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Development 129, 133-141 (2002)
© 2002 The Company of Biologists Limited

myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila

Mar Ruiz-Gómez1, Nikola Coutts2, Maximiliano L. Suster2, Matthias Landgraf2 and Michael Bate2,*

1 Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
2 Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK

*Author for correspondence (e-mail: cmb16{at}cus.cam.ac.uk)

Accepted 12 October 2001

We report a new gene, myoblasts incompetent, essential for normal myogenesis and myoblast fusion in Drosophila. myoblasts incompetent encodes a putative zinc finger transcription factor related to vertebrate Gli proteins and to Drosophila Cubitus interruptus. myoblasts incompetent is expressed in immature somatic and visceral myoblasts. Expression is predominantly in fusion-competent myoblasts and a loss-of-function mutation in myoblasts incompetent leads to a failure in the normal differentiation of these cells and a complete lack of myoblast fusion. In the mutant embryos, founder myoblasts differentiate normally and form mononucleate muscles, but genes that are specifically expressed in fusion-competent cells are not activated and the normal downregulation of twist expression in these cells fails to occur. In addition, fusion-competent myoblasts fail to express proteins characteristic of the general pathway of myogenesis such as myosin and Dmef2. Thus myoblasts incompetent appears to function specifically in the general pathway of myogenesis to control the differentiation of fusion-competent myoblasts.

Key words: Drosophila, Myoblasts, Cell fusion, Myogenesis, Transcription factor, myoblasts incompetent




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© The Company of Biologists Ltd 2002