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1 Division of Early Embryogenesis, National Institute of Genetics, Mishima, 411-8540 Japan
2 Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan
3 Vertebrate Development Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
* Present address: Department of Biological Sciences, Graduate School of Science, The University of Tokyo. Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
Author for correspondence (e-mail: htakeda{at}biol.s.u-tokyo.ac.jp)
Accepted August 29, 2001
The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.
Key words: Fgf, Somite, Segmentation, Tailbud, fused somites, after eight, her1, Zebrafish
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