|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 128, Issue 3 417-426, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
WY Kim, B Fritzsch, A Serls, LA Bakel, EJ Huang, LF Reichardt, DS Barth and JE Lee
Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
A key factor in the genetically programmed development of the nervous system is the death of massive numbers of neurons. Therefore, genetic mechanisms governing cell survival are of fundamental importance to developmental neuroscience. We report that inner ear sensory neurons are dependent on a basic helix-loop-helix transcription factor called NeuroD for survival during differentiation. Mice lacking NeuroD protein exhibit no auditory evoked potentials, reflecting a profound deafness. DiI fiber staining, immunostaining and cell death assays reveal that the deafness is due to the failure of inner ear sensory neuron survival during development. The affected inner ear sensory neurons fail to express neurotrophin receptors, TrkB and TrkC, suggesting that the ability of NeuroD to support neuronal survival may be directly mediated through regulation of responsiveness to the neurotrophins.
This article has been cited by other articles:
|
|
 |
|
  E. R. Neptune, M. Podowski, C. Calvi, J.-H. Cho, J. G. N. Garcia, R. Tuder, R. I. Linnoila, M.-J. Tsai, and H. C. Dietz Targeted Disruption of NeuroD, a Proneural Basic Helix-Loop-Helix Factor, Impairs Distal Lung Formation and Neuroendocrine Morphology in the Neonatal Lung J. Biol. Chem., July 25, 2008; 283(30): 21160 - 21169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Koundakjian, J. L. Appler, and L. V. Goodrich Auditory Neurons Make Stereotyped Wiring Decisions before Maturation of Their Targets J. Neurosci., December 19, 2007; 27(51): 14078 - 14088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Coleman, M. G. de Silva, and R. K. Shepherd Concise Review: The Potential of Stem Cells for Auditory Neuron Generation and Replacement Stem Cells, November 1, 2007; 25(11): 2685 - 2694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Wanner and J. R. Miller Regulation of otic vesicle and hair cell stereocilia morphogenesis by Ena/VASP-like (Evl) in Xenopus J. Cell Sci., August 1, 2007; 120(15): 2641 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Daudet, L. Ariza-McNaughton, and J. Lewis Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear Development, June 15, 2007; 134(12): 2369 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhao, C. Johansson, T. Tran, R. Bettencourt, Y. Itahana, P.-Y. Desprez, and S. F. Konieczny Identification of a Basic Helix-Loop-Helix Transcription Factor Expressed in Mammary Gland Alveolar Cells and Required for Maintenance of the Differentiated State Mol. Endocrinol., September 1, 2006; 20(9): 2187 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takeshita, R. Fujinaga, C. Zhao, A. Yanai, and K. Shinoda Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis Hum. Mol. Genet., August 1, 2006; 15(15): 2298 - 2312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chu and M.-J. Tsai Neuronatin, a Downstream Target of BETA2/NeuroD1 in the Pancreas, Is Involved in Glucose-Mediated Insulin Secretion Diabetes, April 1, 2005; 54(4): 1064 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Lay, G. Bane, C. S. Brunkan, J. Davis, L. Lopez-Diaz, and L. C. Samuelson Enteroendocrine cell expression of a cholecystokinin gene construct in transgenic mice and cultured cells Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G354 - G361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zou, D. Silvius, B. Fritzsch, and P.-X. Xu Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes Development, November 15, 2004; 131(22): 5561 - 5572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Barald and M. W. Kelley From placode to polarization: new tunes in inner ear development Development, September 1, 2004; 131(17): 4119 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Raft, S. Nowotschin, J. Liao, and B. E. Morrow Suppression of neural fate and control of inner ear morphogenesis by Tbx1 Development, April 15, 2004; 131(8): 1801 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, M. Encinas, J. X. Comella, M. Aldea, and C. Gallego Basic Helix-Loop-Helix Proteins Bind to TrkB and p21Cip1 Promoters Linking Differentiation and Cell Cycle Arrest in Neuroblastoma Cells Mol. Cell. Biol., April 1, 2004; 24(7): 2662 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Kim, K. Chu, H.-J. Kim, H.-A Seong, K.-C. Park, S. Sanyal, J. Takeda, H. Ha, M. Shong, M.-J. Tsai, et al. Orphan Nuclear Receptor Small Heterodimer Partner, a Novel Corepressor for a Basic Helix-Loop-Helix Transcription Factor BETA2/NeuroD Mol. Endocrinol., April 1, 2004; 18(4): 776 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, L. Huang, Z.-B. Wei, D. Silvius, B. Tang, and P.-X. Xu The role of Six1 in mammalian auditory system development Development, September 1, 2003; 130(17): 3989 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Marcora, K. Gowan, and J. E. Lee Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 PNAS, August 5, 2003; 100(16): 9578 - 9583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Inoue, M. Hojo, Y. Bessho, Y. Tano, J. E. Lee, and R. Kageyama Math3 and NeuroD regulate amacrine cell fate specification in the retina Development, March 4, 2003; 129(4): 831 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Moates, S. Nanda, M. A. Cissell, M.-J. Tsai, and R. Stein BETA2 Activates Transcription From the Upstream Glucokinase Gene Promoter in Islet {beta}-Cells and Gut Endocrine Cells Diabetes, February 1, 2003; 52(2): 403 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Pennesi, J.-H. Cho, Z. Yang, S. H. Wu, J. Zhang, S. M. Wu, and M.-J. Tsai BETA2/NeuroD1 Null Mice: A New Model for Transcription Factor-Dependent Photoreceptor Degeneration J. Neurosci., January 15, 2003; 23(2): 453 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Wasserman, F. Mehraban, L. G. Komuves, R.-B. Yang, J. E. Tomlinson, Y. Zhang, F. Spriggs, and J. N. Topper Gene expression profile of human endothelial cells exposed to sustained fluid shear stress Physiol Genomics, December 26, 2002; 12(1): 13 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Riccomagno, L. Martinu, M. Mulheisen, D. K. Wu, and D. J. Epstein Specification of the mammalian cochlea is dependent on Sonic hedgehog Genes & Dev., September 15, 2002; 16(18): 2365 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Farinas, K. R. Jones, L. Tessarollo, A. J. Vigers, E. Huang, M. Kirstein, D. C. de Caprona, V. Coppola, C. Backus, L. F. Reichardt, et al. Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression J. Neurosci., August 15, 2001; 21(16): 6170 - 6180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, C. Lin, A. Gleiberman, K. A. Ohgi, T. Herman, H.-P. Huang, M.-J. Tsai, and M. G. Rosenfeld Tbx19, a tissue-selective regulator of POMC gene expression PNAS, July 5, 2001; (2001) 141234898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Huang, W. Liu, B. Fritzsch, L. M. Bianchi, L. F. Reichardt, and M. Xiang Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons Development, July 1, 2001; 128(13): 2421 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, C. Lin, A. Gleiberman, K. A. Ohgi, T. Herman, H.-P. Huang, M.-J. Tsai, and M. G. Rosenfeld Tbx19, a tissue-selective regulator of POMC gene expression PNAS, July 17, 2001; 98(15): 8674 - 8679. [Abstract] [Full Text] [PDF]
|
|
