|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
doi: 10.1242/10.1242/dev.00448
1 Section on Developmental Neuroscience, NIDCD, National Institutes of Health,
Rockville, MD 20850, USA
2 Department of Biological Sciences, Imperial College of Science, Technology and
Medicine, Exhibition Road, London SW7 2AZ, UK
3 Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, NCI,
National Institutes of Health, Bethesda, MD 20892, USA
4 Department of Biochemistry and Molecular Biology, Mount Sinai School of
Medicine, New York, NY 10029, USA
5 Department of Biochemistry and Cell Biology, State University of New York at
Stony Brook, Stony Brook, NY 11794, USA
* Author for correspondence (e-mail: dabdouba{at}nidcd.nih.gov)
Accepted 11 February 2003
In the mammalian cochlea, stereociliary bundles located on mechanosensory hair cells within the sensory epithelium are unidirectionally oriented. Development of this planar polarity is necessary for normal hearing as stereociliary bundles are only sensitive to vibrations in a single plane; however, the mechanisms governing their orientation are unknown. We report that Wnt signaling regulates the development of unidirectional stereociliary bundle orientation. In vitro application of Wnt7a protein or inhibitors of Wnt signaling, secreted Frizzled-related protein 1 or Wnt inhibitory factor 1, disrupts bundle orientation. Moreover, Wnt7a is expressed in a pattern consistent with a role in the polarization of the developing stereociliary bundles. We propose that Wnt signaling across the region of developing outer hair cells gives rise to planar polarity in the mammalian cochlea.
Key words: Planar polarity, Organ of Corti, Sensory epithelium, Mechanosensory hair cells, Mouse
Related articles in Development:
This article has been cited by other articles:
|
|
 |
|
  R. van Amerongen, A. Mikels, and R. Nusse Alternative Wnt Signaling Is Initiated by Distinct Receptors Sci. Signal., September 2, 2008; 1(35): re9 - re9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lefevre, V. Michel, D. Weil, L. Lepelletier, E. Bizard, U. Wolfrum, J.-P. Hardelin, and C. Petit A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth Development, April 15, 2008; 135(8): 1427 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Cerpa, J. A. Godoy, I. Alfaro, G. G. Farias, M. J. Metcalfe, R. Fuentealba, C. Bonansco, and N. C. Inestrosa Wnt-7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons J. Biol. Chem., February 29, 2008; 283(9): 5918 - 5927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Rawls, S. A. Schultz, R. D. Mitra, and T. Wolff Bedraggled, a Putative Transporter, Influences the Tissue Polarity Complex During the R3/R4 Fate Decision in the Drosophila Eye Genetics, September 1, 2007; 177(1): 313 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Sajan, M. E. Warchol, and M. Lovett Toward a Systems Biology of Mouse Inner Ear Organogenesis: Gene Expression Pathways, Patterns and Network Analysis Genetics, September 1, 2007; 177(1): 631 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Deans, D. Antic, K. Suyama, M. P. Scott, J. D. Axelrod, and L. V. Goodrich Asymmetric Distribution of Prickle-Like 2 Reveals an Early Underlying Polarization of Vestibular Sensory Epithelia in the Inner Ear J. Neurosci., March 21, 2007; 27(12): 3139 - 3147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang and J. Nathans Tissue/planar cell polarity in vertebrates: new insights and new questions Development, February 15, 2007; 134(4): 647 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, T. Badea, and J. Nathans Order from disorder: Self-organization in mammalian hair patterning PNAS, December 26, 2006; 103(52): 19800 - 19805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Mirkovic and M. Mlodzik Cooperative activities of Drosophila DE-Cadherin and DN-Cadherin regulate the cell motility process of ommatidial rotation Development, September 1, 2006; 133(17): 3283 - 3293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, N. Guo, and J. Nathans The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J. Neurosci., February 22, 2006; 26(8): 2147 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Price, D. M. Roberts, B. M. McCartney, E. Jezuit, and M. Peifer Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle J. Cell Sci., February 1, 2006; 119(3): 403 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kondo, S. A. Johnson, M. C. Yoder, R. Romand, and E. Hashino From The Cover: Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells PNAS, March 29, 2005; 102(13): 4789 - 4794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Hawkins and M. Lovett The developmental genetics of auditory hair cells Hum. Mol. Genet., October 1, 2004; 13(suppl_2): R289 - R296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Barald and M. W. Kelley From placode to polarization: new tunes in inner ear development Development, September 1, 2004; 131(17): 4119 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matakatsu and S. S. Blair Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing Development, August 1, 2004; 131(15): 3785 - 3794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Klein and M. Mlodzik A conserved signaling cassette regulates hair patterning from Drosophila to man PNAS, June 22, 2004; 101(25): 9173 - 9174. [Full Text] [PDF]
|
|
|
|
|
|
N. Guo, C. Hawkins, and J. Nathans From The Cover: Frizzled6 controls hair patterning in mice PNAS, June 22, 2004; 101(25): 9277 - 9281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Strutt Frizzled signalling and cell polarisation in Drosophila and vertebrates Development, October 1, 2003; 130(19): 4501 - 4513. [Abstract] [Full Text] [PDF]
|
|
