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doi: 10.1242/10.1242/dev.00466

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Development 130, 2603-2610 (2003)
Copyright © 2003 The Company of Biologists Limited

Development of the Drosophila mushroom bodies: elaboration, remodeling and spatial organization of dendrites in the calyx

Sijun Zhu1, Ann-Shyn Chiang2 and Tzumin Lee3,*

1 Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
2 Department of Life Science, National Tsing Hua University, Hsinchu, 30043, Taiwan
3 Department of Cell and Structural Biology, University of Illinois, Urbana, IL 61801, USA

* Author for correspondence (e-mail: tzumin{at}life.uiuc.edu)

Accepted 4 March 2003

One Drosophila mushroom body (MB) is derived from four indistinguishable cell lineages, development of which involves sequential generation of multiple distinct types of neurons. Differential labeling of distinct MB clones reveals that MB dendrites of different clonal origins are well mixed at the larval stage but become restricted to distinct spaces in adults. Interestingly, a small dendritic domain in the adult MB calyx remains as a fourfold structure that, similar to the entire larval calyx, receives dendritic inputs from all four MB clones. Mosaic analysis of single neurons demonstrates that MB neurons, which are born around pupal formation, acquire unique dendritic branching patterns and consistently project their primary dendrites into the fourfold dendritic domain. Distinct dendrite distribution patterns are also observed for other subtypes of MB neurons. In addition, pruning of larval dendrites during metamorphosis allows for establishment of adult-specific dendrite elaboration/distribution patterns. Taken together, subregional differences exist in the adult Drosophila MB calyx, where processing and integration of distinct types of sensory information begin.

Key words: Drosophila, Mushroom body, Dendritic elaboration, Mosaic analysis, Remodeling


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Development 2003 130: 1202. [Full Text]  



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© The Company of Biologists Ltd 2003