spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

doi: 10.1242/10.1242/dev.00096

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baonza, A.
Right arrow Articles by Freeman, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baonza, A.
Right arrow Articles by Freeman, M.
Development 129, 5313-5322 (2002)
Copyright © 2002 The Company of Biologists Limited

Control of Drosophila eye specification by Wingless signalling

Antonio Baonza and Matthew Freeman*

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

* Author for correspondence (e-mail: mf1{at}mrc-lmb.cam.ac.uk)

Accepted 15 August 2002

Organ formation requires early specification of the groups of cells that will give rise to specific structures. The Wingless protein plays an important part in this regional specification of imaginal structures in Drosophila, including defining the region of the eye-antennal disc that will become retina. We show that Wingless signalling establishes the border between the retina and adjacent head structures by inhibiting the expression of the eye specification genes eyes absent, sine oculis and dachshund. Ectopic Wingless signalling leads to the repression of these genes and the loss of eyes, whereas loss of Wingless signalling has the opposite effects. Wingless expression in the anterior of wild-type discs is complementary to that of these eye specification genes. Contrary to previous reports, we find that under conditions of excess Wingless signalling, eye tissue is transformed not only into head cuticle but also into a variety of inappropriate structures.

Key words: Drosophila, Wingless, Axin, Eyes absent, Sine oculis, Dachshund, Eye, Transdetermination, Transdifferentiation




This article has been cited by other articles:


Home page
 DevelopmentHome page
L. A. Ekas, G.-H. Baeg, M. S. Flaherty, A. Ayala-Camargo, and E. A. Bach
JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila
Development, December 1, 2006; 133(23): 4721 - 4729.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S.-H. Cho and C. L. Cepko
Wnt2b/{beta}-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye
Development, August 15, 2006; 133(16): 3167 - 3177.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Bessa and F. Casares
Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila
Development, November 15, 2005; 132(22): 5011 - 5020.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Katsuyama, T. Sugawara, M. Tatsumi, Y. Oshima, W. J. Gehring, T. Aigaki, and S. Kurata
Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification
PNAS, November 1, 2005; 102(44): 15918 - 15923.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. S. Pappu, E. J. Ostrin, B. W. Middlebrooks, B. T. Sili, R. Chen, M. R. Atkins, R. Gibbs, and G. Mardon
Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund
Development, June 15, 2005; 132(12): 2895 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. J. Silver and I. Rebay
Signaling circuitries in development: insights from the retinal determination gene network
Development, January 1, 2005; 132(1): 3 - 13.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. P. Kumar, T. Jamal, A. Doetsch, F. R. Turner, and J. B. Duffy
CREB Binding Protein Functions During Successive Stages of Eye Development in Drosophila
Genetics, October 1, 2004; 168(2): 877 - 893.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. Thomas and P. W. Ingham
Hedgehog Signaling in the Drosophila Eye and Head: An Analysis of the Effects of Different patched Trans-heterozygotes
Genetics, December 1, 2003; 165(4): 1915 - 1928.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. J. Silver, E. L. Davies, L. Doyon, and I. Rebay
Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network
Mol. Cell. Biol., September 1, 2003; 23(17): 5989 - 5999.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
M. Friedrich
Evolution of Insect Eye Development: First Insights from Fruit Fly, Grasshopper and Flour Beetle
Integr. Comp. Biol., August 1, 2003; 43(4): 508 - 521.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun
Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development
Development, July 1, 2003; 130(13): 2939 - 2951.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002