spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, S.-H.
Right arrow Articles by Huh, T.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, S.-H.
Right arrow Articles by Huh, T.-L.
Development 129, 4443-4455 (2002)
© 2002 The Company of Biologists Limited

Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish

Seok-Hyung Kim1, Jimann Shin1, Hae-Chul Park1, Sang-Yeob Yeo1, Sung-Kook Hong1,2, Sangtae Han2, Myungchull Rhee3, Cheol-Hee Kim3, Ajay B. Chitnis4 and Tae-Lin Huh1,2,*

1 Department of Genetic Engineering, Kyungpook National University, Daegu 702-701, Korea
2 TG Biotech, KNU Technopark, Kyungpook National University, Daegu 702-701, Korea
3 Department of Biology, Chungnam National University, Daejeon 305-764, Korea
4 Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA

*Author for correspondence (e-mail: tlhuh{at}knu.ac.kr)

Accepted 25 June 2002

Wnts have been shown to provide a posteriorizing signal that has to be repressed in the anterior neuroectoderm for normal anteroposterior (AP) patterning. We have previously identified a zebrafish frizzled8a (fz8a) gene expressed in the presumptive anterior neuroectoderm as well as prechordal plate at the late gastrula stage. We have investigated the role of Fz8a-mediated Wnt8b signalling in anterior brain patterning in zebrafish. We show that in zebrafish embryos: (1) Wnt signalling has at least two different stage-specific posteriorizing activities in the anterior neuroectoderm, one before mid-gastrulation and the other at late gastrulation; (2) Fz8a plays an important role in mediating anterior brain patterning; (3) Wnt8b and Fz8a can functionally interact to transmit posteriorizing signals that determine the fate of the posterior diencephalon and midbrain in late gastrula embryos; and (4) Wnt8b can suppress fz8a expression in the anterior neuroectoderm and potentially affect the level and/or range of Wnt signalling. In conclusion, we suggest that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula.

Key words: Fz8a, Wnt8b, Anterior neuroectoderm, Brain patterning, Eye primordia, Diencephalon, Midbrain, Zebrafish




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Y. Miyasaka, Y. S. Kida, T. Sato, M. Minami, and T. Ogura
Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin
PNAS, July 3, 2007; 104(27): 11274 - 11279.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Hans and M. Westerfield
Changes in retinoic acid signaling alter otic patterning
Development, July 1, 2007; 134(13): 2449 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L. Caneparo, Y.-L. Huang, N. Staudt, M. Tada, R. Ahrendt, O. Kazanskaya, C. Niehrs, and C. Houart
Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/betacatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek
Genes & Dev., February 15, 2007; 21(4): 465 - 480.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Peng and M. Westerfield
Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists
Development, August 15, 2006; 133(16): 3191 - 3200.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Bellipanni, M. Varga, S. Maegawa, Y. Imai, C. Kelly, A. P. Myers, F. Chu, W. S. Talbot, and E. S. Weinberg
Essential and opposing roles of zebrafish {beta}-catenins in the formation of dorsal axial structures and neurectoderm
Development, April 1, 2006; 133(7): 1299 - 1309.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Croce, L. Duloquin, G. Lhomond, D. R. McClay, and C. Gache
Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development
Development, February 1, 2006; 133(3): 547 - 557.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kapsimali, L. Caneparo, C. Houart, and S. W. Wilson
Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity
Development, December 1, 2004; 131(23): 5923 - 5933.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. J. Thorpe and R. T. Moon
nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development
Development, June 15, 2004; 131(12): 2899 - 2909.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. I. Dorsky, M. Itoh, R. T. Moon, and A. Chitnis
Two tcf3 genes cooperate to pattern the zebrafish brain
Development, May 1, 2003; 130(9): 1937 - 1947.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002