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1 Centro de Biología Molecular-Severo Ochoa/C.S.I.C., Facultad de Ciencias-CV, Universidad Autónoma-Cantoblanco, 28049 Madrid, Spain
2 School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
*Author for correspondence (e-mail: diazbenjumea{at}cbm.uam.es)
Accepted 6 June 2002
The Drosophila gene wingless encodes a secreted signalling molecule that is required for many patterning events in both embryonic and postembryonic development. In the wing wingless is expressed in a complex and dynamic pattern that is controlled by several different mechanisms. These involve the Hedgehog and Notch pathways and the nuclear proteins Pannier and U-shaped. In this report, we analyse the mechanisms that drive wingless expression in the wing hinge. We present evidence that wingless is initially activated by a secreted signal that requires the genes vestigial, rotund and nubbin. Later in development, wingless expression in the wing hinge is maintained by a different mechanism, which involves an autoregulatory loop and requires the genes homothorax and rotund. We discuss the role of wingless in patterning the wing hinge.
Key words: Drosophila, Pattern formation, wingless, Wing hinge
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