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Development 129, 2411-2418 (2002)
© 2002 The Company of Biologists Limited

Repression of Teashirt marks the initiation of wing development

Jun Wu* and Stephen M. Cohen{dagger}

Developmental Biology program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
* Present address: Mount Sinai School of Medicine, 1 Gustav Levy Place, New York, NY, USA

{dagger}Author for correspondence (email: cohen{at}embl-heidelberg.de)

Accepted 26 February 2002

The wing imaginal disc comprises the primordia of the adult wing and the dorsal thoracic body wall. During second larval instar, the wing disc is subdivided into distinct domains that correspond to the presumptive wing and body wall. Early activity of the signaling protein Wingless has been implicated in the specification of the wing primordium. Wingless mutants can produce animals in which the wing is replaced by a duplication of thoracic structures. Specification of wing fate has been visualized by expression of the POU-homeodomain protein Nubbin in the presumptive wing territory and by repression of the homeodomain protein Homothorax. We report that repression of the zinc-finger transcription factor Teashirt (Tsh) is the earliest event in wing specification. Repression of Tsh by the combined action of Wingless and Decapentaplegic is required for wing pouch formation and for subsequent repression of Hth. Thus, repression of Tsh defines the presumptive wing earlier in development than repression of Hth, which must therefore be considered a secondary event.

Key words: Imaginal disc, Teashirt, Homothorax, Wing, Pattern formation, Drosophila melanogaster




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© The Company of Biologists Ltd 2002