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Development, Vol 128, Issue 3 331-339, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
B Estrada and E Sanchez-Herrero
Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain.
In Drosophila, the Hox gene Abdominal-B is required to specify the posterior abdomen and the genitalia. Homologues of Abdominal-B in other species are also needed to determine the posterior part of the body. We have studied the function of Abdominal-B in the formation of Drosophila genitalia, and show here that absence of Abdominal-B in the genital disc of Drosophila transforms male and female genitalia into leg or, less frequently, into antenna. These transformations are accompanied by the ectopic expression of genes such as Distal-less or dachshund, which are normally required in these appendages. The extent of wild-type and ectopic Distal-less expression depends on the antagonistic activities of the Abdominal-B gene, as a repressor, and of the decapentaplegic and wingless genes as activators. Absence of Abdominal-B also changes the expression of Homothorax, a Hox gene co-factor. Our results suggest that Abdominal-B forms genitalia by modifying an underlying positional information and repressing appendage development. We propose that the genital primordia should be subdivided into two regions, one of them competent to be transformed into an appendage in the absence of Abdominal-B.
This article has been cited by other articles:
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  L. F. de Navas, D. L. Garaulet, and E. Sanchez-Herrero The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway Development, November 15, 2006; 133(22): 4495 - 4506. [Abstract] [Full Text] [PDF]
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D. Foronda, B. Estrada, L. de Navas, and E. Sanchez-Herrero Requirement of abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule Development, January 1, 2006; 133(1): 117 - 127. [Abstract] [Full Text] [PDF]
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B. Estrada, F. Casares, A. Busturia, and E. Sanchez-Herrero Genetic and molecular characterization of a novel iab-8 regulatory domain in the Abdominal-B gene of Drosophila melanogaster Development, March 13, 2003; 129(22): 5195 - 5204. [Abstract] [Full Text] [PDF]
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N. Gorfinkiel, L. Sanchez, and I. Guerrero Development of the Drosophila genital disc requires interactions between its segmental primordia Development, March 2, 2003; 130(2): 295 - 305. [Abstract] [Full Text] [PDF]
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 R. Lints and S. W. Emmons Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family Genes & Dev., September 15, 2002; 16(18): 2390 - 2402. [Abstract] [Full Text] [PDF]
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Y. Shiga, R. Yasumoto, H. Yamagata, and S. Hayashi Evolving role of Antennapedia protein in arthropod limb patterning Development, August 1, 2002; 129(15): 3555 - 3561. [Abstract] [Full Text] [PDF]
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 F. Casares and R. S. Mann The Ground State of the Ventral Appendage in Drosophila Science, August 24, 2001; 293(5534): 1477 - 1480. [Abstract] [Full Text] [PDF]
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L Sanchez, N Gorfinkiel, and I Guerrero Sex determination genes control the development of the Drosophila genital disc, modulating the response to Hedgehog, Wingless and Decapentaplegic signals Development, January 4, 2001; 128(7): 1033 - 1043. [Abstract] [PDF]
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