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doi: 10.1242/10.1242/dev.00497

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Development 130, 2567-2577 (2003)
Copyright © 2003 The Company of Biologists Limited

The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development

Gopal Battu, Erika Froehli Hoier and Alex Hajnal*

Zoologisches Institut, Universitaet Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland

* Author for correspondence (e-mail: ahajnal{at}zool.unizh.ch)

Accepted 18 March 2003

In C. elegans, the RAS/MAPK pathway is used in different tissues to regulate various cell fate decisions. Several positive and negative regulators tightly control the activity of the RAS/MAPK pathway at different steps. We demonstrate a link between a G-protein-coupled receptor signalling pathway and the RAS/MAPK cascade. SRA-13, a member of the SRA family of chemosensory receptors, negatively regulates RAS/MAPK signalling during vulval induction and the olfaction of volatile attractants. Epistasis analysis indicates that SRA-13 inhibits the RAS/MAPK pathway at the level or upstream of MAPK. In both tissues, the vulval precursor cells and the chemosensory neurones, SRA-13 acts through the GPA-5 G{alpha} protein subunit, suggesting a common mechanism of crosstalk. Moreover, we find that vulval induction is repressed by food withdrawal during larval development and that SRA-13 activity is required for the suppression of vulval induction in response to food starvation. Thus, SRA-13 may serve to adapt the activity of the RAS/MAPK pathway to environmental conditions.

Key words: RAS, MAPK, G protein, Caenorhabditis elegans




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© The Company of Biologists Ltd 2003