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A combination of chain and neurophilic migration involving the adhesion molecule TAG-1 in the caudal medulla

Katerina Kyriakopoulou¹, Isabel de Diego^2,*, Marion Wassef² and Domna Karagogeos^1,

¹ Department of Basic Science, Medical School, University of Crete and Institute of Molecular Biology and Biotechnology, PO Box 1527, 711 10 Heraklion, Greece
² CNRS UMR 8542, Regionalisation Nerveuse, Ecole Normale Superieure, 46 rue d’Ulm 75230 Paris Cedex 5, France
^* Present address: Departamento de Biología Celular, Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos, 29071 Málaga, Spain

Author for correspondence (e-mail: karagoge{at}nefeli.imbb.forth.gr)

Accepted 17 October 2001

Neuronal populations destined to form several precerebellar nuclei are generated by the rhombic lip in the caudal hindbrain. These immature neurons gather into the olivary and the superficial migratory streams and migrate tangentially around the hindbrain to reach their final position. We focus on the cells of the superficial stream that migrate ventrally, cross the midline and form the lateral reticular (LRN) and external cuneate (ECN) nuclei. The cells of the superficial steam are preceded by long leading processes; in the dorsal neural tube, they migrate in close apposition to each other and form distinct chains, whereas they disperse and follow Tuj-1 immunoreactive axons on reaching the ventral hindbrain. This suggests that, in the superficial stream, neuronal migration combines both homotypic and heterotypic mechanisms. We also show that the adhesion molecule TAG-1 is expressed by the migrating cells. Blocking TAG-1 function results in alterations in the superficial migration, indicating that TAG-1 is involved in the superficial migration. Other members of the immunoglobulin superfamily and known ligands of TAG-1 are also expressed in the region of the migration but are not involved in the migration. These findings provide evidence that the TAG-1 protein is involved as a contact-dependent signal guiding not only axonal outgrowth but also cell migration.

Key words: Tangential migration, Precerebellar nuclei, LRN, ECN, TAG-1, IgSF, Medulla, Mouse

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