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Development, Vol 128, Issue 3 341-351, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
Y Cinnamon, N Kahane, I Bachelet and C Kalcheim
Department of Anatomy and Cell Biology, Hebrew University-Hadassah Medical School, Jerusalem 91120, PO Box 12272, Israel.
We have previously reported that the myotome is formed by a first wave of pioneer cells generated from all along the dorsomedial portion of the epithelial somite and a second wave of cells issued from all four edges of the dermomyotome. Cells from the extreme rostral and caudal edges directly generate myofibers that elongate towards the opposite pole of each segment and along the pre-existing myotomal scaffold. In contrast, cells from the dorsomedial and ventrolateral lips first reach the extreme edges and then contribute to myofiber formation. The mechanism by which these epithelial cells translocate remained unknown and was the goal of the present study. We have found that epithelial cells along the dorsomedial and ventrolateral lips of the dermomyotome first delaminate into the immediate underlayer of the corresponding lips, the sub-lip domain, then migrate longitudinally along this pathway until reaching the extreme edges from which they differentiate into myofibers. Cells of the sub-lip domain are negative for Pax3 and desmin but express MyoD, Myf5 and FREK, suggesting that they are specific myogenic progenitors.
This article has been cited by other articles:
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  Y. Cinnamon, R. Ben-Yair, and C. Kalcheim Differential effects of N-cadherin-mediated adhesion on the development of myotomal waves Development, March 15, 2006; 133(6): 1101 - 1112. [Abstract] [Full Text] [PDF]
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R. Ben-Yair and C. Kalcheim Lineage analysis of the avian dermomyotome sheet reveals the existence of single cells with both dermal and muscle progenitor fates Development, February 15, 2005; 132(4): 689 - 701. [Abstract] [Full Text] [PDF]
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M.-C. Delfini and D. Duprez Ectopic Myf5 or MyoD prevents the neuronal differentiation program in addition to inducing skeletal muscle differentiation, in the chick neural tube Development, February 15, 2004; 131(4): 713 - 723. [Abstract] [Full Text] [PDF]
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R. Ben-Yair, N. Kahane, and C. Kalcheim Coherent development of dermomyotome and dermis from the entire mediolateral extent of the dorsal somite Development, September 15, 2003; 130(18): 4325 - 4336. [Abstract] [Full Text] [PDF]
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L. D. Sacks, G. M. Cann, W. Nikovits Jr, S. Conlon, N. R. Espinoza, and F. E. Stockdale Regulation of myosin expression during myotome formation Development, August 1, 2003; 130(15): 3391 - 3402. [Abstract] [Full Text] [PDF]
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I. Olivera-Martinez, S. Missier, S. Fraboulet, J. Thelu, and D. Dhouailly Differential regulation of the chick dorsal thoracic dermal progenitors from the medial dermomyotome Development, March 12, 2003; 129(20): 4763 - 4772. [Abstract] [Full Text] [PDF]
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L. Teboul, J. Hadchouel, P. Daubas, D. Summerbell, M. Buckingham, and P. W. J. Rigby The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis Development, January 10, 2002; 129(19): 4571 - 4580. [Abstract] [Full Text] [PDF]
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N. Kahane, Y. Cinnamon, and C. Kalcheim The roles of cell migration and myofiber intercalation in patterning formation of the postmitotic myotome Development, January 6, 2002; 129(11): 2675 - 2687. [Abstract] [Full Text] [PDF]
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R. C. Mootoosamy and S. Dietrich Distinct regulatory cascades for head and trunk myogenesis Development, January 2, 2002; 129(3): 573 - 583. [Abstract] [Full Text] [PDF]
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S. Eloy-Trinquet and J.-F. Nicolas Clonal separation and regionalisation during formation of the medial and lateral myotomes in the mouse embryo Development, January 1, 2002; 129(1): 111 - 122. [Abstract] [Full Text] [PDF]
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N. Kahane, Y. Cinnamon, I. Bachelet, and C. Kalcheim The third wave of myotome colonization by mitotically competent progenitors: regulating the balance between differentiation and proliferation during muscle development Development, June 15, 2001; 128(12): 2187 - 2198. [Abstract] [Full Text] [PDF]
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