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Development 129, 4435-4442 (2002)
© 2002 The Company of Biologists Limited

BMP signaling is required for development of the ciliary body

Shulei Zhao1,*,{dagger}, Qin Chen1, Fang-Cheng Hung2 and Paul A. Overbeek1,2

1 Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
2 Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
* Present address: Lexicon Genetics, 8800 Technology Forest Place, The Woodlands, TX 77381, USA

{dagger}Author for correspondence (e-mail: szhao{at}lexgen.com)

Accepted 20 June 2002

The ciliary body in the eye secretes aqueous humor and glycoproteins of the vitreous body and maintains the intraocular pressure. The ciliary muscle controls the shape of the lens through the ciliary zonules to focus the image onto the retina. During embryonic development, the ciliary epithelium is derived from the optic vesicle, but the molecular signals that control morphogenesis of the ciliary body are unknown. We report that lens-specific expression of a transgenic protein, Noggin, can block BMP signaling in the mouse eye and result in failure in formation of the ciliary processes. Co-expression of transgenic BMP7 restores normal development of the ciliary epithelium. Ectopic expression of Noggin also promotes differentiation of retinal ganglion cells. These results indicate that BMP signaling is required for development of the ciliary body and may also play a role in regulation of neuronal differentiation in the developing eye.

Key words: Ciliary body, Eye, BMP4, BMP7, Noggin, Smad1, Msx1, Otx1, Mouse




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© The Company of Biologists Ltd 2002