, Columbia, MO 65211-7400, USA
* These authors contributed equally to this study

{ddagger}Author for correspondence (e-mail: alexanderh{at}missouri.edu)

Accepted June 20, 2001

Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development.

Key words: Cisplatin resistance, Sphingolipids, Cell motility, Morphogenesis, Gene expression, Actin, Pseudopodia, EDG receptors, G proteins, GPI anchor, Dictyostelium discoideum




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M. L. Allende, T. Sasaki, H. Kawai, A. Olivera, Y. Mi, G. van Echten-Deckert, R. Hajdu, M. Rosenbach, C. A. Keohane, S. Mandala, et al.
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
J. Biol. Chem., December 10, 2004; 279(50): 52487 - 52492.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. D. Saba and T. Hla
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
Circ. Res., April 2, 2004; 94(6): 724 - 734.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Mendel, K. Heinecke, H. Fyrst, and J. D. Saba
Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans
J. Biol. Chem., June 13, 2003; 278(25): 22341 - 22349.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
T. Hla, M.-J. Lee, N. Ancellin, J. H. Paik, and M. J. Kluk
Lysophospholipids--Receptor Revelations
Science, November 30, 2001; 294(5548): 1875 - 1878.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2001