QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Latimer, A. J. Articles by Appel, B. Search for Related Content PubMed PubMed Citation Articles by Latimer, A. J. Articles by Appel, B.

Delta-Notch signaling induces hypochord development in zebrafish

Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA

*Author for correspondence (e-mail: b.appel{at}vanderbilt.edu)

Accepted 15 March 2002

Different cell types that occupy the midline of vertebrate embryos originate within the Spemann-Mangold or gastrula organizer. One such cell type is hypochord, which lies ventral to notochord in anamniote embryos. We show that hypochord precursors arise from the lateral edges of the organizer in zebrafish. During gastrulation, hypochord precursors are closely associated with no tail-expressing midline precursors and paraxial mesoderm, which expresses deltaC and deltaD. Loss-of-function experiments revealed that deltaC and deltaD were required for her4 expression in presumptive hypochord precursors and for hypochord development. Conversely, ectopic, unregulated Notch activity blocked no tail expression and promoted her4 expression. We propose that Delta signaling from paraxial mesoderm diversifies midline cell fate by inducing a subset of neighboring midline precursors to develop as hypochord, rather than as notochord.

Key words: Delta, Notch, Notochord, Hypochord, Midline, Fate map, Zebrafish, Gastrulation

This article has been cited by other articles:

				H. Huang, H. Ruan, M. Y. Aw, A. Hussain, L. Guo, C. Gao, F. Qian, T. Leung, H. Song, D. Kimelman, et al. Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis Development, October 1, 2008; 135(19): 3209 - 3218. [Abstract] [Full Text] [PDF]

				F. Galis and J. A. J. Metz Evolutionary novelties: the making and breaking of pleiotropic constraints Integr. Comp. Biol., September 1, 2007; 47(3): 409 - 419. [Abstract] [Full Text] [PDF]

				S. L. Lopez, M. V. Rosato-Siri, P. G. Franco, A. R. Paganelli, and A. E. Carrasco The Notch-target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos Development, March 1, 2005; 132(5): 1035 - 1046. [Abstract] [Full Text] [PDF]

				G. J. Wright, J. D. Leslie, L. Ariza-McNaughton, and J. Lewis Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development Development, November 15, 2004; 131(22): 5659 - 5669. [Abstract] [Full Text] [PDF]

				S. L. Lopez, A. R. Paganelli, M. V. R. Siri, O. H. Ocana, P. G. Franco, and A. E. Carrasco Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates in Xenopus Development, May 15, 2003; 130(10): 2225 - 2238. [Abstract] [Full Text] [PDF]

				G. K. H. Przemeck, U. Heinzmann, J. Beckers, and M. Hrabe de Angelis Node and midline defects are associated with left-right development in Delta1 mutant embryos Development, January 1, 2003; 130(1): 3 - 13. [Abstract] [Full Text] [PDF]