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Development 129, 4697-4705 (2002)
Copyright © 2002 The Company of Biologists Limited

Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro

Beatrix P. Rubin1,*, Richard P. Tucker2,*, Marianne Brown-Luedi1, Doris Martin1 and Ruth Chiquet-Ehrismann1,{dagger}

1 Friedrich Miescher Institute, Novartis Research Foundation, PO Box 2543, CH-4002 Basel, Switzerland
2 Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA
* These authors contributed equally to this work

{dagger}Author for correspondence (e-mail: chiquet{at}fmi.ch)

Accepted 20 June 2002

The transmembrane glycoprotein teneurin 2 is expressed by neurons in the developing avian thalamofugal visual system at periods that correspond with target recognition and synaptogenesis. Partial and full-length teneurin 2 constructs were expressed in cell lines in vitro. Expression of the cytoplasmic domain is required for the induction of filopodia, the transport of teneurin 2 into neurites and the co-localization of teneurin 2 with the cortical actin cytoskeleton. In addition, expression of the extracellular domain of teneurin 2 by HT1080 cells induced cell aggregation, and the extracellular domain of teneurin 2 became concentrated at sites of cell-cell contact in neuroblastoma cells. These observations indicate that the homophilic binding of teneurin 2 may play a role in the development of specific neuronal circuits in the developing visual system.

Key words: DOC4, Neurestin, Odz, Tenm, Tena, Ten-m, Chicken






© The Company of Biologists Ltd 2002